iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028444

Ensembl Protein ID

ENSDARP00000005309.7

UniProt Accession

Q90XF2; Q7ZU17; KPCI_DANRE

Genbank Protein ID

AAK91291.1; AAH47164.1

Protein Name

Protein kinase C iota type; Atypical protein kinase C-lambda/iota; Heart and soul protein; nPKC-iota

Genbank Nucleotide ID

AF390109; BC047164

Gene Name

prkci; hal

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000021225.8	ENSDART00000015723.7	ENSDARP00000005309.7

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	3.50e-21	76.1	18	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           +vrvk++y+g+i  + +++e+++++e L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 18   QVRVKAYYRGDI--MITHFEPSISYEGLCNEVRDMCSMDNdQLFTMKWIDEEGDPCTVSSQLELEEALRLYElNKDSELIIHVF 99
           69**********..88******************************************************************98 PP

Organism

Danio rerio

Functional Description
(View)

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division.

Protein Sequence
(Fasta)

MPTLRDSTMS HPGENPHQVR VKAYYRGDIM ITHFEPSISY EGLCNEVRDM CSMDNDQLFT 60
MKWIDEEGDP CTVSSQLELE EALRLYELNK DSELIIHVFP CVPEKPGMPC PGEDKSIYRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCTCCAC ATTCCGCTGT TTGGATCAGT CCGTCTCGAG GCCTGCGCGA CAGAAGAAGG 60
GAGTGTTTCC CCGTCTGACA GAACTTCTAG TAGTCCGATT AATTTCCGTC TGAACTTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0031226--C:intrinsic component of plasma membrane
GO:0005634--C:nucleus
GO:0005915--C:zonula adherens
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0034334--P:adherens junction maintenance
GO:0034332--P:adherens junction organization
GO:0007420--P:brain development
GO:0045217--P:cell-cell junction maintenance
GO:0045216--P:cell-cell junction organization
GO:0007502--P:digestive tract mesoderm development
GO:0048546--P:digestive tract morphogenesis
GO:0021744--P:dorsal motor nucleus of vagus nerve development
GO:0035050--P:embryonic heart tube development
GO:0000132--P:establishment of mitotic spindle orientation
GO:0016332--P:establishment or maintenance of polarity of embryonic epithelium
GO:0048699--P:generation of neurons
GO:0007507--P:heart development
GO:0035556--P:intracellular signal transduction
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0008078--P:mesodermal cell migration
GO:0001738--P:morphogenesis of a polarized epithelium
GO:0001841--P:neural tube formation
GO:0007405--P:neuroblast proliferation
GO:0007097--P:nuclear migration
GO:0042476--P:odontogenesis
GO:0018105--P:peptidyl-serine phosphorylation
GO:0035845--P:photoreceptor cell outer segment organization
GO:0035778--P:pronephric nephron tubule epithelial cell differentiation
GO:0060041--P:retina development in camera-type eye
GO:0060042--P:retina morphogenesis in camera-type eye
GO:0021591--P:ventricular system development

KEGG

dre:117507

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	89.31	0.00e+00	934.00
IUUC-Apl-003711	Anas platyrhynchos	90.07	0.00e+00	1023.00
IUUC-Aca-005142	Anolis carolinensis	89.70	0.00e+00	1035.00
IUUC-Ame-010977	Astyanax mexicanus	91.50	0.00e+00	1058.00
IUUC-Bta-013414	Bos taurus	88.59	0.00e+00	1060.00
IUUC-Cel-018340	Caenorhabditis elegans	58.26	0.00e+00	699.00
IUUC-Cja-019802	Callithrix jacchus	89.70	0.00e+00	1019.00
IUUC-Cfa-021236	Canis familiaris	87.92	0.00e+00	1044.00
IUUC-Cpo-022127	Cavia porcellus	87.48	0.00e+00	987.00
IUUC-Csa-023332	Chlorocebus sabaeus	89.42	0.00e+00	866.00
IUUC-Cho-025054	Choloepus hoffmanni	91.06	1.00e-64	241.00
IUUC-Cin-025740	Ciona intestinalis	58.85	0.00e+00	691.00
IUUC-Csv-026145	Ciona savignyi	61.01	0.00e+00	695.00
IUUC-Dno-029228	Dasypus novemcinctus	96.77	0.00e+00	632.00
IUUC-Dme-031630	Drosophila melanogaster	67.01	0.00e+00	798.00
IUUC-Ete-032633	Echinops telfairi	67.41	5.00e-174	604.00
IUUC-Eca-033572	Equus caballus	89.68	0.00e+00	1021.00
IUUC-Eeu-035110	Erinaceus europaeus	88.74	0.00e+00	1052.00
IUUC-Fca-035559	Felis catus	88.26	0.00e+00	1059.00
IUUC-Fal-036953	Ficedula albicollis	90.21	0.00e+00	1021.00
IUUC-Gmo-039334	Gadus morhua	92.18	0.00e+00	1096.00
IUUC-Gga-040223	Gallus gallus	87.98	0.00e+00	1053.00
IUUC-Gac-042113	Gasterosteus aculeatus	91.23	0.00e+00	1089.00
IUUC-Ggo-044520	Gorilla gorilla	84.31	0.00e+00	957.00
IUUC-Hsa-046991	Homo sapiens	88.42	0.00e+00	1061.00
IUUC-Lch-050263	Latimeria chalumnae	87.46	0.00e+00	1040.00
IUUC-Loc-052221	Lepisosteus oculatus	91.85	0.00e+00	1052.00
IUUC-Laf-053591	Loxodonta africana	88.59	0.00e+00	1059.00
IUUC-Mcc-055118	Macaca mulatta	88.24	0.00e+00	1047.00
IUUC-Mga-059886	Meleagris gallopavo	90.07	0.00e+00	1021.00
IUUC-Mmr-060926	Microcebus murinus	88.59	0.00e+00	1061.00
IUUC-Mdo-062698	Monodelphis domestica	85.26	0.00e+00	1015.00
IUUC-Mmu-063689	Mus musculus	88.09	0.00e+00	1049.00
IUUC-Mpu-066630	Mustela putorius furo	89.43	0.00e+00	1046.00
IUUC-Mlu-067416	Myotis lucifugus	86.10	0.00e+00	1007.00
IUUC-Nle-069811	Nomascus leucogenys	88.42	0.00e+00	1059.00
IUUC-Opr-070466	Ochotona princeps	79.60	0.00e+00	679.00
IUUC-Ont-072278	Oreochromis niloticus	88.93	0.00e+00	1008.00
IUUC-Oan-073651	Ornithorhynchus anatinus	96.13	0.00e+00	726.00
IUUC-Ocu-074383	Oryctolagus cuniculus	88.42	0.00e+00	1060.00
IUUC-Ola-087283	Oryzias latipes	84.50	0.00e+00	836.00
IUUC-Oga-088337	Otolemur garnettii	81.20	0.00e+00	951.00
IUUC-Oar-089954	Ovis aries	89.88	0.00e+00	1028.00
IUUC-Ptr-091673	Pan troglodytes	88.42	0.00e+00	1061.00
IUUC-Pan-092494	Papio anubis	88.42	0.00e+00	1057.00
IUUC-Psi-094044	Pelodiscus sinensis	86.49	0.00e+00	1041.00
IUUC-Pfo-096661	Poecilia formosa	88.94	0.00e+00	1040.00
IUUC-Pab-097659	Pongo abelii	88.09	0.00e+00	1053.00
IUUC-Pca-101107	Procavia capensis	89.53	0.00e+00	726.00
IUUC-Rno-105790	Rattus norvegicus	88.26	0.00e+00	1055.00
IUUC-Sha-106895	Sarcophilus harrisii	89.58	0.00e+00	1004.00
IUUC-Sar-113513	Sorex araneus	85.05	4.00e-153	535.00
IUUC-Ssc-115835	Sus scrofa	89.08	0.00e+00	936.00
IUUC-Tgu-116874	Taeniopygia guttata	87.85	0.00e+00	1048.00
IUUC-Tru-117823	Takifugu rubripes	91.00	0.00e+00	1048.00
IUUC-Tsy-119154	Tarsius syrichta	89.88	0.00e+00	1020.00
IUUC-Tni-119968	Tetraodon nigroviridis	90.64	0.00e+00	1044.00
IUUC-Tbe-127238	Tupaia belangeri	71.05	0.00e+00	669.00
IUUC-Ttr-129208	Tursiops truncatus	88.27	0.00e+00	1059.00
IUUC-Vpa-130363	Vicugna pacos	79.70	0.00e+00	920.00
IUUC-Xtr-132652	Xenopus tropicalis	83.90	0.00e+00	1002.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence