iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164338.9	ENST00000296792.8	ENSP00000296792.4
ENSG00000164338.9	ENST00000509005.5	ENSP00000421669.1
ENSG00000164338.9	ENST00000508491.1	ENSP00000424609.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
HINT	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-28	99.6	147	178
UBD/Beta-Prp	4.00e-50	172.4	68	261

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gHt  v+ ++f  d  ++vsG+dD t+k+WD+
   Q: 147  GHTKAVHTVDFtADkYHVVSGADDYTVKLWDI 178
           8***********77799**************6 PP

UBD/Beta-Prp

   S: 13   itcvkf..spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
           +++v+f   p +++ +t+  +++i ++   ++  ++++s  +++ ++ +f +dg +lv gseD+ ++++d+s + +++ ++gh++ v +++f
   Q: 68   VSKVDFspQPPYNYAVTA--SSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDF 157
           7789**444555555555..6*********************************************************************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngk 193
            ++++++vsG +d t+++wd+++ +++  t+++h++ v+c + ++ + +l+++Gs+D tv+++d +t + +   +  h ++v+s+ + ++g 
   Q: 158  TADKYHVVSGADDYTVKLWDIPNSKEIL-TFKEHSDYVRCGCASKLNpDLFITGSYDHTVKMFDARTSESVLSVE--HGQPVESVLLFPSGG 246
           ****************************.************************************9999998884..9********999886 PP
   S: 194  elvsgsldgtvklwdl 209
            lvs+   ++vk+wd+
   Q: 247  LLVSA-GGRYVKVWDM 261
           66665.679******8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

XVIFARRSVR CVCRRLLEGP CDFYASAAEL CRVGSWHSPI NCPWVEVSRR TLWGSVETPV 60
QIKEFGAVSK VDFSPQPPYN YAVTASSRIH IYGRYSQEPI KTFSRFKDTA YCATFRQDGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTTTCGCC TTCTGGCTAA AAAACGTTCC GCAGCAATGC AGCTGAAACT TTCGGGTTTT 60
CTTTTTTTTG TCCCTCTCTC CTTTTTTTTA ATATTTTTGT TTTTGCCGCC TTTACGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR018983--U3_snoRNA-assocProt_15_C
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF09384--UTP15_C
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005730--C:nucleolus
GO:0006364--P:rRNA processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002117	Ailuropoda melanoleuca	94.02	0.00e+00	941.00
IUUC-Atr-003068	Amborella trichopoda	33.40	2.00e-67	249.00
IUUC-Apl-003926	Anas platyrhynchos	70.62	0.00e+00	708.00
IUUC-Aca-004271	Anolis carolinensis	70.53	0.00e+00	687.00
IUUC-Aly-005525	Arabidopsis lyrata	34.11	2.00e-58	220.00
IUUC-Ath-006954	Arabidopsis thaliana	33.88	2.00e-59	223.00
IUUC-Ago-007973	Ashbya gossypii	31.40	4.00e-66	245.00
IUUC-Acl-008287	Aspergillus clavatus	34.37	5.00e-58	218.00
IUUC-Afl-008504	Aspergillus flavus	34.02	5.00e-68	252.00
IUUC-Afu-008983	Aspergillus fumigatus	34.44	4.00e-56	212.00
IUUC-Ani-009315	Aspergillus nidulans	35.27	3.00e-65	243.00
IUUC-Ang-009690	Aspergillus niger	32.99	8.00e-64	238.00
IUUC-Aor-010181	Aspergillus oryzae	34.02	5.00e-68	252.00
IUUC-Ate-010498	Aspergillus terreus	33.06	9.00e-61	228.00
IUUC-Ame-011814	Astyanax mexicanus	56.79	1.00e-160	559.00
IUUC-Bgr-012273	Blumeria graminis	30.83	2.00e-69	256.00
IUUC-Bta-013068	Bos taurus	93.63	0.00e+00	933.00
IUUC-Bci-013930	Botrytis cinerea	32.46	9.00e-75	274.00
IUUC-Bdi-014876	Brachypodium distachyon	33.63	4.00e-62	232.00
IUUC-Bol-015366	Brassica oleracea	32.85	3.00e-62	232.00
IUUC-Bra-017589	Brassica rapa	32.92	9.00e-61	228.00
IUUC-Cel-018159	Caenorhabditis elegans	30.14	7.00e-63	235.00
IUUC-Cja-019139	Callithrix jacchus	96.60	0.00e+00	896.00
IUUC-Cfa-020742	Canis familiaris	89.94	0.00e+00	889.00
IUUC-Cpo-021707	Cavia porcellus	92.81	0.00e+00	916.00
IUUC-Cre-022665	Chlamydomonas reinhardtii	40.80	1.00e-88	320.00
IUUC-Csa-023024	Chlorocebus sabaeus	97.41	0.00e+00	966.00
IUUC-Cho-024487	Choloepus hoffmanni	88.97	2.00e-131	462.00
IUUC-Cin-025294	Ciona intestinalis	46.51	9.00e-133	467.00
IUUC-Cgl-026388	Colletotrichum gloeosporioides	30.02	3.00e-41	162.00
IUUC-Cne-026945	Cryptococcus neoformans	38.41	2.00e-80	293.00
IUUC-Cme-027108	Cyanidioschyzon merolae	31.12	2.00e-54	206.00
IUUC-Dre-028316	Danio rerio	58.11	4.00e-167	581.00
IUUC-Dno-028985	Dasypus novemcinctus	91.42	0.00e+00	908.00
IUUC-Dor-030219	Dipodomys ordii	78.99	5.00e-170	590.00
IUUC-Dse-031495	Dothistroma septosporum	30.35	1.00e-46	181.00
IUUC-Dme-031769	Drosophila melanogaster	38.67	1.00e-83	304.00
IUUC-Ete-032630	Echinops telfairi	80.64	0.00e+00	723.00
IUUC-Eca-033816	Equus caballus	93.01	0.00e+00	927.00
IUUC-Eeu-034840	Erinaceus europaeus	81.44	0.00e+00	744.00
IUUC-Fca-035751	Felis catus	93.01	0.00e+00	937.00
IUUC-Fal-036733	Ficedula albicollis	66.47	0.00e+00	711.00
IUUC-Fox-037743	Fusarium oxysporum	31.30	5.00e-65	242.00
IUUC-Fso-038395	Fusarium solani	31.93	2.00e-66	247.00
IUUC-Gmo-038803	Gadus morhua	61.24	4.00e-171	594.00
IUUC-Ggr-040092	Gaeumannomyces graminis	31.20	4.00e-63	236.00
IUUC-Gga-040714	Gallus gallus	67.85	0.00e+00	712.00
IUUC-Gac-042640	Gasterosteus aculeatus	60.08	1.00e-177	616.00
IUUC-Gma-044192	Glycine max	33.19	9.00e-69	254.00
IUUC-Ggo-045616	Gorilla gorilla	97.81	0.00e+00	962.00
IUUC-Itr-048796	Ictidomys tridecemlineatus	92.77	0.00e+00	914.00
IUUC-Kpa-049291	Komagataella pastoris	30.56	1.00e-62	234.00
IUUC-Lch-049729	Latimeria chalumnae	73.16	0.00e+00	694.00
IUUC-Lpe-051141	Leersia perrieri	31.97	8.00e-63	234.00
IUUC-Loc-051756	Lepisosteus oculatus	70.23	0.00e+00	689.00
IUUC-Lma-053083	Leptosphaeria maculans	30.40	2.00e-62	233.00
IUUC-Laf-054067	Loxodonta africana	90.52	0.00e+00	860.00
IUUC-Mcc-055096	Macaca mulatta	97.41	0.00e+00	966.00
IUUC-Meu-056604	Macropus eugenii	74.24	0.00e+00	736.00
IUUC-Mor-057186	Magnaporthe oryzae	31.70	9.00e-66	244.00
IUUC-Mtr-058346	Medicago truncatula	32.49	2.00e-66	246.00
IUUC-Mla-059116	Melampsora laricipopulina	35.46	1.00e-80	293.00
IUUC-Mga-060038	Meleagris gallopavo	65.56	4.00e-151	527.00
IUUC-Mvi-060272	Microbotryum violaceum	33.40	3.00e-79	289.00
IUUC-Mmr-060877	Microcebus murinus	93.21	0.00e+00	932.00
IUUC-Mdo-062168	Monodelphis domestica	80.16	0.00e+00	805.00
IUUC-Mmu-063441	Mus musculus	87.93	0.00e+00	872.00
IUUC-Mac-065330	Musa acuminata	33.83	5.00e-53	202.00
IUUC-Mpu-065704	Mustela putorius furo	93.81	0.00e+00	944.00
IUUC-Mlu-067640	Myotis lucifugus	92.22	0.00e+00	912.00
IUUC-Nfi-068589	Neosartorya fischeri	34.65	1.00e-56	214.00
IUUC-Ncr-068769	Neurospora crassa	32.71	2.00e-64	239.00
IUUC-Nle-069105	Nomascus leucogenys	90.51	0.00e+00	879.00
IUUC-Opr-070203	Ochotona princeps	89.82	0.00e+00	937.00
IUUC-Ont-072054	Oreochromis niloticus	65.50	0.00e+00	656.00
IUUC-Oan-073624	Ornithorhynchus anatinus	71.73	0.00e+00	632.00
IUUC-Ocu-074326	Oryctolagus cuniculus	92.42	0.00e+00	920.00
IUUC-Obr-076038	Oryza brachyantha	32.90	2.00e-63	236.00
IUUC-Ogl-077463	Oryza glaberrima	31.29	2.00e-56	213.00
IUUC-Ogu-078631	Oryza glumaepatula	31.95	3.00e-63	236.00
IUUC-Oin-079242	Oryza indica	31.49	2.00e-57	216.00
IUUC-Olo-080652	Oryza longistaminata	30.28	2.00e-52	200.00
IUUC-Ome-081109	Oryza meridionalis	32.19	1.00e-55	212.00
IUUC-Oni-082187	Oryza nivara	31.49	2.00e-57	216.00
IUUC-Opu-083995	Oryza punctata	32.39	2.00e-57	216.00
IUUC-Oru-084962	Oryza rufipogon	32.24	7.00e-55	208.00
IUUC-Osa-086201	Oryza sativa	32.24	7.00e-55	208.00
IUUC-Ola-087115	Oryzias latipes	63.21	0.00e+00	643.00
IUUC-Olu-087842	Ostreococcus lucimarinus	34.88	1.00e-68	254.00
IUUC-Oga-088204	Otolemur garnettii	94.93	0.00e+00	937.00
IUUC-Oar-089297	Ovis aries	93.44	0.00e+00	927.00
IUUC-Ptr-090953	Pan troglodytes	97.60	0.00e+00	967.00
IUUC-Pan-092451	Papio anubis	96.61	0.00e+00	952.00
IUUC-Psi-092999	Pelodiscus sinensis	72.56	0.00e+00	726.00
IUUC-Pma-094304	Petromyzon marinus	47.11	2.00e-119	422.00
IUUC-Pno-095060	Phaeosphaeria nodorum	32.77	4.00e-64	239.00
IUUC-Ppa-095433	Physcomitrella patens	36.99	4.00e-91	328.00
IUUC-Pfo-096433	Poecilia formosa	63.45	3.00e-179	621.00
IUUC-Pab-098677	Pongo abelii	97.41	0.00e+00	967.00
IUUC-Pop-099329	Populus trichocarpa	34.64	3.00e-64	239.00
IUUC-Pca-100444	Procavia capensis	81.44	0.00e+00	736.00
IUUC-Ppe-101318	Prunus persica	32.89	4.00e-75	275.00
IUUC-Pva-102162	Pteropus vampyrus	83.63	0.00e+00	845.00
IUUC-Pgr-103329	Puccinia graminis	40.31	7.00e-63	235.00
IUUC-Ptt-103837	Puccinia triticina	32.97	1.00e-77	283.00
IUUC-Pte-104133	Pyrenophora teres	30.96	2.00e-63	236.00
IUUC-Pyt-104675	Pyrenophora triticirepentis	30.87	6.00e-63	235.00
IUUC-Rno-105004	Rattus norvegicus	89.74	0.00e+00	886.00
IUUC-Sce-106443	Saccharomyces cerevisiae	31.02	2.00e-64	239.00
IUUC-Sha-107199	Sarcophilus harrisii	79.27	0.00e+00	792.00
IUUC-Sja-107670	Schizosaccharomyces japonicus	38.40	4.00e-92	332.00
IUUC-Spo-108125	Schizosaccharomyces pombe	37.05	2.00e-85	310.00
IUUC-Ssl-108534	Sclerotinia sclerotiorum	32.06	2.00e-73	270.00
IUUC-Smo-109588	Selaginella moellendorffii	36.51	2.00e-87	316.00
IUUC-Sit-110043	Setaria italica	30.37	8.00e-47	181.00
IUUC-Stu-112396	Solanum tuberosum	35.84	4.00e-82	298.00
IUUC-Sar-113359	Sorex araneus	91.34	3.00e-170	590.00
IUUC-Sre-114995	Sporisorium reilianum	34.81	1.00e-84	307.00
IUUC-Ssc-115397	Sus scrofa	93.61	0.00e+00	934.00
IUUC-Tgu-116834	Taeniopygia guttata	66.87	0.00e+00	710.00
IUUC-Tru-118764	Takifugu rubripes	62.81	0.00e+00	642.00
IUUC-Tsy-119118	Tarsius syrichta	94.81	0.00e+00	946.00
IUUC-Tni-120053	Tetraodon nigroviridis	64.05	0.00e+00	654.00
IUUC-Tca-121842	Theobroma cacao	35.71	1.00e-72	267.00
IUUC-Tre-122172	Trichoderma reesei	34.03	4.00e-70	259.00
IUUC-Tvi-122288	Trichoderma virens	32.98	4.00e-58	219.00
IUUC-Tae-125722	Triticum aestivum	33.42	2.00e-50	193.00
IUUC-Tur-126846	Triticum urartu	31.07	2.00e-29	123.00
IUUC-Tme-127164	Tuber melanosporum	32.78	5.00e-73	268.00
IUUC-Tbe-127458	Tupaia belangeri	96.11	0.00e+00	935.00
IUUC-Ttr-128680	Tursiops truncatus	93.63	0.00e+00	900.00
IUUC-Uma-129508	Ustilago maydis	35.19	1.00e-84	307.00
IUUC-Vda-129696	Verticillium dahliae	29.50	4.00e-57	216.00
IUUC-Vpa-130820	Vicugna pacos	92.02	0.00e+00	920.00
IUUC-Vvi-131126	Vitis vinifera	35.07	9.00e-85	307.00
IUUC-Xtr-131826	Xenopus tropicalis	65.35	0.00e+00	687.00
IUUC-Xma-133373	Xiphophorus maculatus	64.46	0.00e+00	635.00
IUUC-Yli-134432	Yarrowia lipolytica	31.82	4.00e-69	255.00
IUUC-Zma-135241	Zea mays	31.92	6.00e-56	211.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence