iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164162.12	ENST00000507656.5	ENSP00000423995.1
ENSG00000164162.12	ENST00000512680.5	ENSP00000425459.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	21107322; 16763193

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	36.23	2.00e-23	103.00	IUUC-Sce-106448

Organism

Homo sapiens

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL ETYWQSDGSQ 60
PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN NFHNLQEIRQ LELVEPSGWI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCGCTGCT GCTGTCTCCG CCACCTAAGG CCTAACCAAA GGCTCTCGGA GAACGTCCCT 60
ACATTCTTTC CAACCTGGCA GATGGCAGCT AACGGCCAAA CCTCTCCGGG CTATTCACGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016901--APC10
IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like

PROSITE

PS51284--DOC

Pfam

PF03256--ANAPC10

SMART

SM01337--APC10

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

KEGG

hsa:10393

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000560	Aegilops tauschii	55.24	2.00e-28	118.00
IUUC-Aml-001522	Ailuropoda melanoleuca	100.00	2.00e-110	390.00
IUUC-Atr-002797	Amborella trichopoda	57.83	1.00e-53	202.00
IUUC-Apl-004185	Anas platyrhynchos	98.38	5.00e-109	386.00
IUUC-Aca-004900	Anolis carolinensis	97.30	5.00e-107	379.00
IUUC-Aly-005760	Arabidopsis lyrata	55.42	2.00e-49	188.00
IUUC-Ath-007516	Arabidopsis thaliana	55.42	3.00e-49	187.00
IUUC-Ago-007889	Ashbya gossypii	33.15	1.00e-24	107.00
IUUC-Acl-008130	Aspergillus clavatus	41.75	2.00e-20	93.60
IUUC-Afl-008640	Aspergillus flavus	42.72	6.00e-20	92.00
IUUC-Afu-009101	Aspergillus fumigatus	41.75	5.00e-20	92.40
IUUC-Ani-009484	Aspergillus nidulans	42.72	3.00e-20	93.20
IUUC-Ang-009847	Aspergillus niger	40.78	6.00e-19	89.00
IUUC-Aor-010077	Aspergillus oryzae	42.72	6.00e-20	92.00
IUUC-Ate-010544	Aspergillus terreus	41.75	4.00e-20	92.80
IUUC-Ame-011330	Astyanax mexicanus	91.16	2.00e-80	291.00
IUUC-Bgr-011978	Blumeria graminis	42.24	9.00e-37	146.00
IUUC-Bta-013351	Bos taurus	100.00	2.00e-110	390.00
IUUC-Bci-013611	Botrytis cinerea	44.87	2.00e-36	146.00
IUUC-Bdi-014443	Brachypodium distachyon	53.76	3.00e-50	191.00
IUUC-Bol-015534	Brassica oleracea	56.29	5.00e-54	203.00
IUUC-Bra-017298	Brassica rapa	56.89	3.00e-54	204.00
IUUC-Cel-018170	Caenorhabditis elegans	48.55	4.00e-40	157.00
IUUC-Cja-019877	Callithrix jacchus	100.00	2.00e-110	390.00
IUUC-Cfa-020698	Canis familiaris	100.00	2.00e-110	390.00
IUUC-Cpo-022007	Cavia porcellus	99.46	1.00e-109	388.00
IUUC-Cre-023013	Chlamydomonas reinhardtii	51.52	2.00e-48	184.00
IUUC-Csa-023980	Chlorocebus sabaeus	100.00	2.00e-110	390.00
IUUC-Cho-024703	Choloepus hoffmanni	100.00	1.00e-84	304.00
IUUC-Cin-025346	Ciona intestinalis	52.46	3.00e-57	214.00
IUUC-Csv-026225	Ciona savignyi	53.41	6.00e-53	199.00
IUUC-Cgl-026544	Colletotrichum gloeosporioides	42.66	4.00e-32	131.00
IUUC-Cne-027042	Cryptococcus neoformans	40.82	5.00e-34	137.00
IUUC-Cme-027223	Cyanidioschyzon merolae	49.09	2.00e-28	120.00
IUUC-Dre-027804	Danio rerio	90.81	2.00e-101	360.00
IUUC-Dno-029995	Dasypus novemcinctus	100.00	2.00e-110	390.00
IUUC-Dor-030429	Dipodomys ordii	99.46	2.00e-109	387.00
IUUC-Dse-031499	Dothistroma septosporum	37.50	4.00e-32	131.00
IUUC-Dme-031675	Drosophila melanogaster	57.69	2.00e-62	231.00
IUUC-Ete-032499	Echinops telfairi	99.37	7.00e-94	335.00
IUUC-Eca-034281	Equus caballus	100.00	2.00e-110	390.00
IUUC-Eeu-034913	Erinaceus europaeus	99.19	2.00e-71	260.00
IUUC-Fca-036364	Felis catus	100.00	2.00e-110	390.00
IUUC-Fal-037041	Ficedula albicollis	98.38	5.00e-109	386.00
IUUC-Fox-037777	Fusarium oxysporum	39.61	1.00e-32	134.00
IUUC-Fso-038311	Fusarium solani	41.18	6.00e-33	135.00
IUUC-Gmo-039318	Gadus morhua	87.93	2.00e-59	219.00
IUUC-Ggr-039935	Gaeumannomyces graminis	41.10	2.00e-29	123.00
IUUC-Gga-041006	Gallus gallus	97.84	6.00e-109	385.00
IUUC-Gac-042367	Gasterosteus aculeatus	89.78	2.00e-100	357.00
IUUC-Gma-043650	Glycine max	56.71	2.00e-53	201.00
IUUC-Ggo-045044	Gorilla gorilla	100.00	2.00e-110	390.00
IUUC-Hvu-047485	Hordeum vulgare	57.69	5.00e-11	58.90
IUUC-Itr-048324	Ictidomys tridecemlineatus	100.00	9.00e-63	231.00
IUUC-Kpa-049293	Komagataella pastoris	42.28	3.00e-31	128.00
IUUC-Lch-049462	Latimeria chalumnae	91.84	7.00e-81	292.00
IUUC-Lpe-050846	Leersia perrieri	55.42	5.00e-48	184.00
IUUC-Loc-052857	Lepisosteus oculatus	91.89	2.00e-102	364.00
IUUC-Lma-052974	Leptosphaeria maculans	43.43	7.00e-18	85.10
IUUC-Laf-053536	Loxodonta africana	100.00	2.00e-110	390.00
IUUC-Mcc-054806	Macaca mulatta	100.00	2.00e-110	390.00
IUUC-Meu-056282	Macropus eugenii	96.05	8.00e-41	159.00
IUUC-Mor-057080	Magnaporthe oryzae	41.96	1.00e-29	124.00
IUUC-Mpo-057503	Magnaporthe poae	40.49	6.00e-29	121.00
IUUC-Mtr-057837	Medicago truncatula	56.29	3.00e-53	201.00
IUUC-Mla-059010	Melampsora laricipopulina	49.28	2.00e-32	131.00
IUUC-Mga-059728	Meleagris gallopavo	98.38	5.00e-109	386.00
IUUC-Mvi-060224	Microbotryum violaceum	40.83	3.00e-39	154.00
IUUC-Mdo-062602	Monodelphis domestica	98.38	4.00e-109	386.00
IUUC-Mmu-063528	Mus musculus	99.46	6.00e-110	389.00
IUUC-Mac-065629	Musa acuminata	60.40	1.00e-49	189.00
IUUC-Mpu-066046	Mustela putorius furo	100.00	2.00e-110	390.00
IUUC-Mlu-068107	Myotis lucifugus	100.00	2.00e-110	390.00
IUUC-Nfi-068426	Neosartorya fischeri	41.75	7.00e-20	92.00
IUUC-Ncr-068810	Neurospora crassa	41.96	6.00e-30	125.00
IUUC-Nle-069550	Nomascus leucogenys	100.00	2.00e-110	390.00
IUUC-Opr-071205	Ochotona princeps	100.00	3.00e-92	330.00
IUUC-Ont-071625	Oreochromis niloticus	90.81	2.00e-101	361.00
IUUC-Oan-073396	Ornithorhynchus anatinus	97.84	1.00e-108	385.00
IUUC-Ocu-074136	Oryctolagus cuniculus	99.46	4.00e-110	389.00
IUUC-Oba-075504	Oryza barthii	55.42	4.00e-48	184.00
IUUC-Obr-076300	Oryza brachyantha	56.02	4.00e-50	190.00
IUUC-Ogl-077163	Oryza glaberrima	55.42	4.00e-48	184.00
IUUC-Ogu-078459	Oryza glumaepatula	55.42	4.00e-48	184.00
IUUC-Oin-079095	Oryza indica	48.94	4.00e-44	171.00
IUUC-Olo-080226	Oryza longistaminata	48.65	4.00e-43	171.00
IUUC-Ome-081690	Oryza meridionalis	55.42	4.00e-48	184.00
IUUC-Oni-082984	Oryza nivara	55.42	4.00e-48	184.00
IUUC-Opu-083753	Oryza punctata	56.02	1.00e-52	199.00
IUUC-Oru-084459	Oryza rufipogon	55.42	4.00e-48	184.00
IUUC-Osa-085969	Oryza sativa	55.42	4.00e-48	184.00
IUUC-Ola-087291	Oryzias latipes	89.25	1.00e-99	355.00
IUUC-Olu-087704	Ostreococcus lucimarinus	51.92	2.00e-44	172.00
IUUC-Oga-088086	Otolemur garnettii	100.00	2.00e-110	390.00
IUUC-Oar-089191	Ovis aries	100.00	2.00e-110	390.00
IUUC-Ptr-091583	Pan troglodytes	100.00	2.00e-110	390.00
IUUC-Pan-092440	Papio anubis	100.00	2.00e-110	390.00
IUUC-Psi-093158	Pelodiscus sinensis	98.38	4.00e-109	386.00
IUUC-Pma-094382	Petromyzon marinus	69.74	3.00e-31	125.00
IUUC-Pno-094776	Phaeosphaeria nodorum	42.86	6.00e-21	95.10
IUUC-Ppa-095243	Physcomitrella patens	54.20	9.00e-39	153.00
IUUC-Pfo-096853	Poecilia formosa	89.78	2.00e-100	357.00
IUUC-Pab-098464	Pongo abelii	87.03	2.00e-91	327.00
IUUC-Pop-099055	Populus trichocarpa	56.47	9.00e-52	196.00
IUUC-Pca-100402	Procavia capensis	99.32	3.00e-85	306.00
IUUC-Ppe-101826	Prunus persica	54.22	1.00e-48	185.00
IUUC-Pva-102272	Pteropus vampyrus	100.00	2.00e-110	390.00
IUUC-Pgr-103519	Puccinia graminis	40.51	1.00e-34	139.00
IUUC-Ptt-103904	Puccinia triticina	32.76	2.00e-14	72.00
IUUC-Pte-104017	Pyrenophora teres	44.44	7.00e-22	98.60
IUUC-Pyt-104453	Pyrenophora triticirepentis	43.43	2.00e-21	96.30
IUUC-Rno-105561	Rattus norvegicus	99.46	6.00e-110	389.00
IUUC-Sce-106448	Saccharomyces cerevisiae	36.23	1.00e-23	103.00
IUUC-Sha-106901	Sarcophilus harrisii	98.38	4.00e-109	386.00
IUUC-Sja-107924	Schizosaccharomyces japonicus	43.56	4.00e-39	153.00
IUUC-Spo-108082	Schizosaccharomyces pombe	44.90	4.00e-37	147.00
IUUC-Ssl-108422	Sclerotinia sclerotiorum	46.15	2.00e-36	146.00
IUUC-Smo-109182	Selaginella moellendorffii	60.34	4.00e-57	213.00
IUUC-Sit-110292	Setaria italica	58.39	1.00e-48	186.00
IUUC-Sly-111772	Solanum lycopersicum	53.45	4.00e-46	177.00
IUUC-Stu-112789	Solanum tuberosum	54.02	3.00e-46	177.00
IUUC-Sar-113731	Sorex araneus	69.73	4.00e-68	250.00
IUUC-Sbi-114468	Sorghum bicolor	53.76	7.00e-53	199.00
IUUC-Sre-115201	Sporisorium reilianum	39.88	4.00e-33	135.00
IUUC-Ssc-115318	Sus scrofa	100.00	2.00e-110	390.00
IUUC-Tgu-116782	Taeniopygia guttata	97.84	6.00e-109	385.00
IUUC-Tru-117918	Takifugu rubripes	90.32	1.00e-100	358.00
IUUC-Tni-120731	Tetraodon nigroviridis	90.32	1.00e-100	358.00
IUUC-Tca-121546	Theobroma cacao	55.42	3.00e-49	187.00
IUUC-Tre-122092	Trichoderma reesei	42.96	4.00e-32	130.00
IUUC-Tvi-122416	Trichoderma virens	42.66	4.00e-32	132.00
IUUC-Tae-123195	Triticum aestivum	55.49	1.00e-51	195.00
IUUC-Tur-126519	Triticum urartu	54.34	8.00e-50	189.00
IUUC-Tme-127131	Tuber melanosporum	47.55	9.00e-41	159.00
IUUC-Tbe-128098	Tupaia belangeri	100.00	9.00e-63	231.00
IUUC-Ttr-128765	Tursiops truncatus	88.65	4.00e-95	340.00
IUUC-Uma-129533	Ustilago maydis	37.79	1.00e-31	130.00
IUUC-Vda-129741	Verticillium dahliae	41.96	9.00e-33	134.00
IUUC-Vpa-130667	Vicugna pacos	100.00	2.00e-110	391.00
IUUC-Vvi-131400	Vitis vinifera	55.42	7.00e-54	203.00
IUUC-Xtr-132526	Xenopus tropicalis	94.59	3.00e-105	373.00
IUUC-Xma-133326	Xiphophorus maculatus	89.78	3.00e-100	357.00
IUUC-Yli-134645	Yarrowia lipolytica	42.95	1.00e-34	139.00
IUUC-Zma-134968	Zea mays	54.34	4.00e-50	190.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence