iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164934.13	ENST00000297579.9	ENSP00000297579.5
ENSG00000164934.13	ENST00000521971.5	ENSP00000430883.2
ENSG00000164934.13	ENST00000519682.5	ENSP00000430411.2
ENSG00000164934.13	ENST00000618975.1	ENSP00000480810.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.80e-21	75.1	216	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtl..lvsGsdDgtikvWDlrtgvllk 37
           gH d+v+cla  +++l  ++sG+ Dg +++W+l++ ++++
   Q: 216  GHRDGVNCLAKhPEKLatVLSGACDGEVRIWNLTQRNCIR 255
           8********855653344899**************99987 PP

Organism

Homo sapiens

Functional Description
(View)

Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MQWPPPWRRS PLVSATPPPG PTRGLLCPRR VSEAGDSSTE GARTGHRHYV TPAESAMEGR 60
SQPLPSLRPA SPTNAPAHGR GSDCTAKEPP LANVCRQNYG AAQDPVEPAG RRSASHVTGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAGACGGA GGAGATCCAG TTCGGGCTGA CAGTGAGAGG ATGCAGCCCG GTGTCTGGGC 60
GGGCTCTTAC CGGCGAAGCG GATCTTCACG AGGTCGAGCG GATGCAGCGC AAGGTTGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR007287--Sof1
IPR013979--TIF_beta_prop-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08662--eIF2A
PF04158--Sof1
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0030054--C:cell junction
GO:0005813--C:centrosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032040--C:small-subunit processome
GO:0030331--F:estrogen receptor binding
GO:0003723--F:RNA binding
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0016567--P:protein ubiquitination
GO:0006364--P:rRNA processing

KEGG

hsa:25879

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002178	Ailuropoda melanoleuca	95.43	0.00e+00	881.00
IUUC-Atr-002799	Amborella trichopoda	47.95	3.00e-131	461.00
IUUC-Apl-003675	Anas platyrhynchos	85.09	0.00e+00	769.00
IUUC-Aca-004792	Anolis carolinensis	86.44	0.00e+00	817.00
IUUC-Aly-005998	Arabidopsis lyrata	47.60	1.00e-128	452.00
IUUC-Ath-007526	Arabidopsis thaliana	47.60	4.00e-128	451.00
IUUC-Ago-007774	Ashbya gossypii	46.59	1.00e-116	413.00
IUUC-Acl-008024	Aspergillus clavatus	44.20	3.00e-105	375.00
IUUC-Afu-008930	Aspergillus fumigatus	43.42	2.00e-103	369.00
IUUC-Ani-009370	Aspergillus nidulans	42.99	4.00e-104	371.00
IUUC-Ang-009827	Aspergillus niger	45.18	4.00e-108	385.00
IUUC-Aor-010060	Aspergillus oryzae	43.98	2.00e-100	359.00
IUUC-Ate-010434	Aspergillus terreus	45.15	6.00e-91	327.00
IUUC-Ame-011967	Astyanax mexicanus	73.49	0.00e+00	701.00
IUUC-Bgr-011989	Blumeria graminis	44.68	7.00e-107	380.00
IUUC-Bta-013291	Bos taurus	68.56	5.00e-177	613.00
IUUC-Bci-013868	Botrytis cinerea	42.99	2.00e-103	369.00
IUUC-Bdi-014343	Brachypodium distachyon	49.43	1.00e-124	439.00
IUUC-Bol-015740	Brassica oleracea	46.00	8.00e-119	420.00
IUUC-Bra-016689	Brassica rapa	45.77	5.00e-117	414.00
IUUC-Cel-018536	Caenorhabditis elegans	49.64	1.00e-121	430.00
IUUC-Cja-018779	Callithrix jacchus	97.70	0.00e+00	905.00
IUUC-Cfa-020105	Canis familiaris	97.01	0.00e+00	897.00
IUUC-Cpo-021538	Cavia porcellus	92.73	0.00e+00	848.00
IUUC-Cre-022798	Chlamydomonas reinhardtii	51.63	3.00e-45	174.00
IUUC-Csa-023492	Chlorocebus sabaeus	98.20	0.00e+00	927.00
IUUC-Cho-024497	Choloepus hoffmanni	84.47	1.00e-154	539.00
IUUC-Cin-025524	Ciona intestinalis	62.39	4.00e-169	587.00
IUUC-Csv-026197	Ciona savignyi	63.30	3.00e-172	598.00
IUUC-Cgl-026745	Colletotrichum gloeosporioides	39.72	4.00e-92	331.00
IUUC-Cne-026840	Cryptococcus neoformans	36.72	2.00e-78	288.00
IUUC-Cme-027111	Cyanidioschyzon merolae	35.13	2.00e-73	270.00
IUUC-Dre-027471	Danio rerio	74.42	0.00e+00	721.00
IUUC-Dno-029790	Dasypus novemcinctus	91.14	0.00e+00	698.00
IUUC-Dor-030971	Dipodomys ordii	65.76	0.00e+00	713.00
IUUC-Dse-031563	Dothistroma septosporum	44.37	4.00e-103	368.00
IUUC-Dme-032161	Drosophila melanogaster	58.49	2.00e-159	555.00
IUUC-Ete-033127	Echinops telfairi	77.46	0.00e+00	882.00
IUUC-Eca-033531	Equus caballus	95.89	0.00e+00	844.00
IUUC-Eeu-034663	Erinaceus europaeus	68.58	0.00e+00	758.00
IUUC-Fca-036258	Felis catus	97.24	0.00e+00	900.00
IUUC-Fal-037456	Ficedula albicollis	87.82	0.00e+00	778.00
IUUC-Fox-038025	Fusarium oxysporum	43.39	6.00e-102	364.00
IUUC-Fso-038344	Fusarium solani	43.95	3.00e-99	355.00
IUUC-Gmo-039643	Gadus morhua	75.40	0.00e+00	731.00
IUUC-Ggr-039816	Gaeumannomyces graminis	44.58	1.00e-102	366.00
IUUC-Gga-040143	Gallus gallus	88.74	0.00e+00	813.00
IUUC-Gac-041665	Gasterosteus aculeatus	76.67	0.00e+00	740.00
IUUC-Gma-043073	Glycine max	47.37	1.00e-124	439.00
IUUC-Ggo-045058	Gorilla gorilla	96.63	0.00e+00	1137.00
IUUC-Hvu-047654	Hordeum vulgare	50.00	6.00e-74	270.00
IUUC-Itr-048822	Ictidomys tridecemlineatus	95.40	0.00e+00	883.00
IUUC-Kpa-049232	Komagataella pastoris	46.95	1.00e-119	422.00
IUUC-Lch-050542	Latimeria chalumnae	78.35	0.00e+00	780.00
IUUC-Lpe-051622	Leersia perrieri	49.43	5.00e-127	447.00
IUUC-Loc-052674	Lepisosteus oculatus	75.28	0.00e+00	714.00
IUUC-Lma-053108	Leptosphaeria maculans	42.69	5.00e-103	368.00
IUUC-Laf-053385	Loxodonta africana	94.94	0.00e+00	863.00
IUUC-Mcc-055151	Macaca mulatta	97.93	0.00e+00	908.00
IUUC-Meu-056230	Macropus eugenii	90.95	3.00e-119	422.00
IUUC-Mor-057013	Magnaporthe oryzae	42.79	4.00e-98	351.00
IUUC-Mpo-057530	Magnaporthe poae	44.58	2.00e-103	369.00
IUUC-Mtr-058187	Medicago truncatula	47.83	1.00e-126	446.00
IUUC-Mla-058964	Melampsora laricipopulina	39.96	1.00e-93	337.00
IUUC-Mga-059712	Meleagris gallopavo	88.25	0.00e+00	773.00
IUUC-Mvi-060370	Microbotryum violaceum	40.14	5.00e-67	248.00
IUUC-Mmr-061340	Microcebus murinus	79.93	0.00e+00	862.00
IUUC-Mdo-062978	Monodelphis domestica	88.05	0.00e+00	827.00
IUUC-Mmu-063439	Mus musculus	93.10	0.00e+00	865.00
IUUC-Mac-065129	Musa acuminata	47.61	5.00e-129	454.00
IUUC-Mpu-066548	Mustela putorius furo	86.39	0.00e+00	704.00
IUUC-Mlu-067660	Myotis lucifugus	96.09	0.00e+00	894.00
IUUC-Nfi-068455	Neosartorya fischeri	44.69	7.00e-107	380.00
IUUC-Ncr-068848	Neurospora crassa	42.43	9.00e-94	337.00
IUUC-Nle-069923	Nomascus leucogenys	95.74	0.00e+00	1160.00
IUUC-Opr-070279	Ochotona princeps	81.58	2.00e-89	323.00
IUUC-Ont-072234	Oreochromis niloticus	77.47	0.00e+00	743.00
IUUC-Oan-073713	Ornithorhynchus anatinus	83.51	1.00e-101	361.00
IUUC-Ocu-073782	Oryctolagus cuniculus	95.17	0.00e+00	880.00
IUUC-Oba-075161	Oryza barthii	49.43	3.00e-127	448.00
IUUC-Obr-076868	Oryza brachyantha	49.54	4.00e-127	447.00
IUUC-Ogl-077062	Oryza glaberrima	49.43	3.00e-127	448.00
IUUC-Ogu-078308	Oryza glumaepatula	49.43	2.00e-127	448.00
IUUC-Oin-079378	Oryza indica	49.43	2.00e-127	448.00
IUUC-Olo-080638	Oryza longistaminata	46.92	3.00e-117	415.00
IUUC-Oni-082368	Oryza nivara	49.43	2.00e-127	448.00
IUUC-Opu-083628	Oryza punctata	49.43	2.00e-127	448.00
IUUC-Oru-085226	Oryza rufipogon	49.20	7.00e-127	447.00
IUUC-Osa-085368	Oryza sativa	44.65	5.00e-68	250.00
IUUC-Ola-086836	Oryzias latipes	79.08	0.00e+00	759.00
IUUC-Olu-087755	Ostreococcus lucimarinus	45.54	5.00e-125	441.00
IUUC-Oga-088170	Otolemur garnettii	95.40	0.00e+00	887.00
IUUC-Oar-089388	Ovis aries	91.85	0.00e+00	879.00
IUUC-Ptr-090494	Pan troglodytes	93.36	0.00e+00	1134.00
IUUC-Pan-091697	Papio anubis	94.28	0.00e+00	1011.00
IUUC-Psi-093916	Pelodiscus sinensis	83.45	0.00e+00	762.00
IUUC-Pno-095004	Phaeosphaeria nodorum	40.55	5.00e-93	334.00
IUUC-Ppa-095514	Physcomitrella patens	48.98	2.00e-131	462.00
IUUC-Pfo-097432	Poecilia formosa	78.74	0.00e+00	734.00
IUUC-Pab-098423	Pongo abelii	98.65	0.00e+00	929.00
IUUC-Pop-099649	Populus trichocarpa	48.51	4.00e-129	454.00
IUUC-Pca-100365	Procavia capensis	76.79	0.00e+00	863.00
IUUC-Ppe-101379	Prunus persica	46.68	3.00e-125	441.00
IUUC-Pva-102845	Pteropus vampyrus	81.79	0.00e+00	940.00
IUUC-Pgr-103469	Puccinia graminis	35.27	8.00e-83	301.00
IUUC-Ptt-103980	Puccinia triticina	37.28	3.00e-62	232.00
IUUC-Pte-104111	Pyrenophora teres	42.05	8.00e-100	357.00
IUUC-Pyt-104610	Pyrenophora triticirepentis	42.18	4.00e-100	358.00
IUUC-Rno-105082	Rattus norvegicus	92.64	0.00e+00	867.00
IUUC-Sce-106340	Saccharomyces cerevisiae	45.63	1.00e-117	417.00
IUUC-Sha-106584	Sarcophilus harrisii	88.51	0.00e+00	831.00
IUUC-Sja-107703	Schizosaccharomyces japonicus	43.48	1.00e-100	359.00
IUUC-Spo-108046	Schizosaccharomyces pombe	45.89	1.00e-104	373.00
IUUC-Ssl-108574	Sclerotinia sclerotiorum	43.45	3.00e-104	372.00
IUUC-Smo-109548	Selaginella moellendorffii	46.68	7.00e-126	444.00
IUUC-Sit-110242	Setaria italica	48.29	1.00e-123	436.00
IUUC-Sly-111762	Solanum lycopersicum	47.37	4.00e-125	441.00
IUUC-Stu-112156	Solanum tuberosum	47.37	3.00e-124	438.00
IUUC-Sbi-114739	Sorghum bicolor	49.66	2.00e-125	442.00
IUUC-Sre-114951	Sporisorium reilianum	39.92	8.00e-103	367.00
IUUC-Ssc-115510	Sus scrofa	96.09	0.00e+00	890.00
IUUC-Tgu-117234	Taeniopygia guttata	87.62	0.00e+00	733.00
IUUC-Tru-117986	Takifugu rubripes	76.99	0.00e+00	742.00
IUUC-Tsy-119252	Tarsius syrichta	82.76	0.00e+00	936.00
IUUC-Tni-119785	Tetraodon nigroviridis	77.46	0.00e+00	718.00
IUUC-Tca-121222	Theobroma cacao	47.14	8.00e-124	437.00
IUUC-Tre-122243	Trichoderma reesei	43.72	5.00e-101	361.00
IUUC-Tvi-122293	Trichoderma virens	43.49	5.00e-99	354.00
IUUC-Tae-124591	Triticum aestivum	47.48	4.00e-112	398.00
IUUC-Tur-126098	Triticum urartu	46.33	6.00e-108	384.00
IUUC-Tme-127200	Tuber melanosporum	47.30	2.00e-121	429.00
IUUC-Tbe-127568	Tupaia belangeri	96.90	3.00e-134	471.00
IUUC-Ttr-129185	Tursiops truncatus	80.04	0.00e+00	825.00
IUUC-Uma-129353	Ustilago maydis	40.33	2.00e-102	365.00
IUUC-Vda-129768	Verticillium dahliae	42.66	2.00e-97	349.00
IUUC-Vpa-130572	Vicugna pacos	82.71	0.00e+00	986.00
IUUC-Vvi-131555	Vitis vinifera	47.83	2.00e-125	442.00
IUUC-Xtr-132263	Xenopus tropicalis	80.22	0.00e+00	640.00
IUUC-Xma-133925	Xiphophorus maculatus	78.97	0.00e+00	737.00
IUUC-Yli-134384	Yarrowia lipolytica	46.15	1.00e-112	400.00
IUUC-Zma-135616	Zea mays	49.43	1.00e-124	440.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence