iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164253.13	ENST00000296679.8	ENSP00000296679.4
ENSG00000164253.13	ENST00000515253.5	ENSP00000426499.1
ENSG00000164253.13	ENST00000507029.5	ENSP00000424287.1
ENSG00000164253.13	ENST00000511630.6	ENSP00000425563.2
ENSG00000164253.13	ENST00000507654.5	ENSP00000427291.1
ENSG00000164253.13	ENST00000509701.5	ENSP00000427652.1
ENSG00000164253.13	ENST00000511791.1	ENSP00000423540.1
ENSG00000164253.13	ENST00000505129.5	ENSP00000425249.1
ENSG00000164253.13	ENST00000506307.5	ENSP00000424327.1
ENSG00000164253.13	ENST00000509892.5	ENSP00000427219.1
ENSG00000164253.13	ENST00000513417.5	ENSP00000423462.1
ENSG00000164253.13	ENST00000514559.5	ENSP00000426937.1
ENSG00000164253.13	ENST00000503035.5	ENSP00000421166.1
ENSG00000164253.13	ENST00000511036.5	ENSP00000422510.1
ENSG00000164253.13	ENST00000504895.5	ENSP00000426141.1
ENSG00000164253.13	ENST00000509971.5	ENSP00000422922.1
ENSG00000164253.13	ENST00000506474.5	ENSP00000425813.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.40e-21	75.0	322	354

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtcla.fsdtllvsGsdDgtikvWDlrtg 33
           H + v  +a ++++ l+s+s Dg++++W+lr+ 
   Q: 322  HDSNVLHVArLPNRQLISCSEDGSVRIWELREK 354
           777777777457799**************9875 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MLRWLIGGGR EPQGLAEKSP LQTIGEEQTQ NPYTELLVLK AHHDIVRFLV QLDDYRFASA 60
GDDGIVVVWN AQTGEKLLEL NGHTQKITAI ITFPSLESCE EKNQLILTAS ADRTVIVWDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAATGAAAA GAATGGGCAG CCTAGTGGTT GCTCAGGTGA GCGCAGGTAC ACAGACCAGG 60
AAGTATCTCT GCTCCTAACC TCTCTTTATG TATGCATGAA GCTAATTGTT CAAGTCCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0032045--C:guanyl-nucleotide exchange factor complex
GO:0005765--C:lysosomal membrane
GO:0043547--P:positive regulation of GTPase activity

KEGG

hsa:55255

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001900	Ailuropoda melanoleuca	91.97	0.00e+00	877.00
IUUC-Apl-004087	Anas platyrhynchos	76.42	0.00e+00	648.00
IUUC-Aca-005359	Anolis carolinensis	72.27	0.00e+00	689.00
IUUC-Ame-010669	Astyanax mexicanus	43.50	2.00e-79	289.00
IUUC-Bta-013534	Bos taurus	89.98	0.00e+00	860.00
IUUC-Cja-019219	Callithrix jacchus	95.42	0.00e+00	883.00
IUUC-Cfa-020310	Canis familiaris	92.78	0.00e+00	853.00
IUUC-Cpo-021664	Cavia porcellus	90.39	0.00e+00	868.00
IUUC-Csa-024228	Chlorocebus sabaeus	97.17	0.00e+00	924.00
IUUC-Cho-024898	Choloepus hoffmanni	88.79	1.00e-116	413.00
IUUC-Dre-028538	Danio rerio	55.58	7.00e-131	460.00
IUUC-Dno-028861	Dasypus novemcinctus	90.46	0.00e+00	864.00
IUUC-Dor-030111	Dipodomys ordii	90.20	0.00e+00	868.00
IUUC-Ete-032444	Echinops telfairi	91.28	1.00e-168	586.00
IUUC-Eca-033676	Equus caballus	90.63	0.00e+00	860.00
IUUC-Eeu-034571	Erinaceus europaeus	81.48	0.00e+00	765.00
IUUC-Fca-035387	Felis catus	92.84	0.00e+00	880.00
IUUC-Fal-037310	Ficedula albicollis	75.23	0.00e+00	687.00
IUUC-Gmo-039224	Gadus morhua	55.30	4.00e-133	468.00
IUUC-Gga-040957	Gallus gallus	76.87	0.00e+00	702.00
IUUC-Gac-042385	Gasterosteus aculeatus	55.70	8.00e-143	500.00
IUUC-Ggo-044973	Gorilla gorilla	98.48	0.00e+00	933.00
IUUC-Itr-048784	Ictidomys tridecemlineatus	94.10	0.00e+00	635.00
IUUC-Lch-049625	Latimeria chalumnae	64.18	2.00e-175	608.00
IUUC-Loc-052368	Lepisosteus oculatus	60.09	2.00e-157	548.00
IUUC-Laf-053678	Loxodonta africana	91.25	0.00e+00	865.00
IUUC-Mcc-055184	Macaca mulatta	96.85	0.00e+00	890.00
IUUC-Meu-056165	Macropus eugenii	78.46	0.00e+00	713.00
IUUC-Mga-060184	Meleagris gallopavo	74.68	3.00e-64	237.00
IUUC-Mmr-060965	Microcebus murinus	94.77	0.00e+00	897.00
IUUC-Mdo-062702	Monodelphis domestica	86.46	0.00e+00	834.00
IUUC-Mmu-063649	Mus musculus	82.08	7.00e-119	421.00
IUUC-Mpu-065747	Mustela putorius furo	90.85	0.00e+00	869.00
IUUC-Mlu-067873	Myotis lucifugus	92.39	0.00e+00	874.00
IUUC-Nle-069670	Nomascus leucogenys	97.60	0.00e+00	926.00
IUUC-Opr-070266	Ochotona princeps	81.10	0.00e+00	767.00
IUUC-Ont-071242	Oreochromis niloticus	55.05	6.00e-141	494.00
IUUC-Oan-072879	Ornithorhynchus anatinus	86.00	0.00e+00	794.00
IUUC-Ocu-074872	Oryctolagus cuniculus	68.28	4.00e-166	577.00
IUUC-Ola-087211	Oryzias latipes	49.45	3.00e-115	408.00
IUUC-Oga-088852	Otolemur garnettii	92.59	0.00e+00	890.00
IUUC-Oar-089812	Ovis aries	89.98	0.00e+00	855.00
IUUC-Ptr-091067	Pan troglodytes	99.35	0.00e+00	942.00
IUUC-Pan-091778	Papio anubis	96.96	0.00e+00	919.00
IUUC-Psi-093932	Pelodiscus sinensis	77.40	0.00e+00	711.00
IUUC-Pfo-096845	Poecilia formosa	55.87	1.00e-138	486.00
IUUC-Pab-097892	Pongo abelii	95.90	0.00e+00	816.00
IUUC-Pca-100567	Procavia capensis	68.63	6.00e-176	610.00
IUUC-Pva-102560	Pteropus vampyrus	90.63	0.00e+00	853.00
IUUC-Rno-105662	Rattus norvegicus	86.18	0.00e+00	823.00
IUUC-Sha-107058	Sarcophilus harrisii	84.58	0.00e+00	809.00
IUUC-Sar-113643	Sorex araneus	79.64	0.00e+00	706.00
IUUC-Ssc-115791	Sus scrofa	92.16	0.00e+00	875.00
IUUC-Tgu-117145	Taeniopygia guttata	76.25	0.00e+00	699.00
IUUC-Tru-117875	Takifugu rubripes	56.36	9.00e-145	506.00
IUUC-Tsy-119030	Tarsius syrichta	93.96	0.00e+00	715.00
IUUC-Tni-119761	Tetraodon nigroviridis	55.14	2.00e-139	489.00
IUUC-Tbe-127757	Tupaia belangeri	91.54	0.00e+00	766.00
IUUC-Ttr-128762	Tursiops truncatus	94.55	0.00e+00	896.00
IUUC-Vpa-130360	Vicugna pacos	93.90	0.00e+00	891.00
IUUC-Xtr-131954	Xenopus tropicalis	64.25	5.00e-170	590.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence