iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053591

Ensembl Protein ID

ENSLAFP00000004124.4

UniProt Accession

G3SV72; G3SV72_LOXAF

Protein Name

Protein kinase C

Gene Name

PRKCI

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000004925.4	ENSLAFT00000004926.4	ENSLAFP00000004124.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	9.70e-22	77.3	25	106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           +vrvk++y+g+i  + +++e++++fe L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 25   QVRVKAYYRGDI--MITHFEPSISFEGLCSEVRDMCSFDNeQLFTMKWIDEEGDPCTVSSQLELEEAFRLYElNKDSELLIHVF 106
           69**********..88******************************************************************98 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MPTQRDSSTM SHRVAAGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CSEVRDMCSF 60
DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGACCC AGAGGGACAG CAGCACCATG TCCCACCGGG TCGCAGCGGC GGCGGCAGCG 60
GGGACCATTC TCACCAGGTC CGGGTGAAAG CCTACTACCG CGGGTGAGTG ACGTGGGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004697--F:protein kinase C activity
GO:0007015--P:actin filament organization
GO:0045216--P:cell-cell junction organization
GO:0032869--P:cellular response to insulin stimulus
GO:0035089--P:establishment of apical/basal cell polarity
GO:0042462--P:eye photoreceptor cell development
GO:0035556--P:intracellular signal transduction
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:2000353--P:positive regulation of endothelial cell apoptotic process
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252--P:positive regulation of glial cell proliferation
GO:0046326--P:positive regulation of glucose import
GO:0010976--P:positive regulation of neuron projection development
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	99.05	0.00e+00	1028.00
IUUC-Apl-003711	Anas platyrhynchos	96.10	0.00e+00	1076.00
IUUC-Aca-005142	Anolis carolinensis	95.12	0.00e+00	1088.00
IUUC-Ame-010977	Astyanax mexicanus	87.92	0.00e+00	995.00
IUUC-Bta-013414	Bos taurus	98.83	0.00e+00	1182.00
IUUC-Bol-015169	Brassica oleracea	35.29	5.00e-51	196.00
IUUC-Cel-018340	Caenorhabditis elegans	58.53	0.00e+00	692.00
IUUC-Cja-019802	Callithrix jacchus	99.29	0.00e+00	1114.00
IUUC-Cfa-021236	Canis familiaris	98.15	0.00e+00	1137.00
IUUC-Cpo-022127	Cavia porcellus	97.18	0.00e+00	1063.00
IUUC-Csa-023332	Chlorocebus sabaeus	99.38	0.00e+00	954.00
IUUC-Cho-025054	Choloepus hoffmanni	66.92	2.00e-129	456.00
IUUC-Cin-025740	Ciona intestinalis	60.13	0.00e+00	695.00
IUUC-Csv-026145	Ciona savignyi	60.98	0.00e+00	697.00
IUUC-Dre-028444	Danio rerio	88.59	0.00e+00	1012.00
IUUC-Dno-029228	Dasypus novemcinctus	99.68	0.00e+00	648.00
IUUC-Dme-031630	Drosophila melanogaster	66.61	0.00e+00	790.00
IUUC-Ete-032633	Echinops telfairi	73.52	0.00e+00	629.00
IUUC-Eca-033572	Equus caballus	99.64	0.00e+00	1121.00
IUUC-Eeu-035110	Erinaceus europaeus	98.45	0.00e+00	1152.00
IUUC-Fca-035559	Felis catus	98.83	0.00e+00	1186.00
IUUC-Fal-036953	Ficedula albicollis	96.98	0.00e+00	1087.00
IUUC-Gmo-039334	Gadus morhua	87.92	0.00e+00	1028.00
IUUC-Gga-040223	Gallus gallus	94.16	0.00e+00	1113.00
IUUC-Gac-042113	Gasterosteus aculeatus	88.59	0.00e+00	1036.00
IUUC-Ggo-044520	Gorilla gorilla	92.02	0.00e+00	1058.00
IUUC-Hsa-046991	Homo sapiens	98.83	0.00e+00	1183.00
IUUC-Lch-050263	Latimeria chalumnae	88.76	0.00e+00	1052.00
IUUC-Loc-052221	Lepisosteus oculatus	89.60	0.00e+00	1025.00
IUUC-Mcc-055118	Macaca mulatta	95.97	0.00e+00	1138.00
IUUC-Mga-059886	Meleagris gallopavo	96.10	0.00e+00	1076.00
IUUC-Mmr-060926	Microcebus murinus	98.99	0.00e+00	1186.00
IUUC-Mdo-062698	Monodelphis domestica	93.87	0.00e+00	1113.00
IUUC-Mmu-063689	Mus musculus	98.32	0.00e+00	1172.00
IUUC-Mpu-066630	Mustela putorius furo	99.14	0.00e+00	1159.00
IUUC-Mlu-067416	Myotis lucifugus	94.97	0.00e+00	1090.00
IUUC-Nle-069811	Nomascus leucogenys	98.83	0.00e+00	1182.00
IUUC-Opr-070466	Ochotona princeps	86.32	0.00e+00	738.00
IUUC-Ont-072278	Oreochromis niloticus	87.22	0.00e+00	973.00
IUUC-Oan-073651	Ornithorhynchus anatinus	98.90	0.00e+00	746.00
IUUC-Ocu-074383	Oryctolagus cuniculus	98.99	0.00e+00	1185.00
IUUC-Ola-087283	Oryzias latipes	81.82	0.00e+00	803.00
IUUC-Oga-088337	Otolemur garnettii	90.18	0.00e+00	1049.00
IUUC-Oar-089954	Ovis aries	99.29	0.00e+00	1124.00
IUUC-Ptr-091673	Pan troglodytes	98.83	0.00e+00	1183.00
IUUC-Pan-092494	Papio anubis	98.99	0.00e+00	1184.00
IUUC-Psi-094044	Pelodiscus sinensis	93.25	0.00e+00	1108.00
IUUC-Pfo-096661	Poecilia formosa	86.71	0.00e+00	993.00
IUUC-Pab-097659	Pongo abelii	98.83	0.00e+00	1182.00
IUUC-Pca-101107	Procavia capensis	98.50	0.00e+00	787.00
IUUC-Rno-105790	Rattus norvegicus	98.66	0.00e+00	1179.00
IUUC-Sha-106895	Sarcophilus harrisii	97.35	0.00e+00	1079.00
IUUC-Sar-113513	Sorex araneus	99.07	0.00e+00	638.00
IUUC-Ssc-115835	Sus scrofa	99.04	0.00e+00	1030.00
IUUC-Tgu-116874	Taeniopygia guttata	94.18	0.00e+00	1115.00
IUUC-Tru-117823	Takifugu rubripes	88.38	0.00e+00	1001.00
IUUC-Tsy-119154	Tarsius syrichta	99.29	0.00e+00	1118.00
IUUC-Tni-119968	Tetraodon nigroviridis	85.88	0.00e+00	987.00
IUUC-Tbe-127238	Tupaia belangeri	79.39	0.00e+00	758.00
IUUC-Ttr-129208	Tursiops truncatus	98.66	0.00e+00	1179.00
IUUC-Vpa-130363	Vicugna pacos	88.63	0.00e+00	1015.00
IUUC-Xtr-132652	Xenopus tropicalis	86.93	0.00e+00	1037.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence