iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164287.12	ENST00000296733.5	ENSP00000296733.1
ENSG00000164287.12	ENST00000381375.6	ENSP00000370781.2
ENSG00000164287.12	ENST00000322374.10	ENSP00000315720.6
ENSG00000164287.12	ENST00000513180.5	ENSP00000426776.1
ENSG00000164287.12	ENST00000507931.1	ENSP00000423919.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-12	47.7	274	305

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           + ++++++  + t l++G+  g +++WD+ t 
   Q: 274  NYISSVSWiKEgTCLAVGTSEGEVQLWDVVTK 305
           5699*****66699**************9876 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK 60
RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGGCGGTG GGAGGAGTGG GGGACCTGGA GGGAGGTGGT GAAATAGAAT GGTCCTGGGG 60
GACGGGACTC CAGGGGTTTG ACGATTAGGC GTCAAGACTG ACTTAGACCT GGGAAGAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

KEGG

hsa:166979

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001252	Ailuropoda melanoleuca	81.66	0.00e+00	878.00
IUUC-Aca-004279	Anolis carolinensis	45.99	4.00e-131	461.00
IUUC-Bta-012666	Bos taurus	77.53	0.00e+00	719.00
IUUC-Cja-019214	Callithrix jacchus	89.98	0.00e+00	963.00
IUUC-Cfa-021220	Canis familiaris	78.92	0.00e+00	767.00
IUUC-Cpo-021553	Cavia porcellus	77.07	0.00e+00	824.00
IUUC-Csa-024185	Chlorocebus sabaeus	94.61	0.00e+00	932.00
IUUC-Cho-025064	Choloepus hoffmanni	61.97	2.00e-178	618.00
IUUC-Dno-029229	Dasypus novemcinctus	79.41	0.00e+00	796.00
IUUC-Dor-030414	Dipodomys ordii	82.25	1.00e-144	506.00
IUUC-Eca-033225	Equus caballus	82.82	0.00e+00	889.00
IUUC-Eeu-035215	Erinaceus europaeus	74.90	0.00e+00	749.00
IUUC-Fca-036143	Felis catus	83.40	0.00e+00	909.00
IUUC-Gga-040300	Gallus gallus	50.42	2.00e-131	462.00
IUUC-Ggo-045256	Gorilla gorilla	98.07	0.00e+00	952.00
IUUC-Lch-050132	Latimeria chalumnae	63.67	2.00e-95	342.00
IUUC-Loc-051872	Lepisosteus oculatus	41.97	2.00e-116	413.00
IUUC-Laf-053539	Loxodonta africana	80.70	0.00e+00	818.00
IUUC-Mcc-054908	Macaca mulatta	94.41	0.00e+00	952.00
IUUC-Meu-056429	Macropus eugenii	56.48	4.00e-100	358.00
IUUC-Mga-060081	Meleagris gallopavo	58.88	3.00e-103	368.00
IUUC-Mmr-060846	Microcebus murinus	79.96	0.00e+00	829.00
IUUC-Mdo-062147	Monodelphis domestica	59.42	1.00e-178	619.00
IUUC-Mmu-063901	Mus musculus	72.25	0.00e+00	763.00
IUUC-Nle-069735	Nomascus leucogenys	89.94	0.00e+00	803.00
IUUC-Ocu-074439	Oryctolagus cuniculus	79.83	0.00e+00	777.00
IUUC-Oga-088043	Otolemur garnettii	80.50	0.00e+00	751.00
IUUC-Oar-089869	Ovis aries	77.13	0.00e+00	782.00
IUUC-Ptr-090818	Pan troglodytes	97.88	0.00e+00	1015.00
IUUC-Pan-092774	Papio anubis	94.46	0.00e+00	918.00
IUUC-Psi-093250	Pelodiscus sinensis	54.03	4.00e-166	578.00
IUUC-Pab-098227	Pongo abelii	96.53	0.00e+00	977.00
IUUC-Pva-103255	Pteropus vampyrus	81.27	0.00e+00	882.00
IUUC-Sha-107377	Sarcophilus harrisii	56.21	3.00e-150	525.00
IUUC-Ssc-115477	Sus scrofa	74.81	0.00e+00	770.00
IUUC-Tsy-118931	Tarsius syrichta	87.28	0.00e+00	908.00
IUUC-Tbe-127532	Tupaia belangeri	71.08	3.00e-131	461.00
IUUC-Ttr-128250	Tursiops truncatus	80.20	0.00e+00	669.00
IUUC-Vpa-130775	Vicugna pacos	80.70	0.00e+00	683.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence