iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.90e-24	85.3	105	141
UBD/Beta-Prp	6.60e-40	138.8	16	307

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           gH+ +v +l+    d++++sGs D+ti++WDlr+ ++
   Q: 105  GHSKRVVALSMspVDDTFISGSLDKTIRLWDLRSPNC 141
           799999999999755899**************99876 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgse..Drtikvwdlstgkcvhtlkghe 94
           ++ ++++ i+c +fsp+++ ++++s+d++i ++d ++gk  r+l++++ +v  +++ + +++ v +s+  D+ti+  +l ++k+++ + gh+
   Q: 16   VFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRYLSLHDNKYIRYFPGHS 107
           56678899*****************************************************9999998668********************* PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl....ktgkllrtltgghtds 182
           ++v++ls+sp +d+++sGs d+tir+wdl++  c       h +   + +++p+g ++++G + ++v+l+dl    k  +   +++ + t  
   Q: 108  KRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQG---LMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLrsfdKGPFATFKMQYDRTCE 196
           ***********************************8...4455555677899*9******************66554455555558888899 PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght...dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisva 271
            + l+f+ +gk ++   + + ++l d  +g +++t+ g+    + ++   f+p++++++ gs+Dg i +W+ +sg  + +l +++    +++
   Q: 197  WTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYAnskAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKH--TGPIT 286
           99999******************************99977333556677899*******************************66..88999 PP
   S: 272  vlsfgdnvlvlgsedskvniw 292
           +l+f+ + +  +s+ s+  +w
   Q: 287  CLQFNPKFMTFASACSNMAFW 307
           999998888888877666665 PP

Organism

Homo sapiens

Functional Description
(View)

Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Protein Sequence
(Fasta)

MKLTDSVLRS FRVAKVFREN SDKINCFDFS PNGETVISSS DDDSIVLYDC QEGKPKRTLY 60
SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI RYFPGHSKRV VALSMSPVDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGTAGGGC CTTAGCGAGG GAAATGGCTG CCGCGTAATG CCCGGTGATG CGAGAAAGAA 60
GGGCCTGCTG CCACCAGGAC CCGTCATCGC CCAGCCCAGG GACCGCTTCT GAAGGCCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000785--C:chromatin
GO:0035097--C:histone methyltransferase complex
GO:0005730--C:nucleolus
GO:0072357--C:PTW/PP1 phosphatase complex
GO:0048188--C:Set1C/COMPASS complex
GO:0003682--F:chromatin binding
GO:0051568--P:histone H3-K4 methylation
GO:0080182--P:histone H3-K4 trimethylation

KEGG

hsa:80335

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000390	Aegilops tauschii	39.62	1.00e-62	233.00
IUUC-Aml-001221	Ailuropoda melanoleuca	100.00	0.00e+00	636.00
IUUC-Atr-002607	Amborella trichopoda	40.38	1.00e-70	259.00
IUUC-Apl-003817	Anas platyrhynchos	97.70	3.00e-175	608.00
IUUC-Aca-005383	Anolis carolinensis	94.89	7.00e-176	609.00
IUUC-Aly-005437	Arabidopsis lyrata	39.42	8.00e-69	253.00
IUUC-Ath-006793	Arabidopsis thaliana	39.42	2.00e-68	253.00
IUUC-Ago-007804	Ashbya gossypii	33.97	2.00e-49	189.00
IUUC-Acl-008217	Aspergillus clavatus	36.66	6.00e-55	207.00
IUUC-Afl-008539	Aspergillus flavus	35.67	5.00e-56	211.00
IUUC-Afu-009105	Aspergillus fumigatus	36.66	5.00e-56	211.00
IUUC-Ani-009474	Aspergillus nidulans	35.93	4.00e-53	201.00
IUUC-Ang-009858	Aspergillus niger	37.13	3.00e-57	215.00
IUUC-Aor-009955	Aspergillus oryzae	35.67	5.00e-56	211.00
IUUC-Ate-010364	Aspergillus terreus	36.95	3.00e-57	215.00
IUUC-Ame-010661	Astyanax mexicanus	92.43	7.00e-169	587.00
IUUC-Bgr-012008	Blumeria graminis	35.84	8.00e-57	214.00
IUUC-Bta-013022	Bos taurus	100.00	5.00e-178	617.00
IUUC-Bci-013966	Botrytis cinerea	35.58	8.00e-51	194.00
IUUC-Bdi-015066	Brachypodium distachyon	41.48	1.00e-72	266.00
IUUC-Bol-016019	Brassica oleracea	40.06	3.00e-69	255.00
IUUC-Bra-017871	Brassica rapa	40.06	4.00e-69	254.00
IUUC-Cel-018276	Caenorhabditis elegans	43.09	3.00e-73	268.00
IUUC-Cja-019309	Callithrix jacchus	100.00	0.00e+00	636.00
IUUC-Cfa-020345	Canis familiaris	100.00	0.00e+00	636.00
IUUC-Cpo-022227	Cavia porcellus	92.38	1.00e-164	572.00
IUUC-Csa-023267	Chlorocebus sabaeus	94.25	5.00e-178	616.00
IUUC-Cho-024409	Choloepus hoffmanni	89.83	4.00e-146	510.00
IUUC-Cin-025628	Ciona intestinalis	70.16	5.00e-138	483.00
IUUC-Csv-026164	Ciona savignyi	70.06	8.00e-138	483.00
IUUC-Cgl-026516	Colletotrichum gloeosporioides	35.13	6.00e-52	197.00
IUUC-Cne-026890	Cryptococcus neoformans	28.39	3.00e-35	142.00
IUUC-Cme-027288	Cyanidioschyzon merolae	37.91	3.00e-65	242.00
IUUC-Dre-028001	Danio rerio	93.61	8.00e-175	605.00
IUUC-Dno-029056	Dasypus novemcinctus	100.00	0.00e+00	636.00
IUUC-Dor-031078	Dipodomys ordii	100.00	3.00e-121	427.00
IUUC-Dse-031152	Dothistroma septosporum	36.93	9.00e-58	217.00
IUUC-Dme-032085	Drosophila melanogaster	69.01	8.00e-140	489.00
IUUC-Ete-033158	Echinops telfairi	96.17	2.00e-178	617.00
IUUC-Eca-033879	Equus caballus	99.60	1.00e-150	526.00
IUUC-Eeu-035229	Erinaceus europaeus	88.82	3.00e-153	533.00
IUUC-Fca-035896	Felis catus	100.00	0.00e+00	636.00
IUUC-Fal-036843	Ficedula albicollis	97.70	3.00e-175	608.00
IUUC-Fox-037858	Fusarium oxysporum	36.81	6.00e-57	214.00
IUUC-Fso-038386	Fusarium solani	35.57	2.00e-48	186.00
IUUC-Gmo-038506	Gadus morhua	92.13	2.00e-167	582.00
IUUC-Ggr-040090	Gaeumannomyces graminis	37.87	6.00e-57	214.00
IUUC-Gga-040192	Gallus gallus	97.76	1.00e-180	625.00
IUUC-Gac-042494	Gasterosteus aculeatus	90.52	9.00e-164	570.00
IUUC-Gma-042835	Glycine max	41.72	8.00e-70	257.00
IUUC-Ggo-045204	Gorilla gorilla	100.00	8.00e-179	620.00
IUUC-Hvu-047690	Hordeum vulgare	39.30	8.00e-62	230.00
IUUC-Itr-048338	Ictidomys tridecemlineatus	100.00	0.00e+00	636.00
IUUC-Kpa-049249	Komagataella pastoris	36.53	6.00e-57	214.00
IUUC-Lch-050431	Latimeria chalumnae	94.81	2.00e-173	602.00
IUUC-Lpe-050830	Leersia perrieri	41.48	4.00e-72	265.00
IUUC-Loc-052505	Lepisosteus oculatus	96.59	2.00e-41	160.00
IUUC-Lma-053026	Leptosphaeria maculans	35.82	3.00e-59	222.00
IUUC-Laf-054265	Loxodonta africana	78.43	3.00e-130	457.00
IUUC-Mcc-055583	Macaca mulatta	100.00	0.00e+00	636.00
IUUC-Meu-056113	Macropus eugenii	85.30	3.00e-149	521.00
IUUC-Mor-057267	Magnaporthe oryzae	35.07	2.00e-50	192.00
IUUC-Mpo-057502	Magnaporthe poae	37.57	1.00e-55	210.00
IUUC-Mtr-058607	Medicago truncatula	41.40	1.00e-69	256.00
IUUC-Mla-058815	Melampsora laricipopulina	39.11	6.00e-70	258.00
IUUC-Mga-059407	Meleagris gallopavo	97.31	3.00e-153	533.00
IUUC-Mvi-060411	Microbotryum violaceum	37.02	3.00e-63	236.00
IUUC-Mmr-061470	Microcebus murinus	100.00	0.00e+00	636.00
IUUC-Mdo-062860	Monodelphis domestica	97.76	4.00e-180	623.00
IUUC-Mmu-063105	Mus musculus	100.00	0.00e+00	636.00
IUUC-Mac-065314	Musa acuminata	41.03	4.00e-70	258.00
IUUC-Mpu-066472	Mustela putorius furo	100.00	1.00e-155	541.00
IUUC-Mlu-067073	Myotis lucifugus	100.00	2.00e-180	624.00
IUUC-Nfi-068284	Neosartorya fischeri	36.66	4.00e-56	211.00
IUUC-Ncr-068702	Neurospora crassa	34.20	8.00e-46	177.00
IUUC-Nle-069451	Nomascus leucogenys	100.00	0.00e+00	636.00
IUUC-Opr-071112	Ochotona princeps	100.00	1.00e-155	541.00
IUUC-Ont-071988	Oreochromis niloticus	91.78	1.00e-167	583.00
IUUC-Oan-072947	Ornithorhynchus anatinus	97.68	5.00e-153	533.00
IUUC-Ocu-074969	Oryctolagus cuniculus	100.00	0.00e+00	636.00
IUUC-Oba-075229	Oryza barthii	37.70	1.00e-56	214.00
IUUC-Obr-076456	Oryza brachyantha	41.80	1.00e-72	266.00
IUUC-Ogl-076973	Oryza glaberrima	41.80	7.00e-73	267.00
IUUC-Ogu-078068	Oryza glumaepatula	37.38	8.00e-57	214.00
IUUC-Oin-079656	Oryza indica	41.80	1.00e-72	266.00
IUUC-Olo-080893	Oryza longistaminata	36.33	1.00e-53	203.00
IUUC-Ome-081559	Oryza meridionalis	36.65	7.00e-34	136.00
IUUC-Oni-082990	Oryza nivara	37.38	2.00e-56	213.00
IUUC-Opu-083374	Oryza punctata	38.02	8.00e-57	213.00
IUUC-Oru-084354	Oryza rufipogon	37.38	2.00e-56	213.00
IUUC-Osa-086296	Oryza sativa	41.80	1.00e-72	266.00
IUUC-Ola-087095	Oryzias latipes	92.33	2.00e-173	601.00
IUUC-Olu-087603	Ostreococcus lucimarinus	36.39	1.00e-55	210.00
IUUC-Oga-088766	Otolemur garnettii	100.00	0.00e+00	636.00
IUUC-Oar-089565	Ovis aries	97.76	6.00e-179	619.00
IUUC-Ptr-091219	Pan troglodytes	92.33	2.00e-174	604.00
IUUC-Pan-091733	Papio anubis	100.00	0.00e+00	636.00
IUUC-Psi-092972	Pelodiscus sinensis	97.38	3.00e-174	605.00
IUUC-Pma-094332	Petromyzon marinus	86.58	5.00e-169	586.00
IUUC-Pno-094960	Phaeosphaeria nodorum	38.89	2.00e-61	229.00
IUUC-Ppa-095292	Physcomitrella patens	45.19	9.00e-82	296.00
IUUC-Pfo-096775	Poecilia formosa	91.45	6.00e-167	580.00
IUUC-Pab-097721	Pongo abelii	97.76	2.00e-176	610.00
IUUC-Pop-098907	Populus trichocarpa	41.35	5.00e-70	258.00
IUUC-Pca-100635	Procavia capensis	98.84	3.00e-151	527.00
IUUC-Ppe-101860	Prunus persica	41.35	6.00e-71	260.00
IUUC-Pva-102798	Pteropus vampyrus	99.36	0.00e+00	632.00
IUUC-Pgr-103395	Puccinia graminis	38.76	8.00e-71	260.00
IUUC-Ptt-103747	Puccinia triticina	37.39	4.00e-67	248.00
IUUC-Pte-104129	Pyrenophora teres	38.00	5.00e-56	213.00
IUUC-Pyt-104773	Pyrenophora triticirepentis	35.14	3.00e-58	219.00
IUUC-Rno-106127	Rattus norvegicus	97.13	2.00e-175	608.00
IUUC-Sce-106257	Saccharomyces cerevisiae	33.75	6.00e-45	174.00
IUUC-Sha-106573	Sarcophilus harrisii	86.82	4.00e-160	557.00
IUUC-Sja-107724	Schizosaccharomyces japonicus	35.98	4.00e-47	181.00
IUUC-Spo-108206	Schizosaccharomyces pombe	34.65	2.00e-50	192.00
IUUC-Smo-108979	Selaginella moellendorffii	44.55	3.00e-80	291.00
IUUC-Sit-109858	Setaria italica	41.67	4.00e-72	265.00
IUUC-Sly-111267	Solanum lycopersicum	42.31	3.00e-71	262.00
IUUC-Sar-113079	Sorex araneus	100.00	1.00e-155	541.00
IUUC-Sbi-114094	Sorghum bicolor	37.70	1.00e-59	223.00
IUUC-Sre-115157	Sporisorium reilianum	34.46	4.00e-54	205.00
IUUC-Ssc-116386	Sus scrofa	100.00	0.00e+00	636.00
IUUC-Tgu-116465	Taeniopygia guttata	93.89	6.00e-147	514.00
IUUC-Tru-117604	Takifugu rubripes	91.45	2.00e-167	582.00
IUUC-Tsy-119314	Tarsius syrichta	76.80	9.00e-108	382.00
IUUC-Tni-120237	Tetraodon nigroviridis	91.12	2.00e-165	575.00
IUUC-Tca-121853	Theobroma cacao	41.35	3.00e-70	258.00
IUUC-Tre-122205	Trichoderma reesei	35.34	6.00e-54	204.00
IUUC-Tvi-122471	Trichoderma virens	31.61	1.00e-40	160.00
IUUC-Tae-124944	Triticum aestivum	41.80	7.00e-74	270.00
IUUC-Tur-126512	Triticum urartu	42.55	2.00e-59	222.00
IUUC-Tme-126883	Tuber melanosporum	40.37	4.00e-61	228.00
IUUC-Tbe-127310	Tupaia belangeri	93.18	1.00e-70	259.00
IUUC-Ttr-128307	Tursiops truncatus	100.00	1.00e-155	541.00
IUUC-Uma-129579	Ustilago maydis	34.59	2.00e-53	202.00
IUUC-Vda-129826	Verticillium dahliae	34.97	1.00e-51	196.00
IUUC-Vpa-130091	Vicugna pacos	100.00	1.00e-155	541.00
IUUC-Vvi-131040	Vitis vinifera	41.67	9.00e-71	261.00
IUUC-Xtr-132660	Xenopus tropicalis	94.52	3.00e-172	598.00
IUUC-Xma-133496	Xiphophorus maculatus	91.69	1.00e-172	598.00
IUUC-Yli-134509	Yarrowia lipolytica	38.32	4.00e-62	231.00
IUUC-Zma-134685	Zea mays	41.48	4.00e-72	264.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence