iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
iRefIndex	Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	22033112

Organism

Homo sapiens

Functional Description
(View)

Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.

Protein Sequence
(Fasta)

MGKARRSPPG HHRHCEGCFN RHCHIPVEPN TSCLVISCHL LCGATFHMCK EAEHQLLCPL 60
EQVPCLNSEY GCPLSMSRHK LAKHLQVCPA SVVCCSMEWN RWPNVDSETT LHENIMKETP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTTCTGGC CTTGAAAATG ATCCTTCTTA AAAGGATTTT CCTCCTTCCT CAAGGGAAAG 60
AAAACCTATT GATATAAAAC TTCACTTCCC ATTCAGTTTC CCCTGCTAAA TGCCACTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR031890--Fbxo30/Fbxo40
IPR008974--TRAF-like
IPR013083--Znf_RING/FYVE/PHD
IPR001293--Znf_TRAF

PROSITE

PS50181--FBOX
PS50145--ZF_TRAF

Pfam

PF15966--F-box_4
PF15965--zf-TRAF_2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042692--P:muscle cell differentiation
GO:0000209--P:protein polyubiquitination

KEGG

hsa:51725

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001882	Ailuropoda melanoleuca	89.70	0.00e+00	1214.00
IUUC-Apl-003788	Anas platyrhynchos	65.96	0.00e+00	907.00
IUUC-Aca-004624	Anolis carolinensis	61.40	0.00e+00	871.00
IUUC-Afl-008411	Aspergillus flavus	25.21	7.90e-02	30.00
IUUC-Ame-011599	Astyanax mexicanus	50.42	0.00e+00	706.00
IUUC-Bta-013376	Bos taurus	87.38	0.00e+00	1214.00
IUUC-Cja-019840	Callithrix jacchus	95.06	0.00e+00	1291.00
IUUC-Cfa-020146	Canis familiaris	86.78	0.00e+00	1205.00
IUUC-Cpo-021483	Cavia porcellus	85.45	0.00e+00	1225.00
IUUC-Csa-023141	Chlorocebus sabaeus	97.88	0.00e+00	1316.00
IUUC-Cho-024945	Choloepus hoffmanni	86.44	0.00e+00	1263.00
IUUC-Dre-027812	Danio rerio	45.30	2.00e-172	599.00
IUUC-Dno-030088	Dasypus novemcinctus	88.19	0.00e+00	1235.00
IUUC-Dor-030549	Dipodomys ordii	87.18	0.00e+00	1264.00
IUUC-Eca-034434	Equus caballus	90.01	0.00e+00	1258.00
IUUC-Eeu-035064	Erinaceus europaeus	86.16	0.00e+00	1244.00
IUUC-Fca-035523	Felis catus	85.37	0.00e+00	1182.00
IUUC-Fal-037137	Ficedula albicollis	64.44	0.00e+00	879.00
IUUC-Gmo-039031	Gadus morhua	46.79	0.00e+00	639.00
IUUC-Gga-040532	Gallus gallus	66.72	0.00e+00	772.00
IUUC-Gac-041371	Gasterosteus aculeatus	47.19	0.00e+00	646.00
IUUC-Gma-042970	Glycine max	25.31	1.00e-02	35.80
IUUC-Ggo-044453	Gorilla gorilla	99.29	0.00e+00	1373.00
IUUC-Itr-048530	Ictidomys tridecemlineatus	87.91	0.00e+00	1245.00
IUUC-Kpa-049103	Komagataella pastoris	32.20	8.20e-02	32.30
IUUC-Lch-049573	Latimeria chalumnae	57.00	0.00e+00	816.00
IUUC-Loc-052475	Lepisosteus oculatus	53.55	0.00e+00	759.00
IUUC-Laf-054424	Loxodonta africana	87.06	0.00e+00	1275.00
IUUC-Mcc-055243	Macaca mulatta	97.74	0.00e+00	1318.00
IUUC-Meu-055909	Macropus eugenii	77.20	0.00e+00	1122.00
IUUC-Mga-060045	Meleagris gallopavo	65.53	0.00e+00	935.00
IUUC-Mmr-061531	Microcebus murinus	84.81	0.00e+00	1143.00
IUUC-Mdo-062838	Monodelphis domestica	78.95	0.00e+00	1122.00
IUUC-Mmu-064229	Mus musculus	84.91	0.00e+00	1236.00
IUUC-Mpu-066012	Mustela putorius furo	89.82	0.00e+00	1190.00
IUUC-Mlu-067170	Myotis lucifugus	88.54	0.00e+00	1239.00
IUUC-Nle-069819	Nomascus leucogenys	98.17	0.00e+00	1365.00
IUUC-Ont-072664	Oreochromis niloticus	49.22	0.00e+00	667.00
IUUC-Oan-072948	Ornithorhynchus anatinus	58.88	0.00e+00	776.00
IUUC-Ocu-074610	Oryctolagus cuniculus	88.01	0.00e+00	1288.00
IUUC-Ola-087480	Oryzias latipes	47.94	0.00e+00	629.00
IUUC-Oga-088445	Otolemur garnettii	88.42	0.00e+00	1264.00
IUUC-Oar-089876	Ovis aries	86.97	0.00e+00	1201.00
IUUC-Ptr-090727	Pan troglodytes	99.44	0.00e+00	1377.00
IUUC-Pan-092488	Papio anubis	97.88	0.00e+00	1318.00
IUUC-Psi-093321	Pelodiscus sinensis	64.13	0.00e+00	820.00
IUUC-Pno-095023	Phaeosphaeria nodorum	31.88	1.00e-03	38.10
IUUC-Pfo-097321	Poecilia formosa	49.57	0.00e+00	671.00
IUUC-Pab-097637	Pongo abelii	98.59	0.00e+00	1364.00
IUUC-Pca-100632	Procavia capensis	88.21	0.00e+00	903.00
IUUC-Pva-102503	Pteropus vampyrus	88.31	0.00e+00	1263.00
IUUC-Ptt-103857	Puccinia triticina	31.91	6.60e-02	32.30
IUUC-Rno-105321	Rattus norvegicus	85.19	0.00e+00	1199.00
IUUC-Sha-106906	Sarcophilus harrisii	78.03	0.00e+00	1087.00
IUUC-Sar-113603	Sorex araneus	86.32	0.00e+00	1239.00
IUUC-Ssc-116153	Sus scrofa	81.33	0.00e+00	1117.00
IUUC-Tgu-117476	Taeniopygia guttata	64.31	0.00e+00	886.00
IUUC-Tru-118371	Takifugu rubripes	46.02	1.00e-173	603.00
IUUC-Tsy-118977	Tarsius syrichta	71.26	2.00e-139	489.00
IUUC-Tni-119795	Tetraodon nigroviridis	46.61	3.00e-178	619.00
IUUC-Tae-124508	Triticum aestivum	23.13	1.70e-01	31.20
IUUC-Tbe-127246	Tupaia belangeri	89.31	0.00e+00	1283.00
IUUC-Ttr-128674	Tursiops truncatus	85.63	0.00e+00	1131.00
IUUC-Vpa-130395	Vicugna pacos	83.80	0.00e+00	1147.00
IUUC-Xtr-132899	Xenopus tropicalis	57.76	0.00e+00	829.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence