iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	DrugBank	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	16949360

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/PB1	3.00e-21	77.1	25	106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           +vrvk++y+g+i  + +++e++++fe L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 25   QVRVKAYYRGDI--MITHFEPSISFEGLCNEVRDMCSFDNeQLFTMKWIDEEGDPCTVSSQLELEEAFRLYElNKDSELLIHVF 106
           69**********..88******************************************************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.

Protein Sequence
(Fasta)

MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF 60
DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGCGCCC GCCCTACCCC GGAATGTGGG CCTTTGGAGC GAGCGAAGTG GGAGGGACCG 60
ACGCAGGAGG TGTCTTGGGC CCGGGCGGCT GTAGAGGCGG CGGCGCCTAC GGGCAGTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0418--Kinase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005923--C:bicellular tight junction
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004672--F:protein kinase activity
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007015--P:actin filament organization
GO:0070830--P:bicellular tight junction assembly
GO:0016477--P:cell migration
GO:0045216--P:cell-cell junction organization
GO:0032869--P:cellular response to insulin stimulus
GO:0007010--P:cytoskeleton organization
GO:0035089--P:establishment of apical/basal cell polarity
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0042462--P:eye photoreceptor cell development
GO:0048194--P:Golgi vesicle budding
GO:0035556--P:intracellular signal transduction
GO:0061024--P:membrane organization
GO:0043066--P:negative regulation of apoptotic process
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:2000353--P:positive regulation of endothelial cell apoptotic process
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252--P:positive regulation of glial cell proliferation
GO:0046326--P:positive regulation of glucose import
GO:0010976--P:positive regulation of neuron projection development
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006468--P:protein phosphorylation
GO:0006612--P:protein targeting to membrane
GO:0070555--P:response to interleukin-1
GO:0046903--P:secretion
GO:0016192--P:vesicle-mediated transport

KEGG

hsa:5584

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	99.05	0.00e+00	1047.00
IUUC-Apl-003711	Anas platyrhynchos	95.74	0.00e+00	1095.00
IUUC-Aca-005142	Anolis carolinensis	94.95	0.00e+00	1109.00
IUUC-Ame-010977	Astyanax mexicanus	87.42	0.00e+00	1012.00
IUUC-Bta-013414	Bos taurus	99.16	0.00e+00	1207.00
IUUC-Bol-015169	Brassica oleracea	35.29	6.00e-51	196.00
IUUC-Cel-018340	Caenorhabditis elegans	58.43	0.00e+00	705.00
IUUC-Cja-019802	Callithrix jacchus	99.47	0.00e+00	1137.00
IUUC-Cfa-021236	Canis familiaris	98.49	0.00e+00	1166.00
IUUC-Cpo-022127	Cavia porcellus	97.35	0.00e+00	1087.00
IUUC-Csa-023332	Chlorocebus sabaeus	99.79	0.00e+00	976.00
IUUC-Cho-025054	Choloepus hoffmanni	67.66	3.00e-131	462.00
IUUC-Cin-025740	Ciona intestinalis	59.50	0.00e+00	704.00
IUUC-Csv-026145	Ciona savignyi	60.80	0.00e+00	706.00
IUUC-Dre-028444	Danio rerio	88.42	0.00e+00	1035.00
IUUC-Dno-029228	Dasypus novemcinctus	100.00	0.00e+00	649.00
IUUC-Dme-031630	Drosophila melanogaster	66.45	0.00e+00	802.00
IUUC-Ete-032633	Echinops telfairi	73.52	0.00e+00	653.00
IUUC-Eca-033572	Equus caballus	99.47	0.00e+00	1140.00
IUUC-Eeu-035110	Erinaceus europaeus	98.13	0.00e+00	1174.00
IUUC-Fca-035559	Felis catus	98.83	0.00e+00	1206.00
IUUC-Fal-036953	Ficedula albicollis	96.44	0.00e+00	1104.00
IUUC-Gmo-039334	Gadus morhua	87.92	0.00e+00	1053.00
IUUC-Gga-040223	Gallus gallus	93.82	0.00e+00	1132.00
IUUC-Gac-042113	Gasterosteus aculeatus	88.42	0.00e+00	1061.00
IUUC-Ggo-044520	Gorilla gorilla	93.21	0.00e+00	1083.00
IUUC-Lch-050263	Latimeria chalumnae	88.76	0.00e+00	1075.00
IUUC-Loc-052221	Lepisosteus oculatus	89.43	0.00e+00	1046.00
IUUC-Laf-053591	Loxodonta africana	98.83	0.00e+00	1205.00
IUUC-Mcc-055118	Macaca mulatta	96.98	0.00e+00	1166.00
IUUC-Mga-059886	Meleagris gallopavo	95.57	0.00e+00	1093.00
IUUC-Mmr-060926	Microcebus murinus	99.66	0.00e+00	1214.00
IUUC-Mdo-062698	Monodelphis domestica	93.54	0.00e+00	1131.00
IUUC-Mmu-063689	Mus musculus	98.32	0.00e+00	1191.00
IUUC-Mpu-066630	Mustela putorius furo	99.14	0.00e+00	1179.00
IUUC-Mlu-067416	Myotis lucifugus	95.31	0.00e+00	1118.00
IUUC-Nle-069811	Nomascus leucogenys	99.50	0.00e+00	1211.00
IUUC-Opr-070466	Ochotona princeps	86.55	0.00e+00	750.00
IUUC-Ont-072278	Oreochromis niloticus	86.70	0.00e+00	992.00
IUUC-Oan-073651	Ornithorhynchus anatinus	98.62	0.00e+00	746.00
IUUC-Ocu-074383	Oryctolagus cuniculus	99.16	0.00e+00	1208.00
IUUC-Ola-087283	Oryzias latipes	82.00	0.00e+00	806.00
IUUC-Oga-088337	Otolemur garnettii	90.52	0.00e+00	1073.00
IUUC-Oar-089954	Ovis aries	99.64	0.00e+00	1147.00
IUUC-Ptr-091673	Pan troglodytes	100.00	0.00e+00	1217.00
IUUC-Pan-092494	Papio anubis	99.83	0.00e+00	1212.00
IUUC-Psi-094044	Pelodiscus sinensis	93.57	0.00e+00	1129.00
IUUC-Pfo-096661	Poecilia formosa	86.88	0.00e+00	1016.00
IUUC-Pab-097659	Pongo abelii	99.33	0.00e+00	1209.00
IUUC-Pca-101107	Procavia capensis	98.50	0.00e+00	809.00
IUUC-Rno-105790	Rattus norvegicus	98.66	0.00e+00	1198.00
IUUC-Sha-106895	Sarcophilus harrisii	97.17	0.00e+00	1100.00
IUUC-Sar-113513	Sorex araneus	99.07	0.00e+00	635.00
IUUC-Ssc-115835	Sus scrofa	99.04	0.00e+00	1050.00
IUUC-Tgu-116874	Taeniopygia guttata	93.68	0.00e+00	1134.00
IUUC-Tru-117823	Takifugu rubripes	88.21	0.00e+00	1025.00
IUUC-Tsy-119154	Tarsius syrichta	99.11	0.00e+00	1135.00
IUUC-Tni-119968	Tetraodon nigroviridis	85.55	0.00e+00	1008.00
IUUC-Tbe-127238	Tupaia belangeri	79.60	0.00e+00	758.00
IUUC-Ttr-129208	Tursiops truncatus	98.99	0.00e+00	1203.00
IUUC-Vpa-130363	Vicugna pacos	88.63	0.00e+00	1037.00
IUUC-Xtr-132652	Xenopus tropicalis	87.60	0.00e+00	1062.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence