iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165338.16	ENST00000371681.8	ENSP00000360746.4
ENSG00000165338.16	ENST00000298068.9	ENSP00000298068.5
ENSG00000165338.16	ENST00000446394.5	ENSP00000401023.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	20175895; 19214206

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	3.40e-102	344.0	438	776

Active Site

Position(s)	Description	Evidence
744	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f+y+++++++++ + +      ++ + F+++G+l+g+a++++  ld++++
   Q: 438  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKC-----DNYSEFRLVGILMGLAVYNSITLDIRFP 524
           589***************************************************87766.....789************************* PP
   S: 94   ksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
           +++yk+ll+               +++++dl +++pel++ l e++++ e ++ee  +  tf+v +e++g +k+++LkpgG++i+Vtn+N++
   Q: 525  PCCYKKLLSPpiipsdqnipvgicNVTVDDLCQIMPELAHGLSELLSH-EGNVEED-FYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRK 614
           **********777777766666666*********************98.6788885.*********************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++++d+++l++ t+y+g y +++ +i++Fw+v+ +f  + +k+
   Q: 615  EYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG-YAKTDLTIKYFWDVVLGFPLDLQKK 705
           ****************************************************************76.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +L+F+Tgs+r+P+gG+a+l+   f i+k ++s++ lP ++TCfn+L+LP+Y+sk+ lk+kL++ i++++gF+l+
   Q: 706  LLHFTTGSDRVPVGGMADLN---FKISKnETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 776
           ********************...9999966777**************************************985 PP

Organism

Homo sapiens

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSEAVRVPSP ATPLVVAAPA PEERKGKESE REKLPPIVSA GAGATAGLDR GAKGQISTFS 60
SFISAVSPKK EAAENRSSPA HLVFPNIKNV REPPPICLDV RQKQRTSMDA SSSEMKAPVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGGAAAGG AAATTGTCTA GGTGTCCTGG TGGTGGAGGT GGGGGGTATT TTAATTTCAT 60
AATTAAAAGC TCTCTTCTTC GGCTTTCAAG TTTTTACTCC TATTTGTAAT GATTTGATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

KEGG

hsa:143279

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	95.10	0.00e+00	1457.00
IUUC-Apl-003589	Anas platyrhynchos	84.95	0.00e+00	1285.00
IUUC-Aca-004350	Anolis carolinensis	79.95	0.00e+00	1211.00
IUUC-Ago-007908	Ashbya gossypii	34.60	6.00e-83	302.00
IUUC-Acl-008288	Aspergillus clavatus	34.70	1.00e-97	352.00
IUUC-Afl-008402	Aspergillus flavus	33.88	1.00e-91	330.00
IUUC-Afu-008762	Aspergillus fumigatus	33.99	6.00e-95	342.00
IUUC-Ani-009176	Aspergillus nidulans	34.72	2.00e-93	337.00
IUUC-Ang-009791	Aspergillus niger	35.04	2.00e-93	337.00
IUUC-Aor-009921	Aspergillus oryzae	33.50	1.00e-90	328.00
IUUC-Ate-010295	Aspergillus terreus	35.16	1.00e-100	361.00
IUUC-Ame-010660	Astyanax mexicanus	81.61	2.00e-150	524.00
IUUC-Bgr-011981	Blumeria graminis	31.86	2.00e-95	344.00
IUUC-Bta-012945	Bos taurus	93.51	0.00e+00	1422.00
IUUC-Bci-013697	Botrytis cinerea	33.06	2.00e-81	298.00
IUUC-Cja-019263	Callithrix jacchus	97.18	0.00e+00	1471.00
IUUC-Cfa-020486	Canis familiaris	96.43	0.00e+00	1312.00
IUUC-Cpo-021755	Cavia porcellus	92.99	0.00e+00	1442.00
IUUC-Csa-023814	Chlorocebus sabaeus	98.71	0.00e+00	1413.00
IUUC-Cho-024980	Choloepus hoffmanni	77.71	0.00e+00	1157.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	42.05	4.00e-99	356.00
IUUC-Dre-028551	Danio rerio	74.83	0.00e+00	1152.00
IUUC-Dno-029497	Dasypus novemcinctus	92.61	0.00e+00	1287.00
IUUC-Dor-030867	Dipodomys ordii	81.76	0.00e+00	1189.00
IUUC-Dse-031239	Dothistroma septosporum	29.27	3.00e-90	327.00
IUUC-Ete-032902	Echinops telfairi	78.65	0.00e+00	1187.00
IUUC-Eca-033678	Equus caballus	94.93	0.00e+00	1432.00
IUUC-Eeu-035262	Erinaceus europaeus	77.41	0.00e+00	1058.00
IUUC-Fca-035590	Felis catus	95.21	0.00e+00	1461.00
IUUC-Fal-037123	Ficedula albicollis	80.39	0.00e+00	1239.00
IUUC-Fox-037941	Fusarium oxysporum	39.68	2.00e-101	364.00
IUUC-Fso-038388	Fusarium solani	40.28	6.00e-104	372.00
IUUC-Gmo-039553	Gadus morhua	66.46	0.00e+00	853.00
IUUC-Ggr-040110	Gaeumannomyces graminis	31.98	2.00e-100	361.00
IUUC-Gga-040406	Gallus gallus	84.32	0.00e+00	1325.00
IUUC-Gac-042141	Gasterosteus aculeatus	75.22	0.00e+00	1107.00
IUUC-Ggo-045504	Gorilla gorilla	98.97	0.00e+00	1508.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	88.52	0.00e+00	1235.00
IUUC-Kpa-049152	Komagataella pastoris	33.98	5.00e-78	286.00
IUUC-Lch-049824	Latimeria chalumnae	80.43	0.00e+00	1107.00
IUUC-Loc-052173	Lepisosteus oculatus	78.04	0.00e+00	1206.00
IUUC-Laf-054017	Loxodonta africana	94.18	0.00e+00	1345.00
IUUC-Mcc-055713	Macaca mulatta	97.98	0.00e+00	1461.00
IUUC-Meu-056212	Macropus eugenii	68.50	4.00e-115	408.00
IUUC-Mor-057045	Magnaporthe oryzae	36.59	2.00e-92	334.00
IUUC-Mla-059187	Melampsora laricipopulina	43.83	4.00e-88	318.00
IUUC-Mga-059884	Meleagris gallopavo	78.83	0.00e+00	1167.00
IUUC-Mmr-061344	Microcebus murinus	92.80	0.00e+00	1419.00
IUUC-Mdo-062653	Monodelphis domestica	87.05	0.00e+00	1327.00
IUUC-Mmu-063775	Mus musculus	90.22	0.00e+00	1305.00
IUUC-Mpu-066069	Mustela putorius furo	96.37	0.00e+00	1342.00
IUUC-Mlu-067925	Myotis lucifugus	93.84	0.00e+00	1394.00
IUUC-Nfi-068439	Neosartorya fischeri	33.99	3.00e-95	343.00
IUUC-Ncr-068903	Neurospora crassa	37.07	4.00e-94	340.00
IUUC-Nle-070046	Nomascus leucogenys	98.13	0.00e+00	1506.00
IUUC-Opr-071085	Ochotona princeps	79.19	2.00e-137	483.00
IUUC-Ont-072126	Oreochromis niloticus	72.32	0.00e+00	1166.00
IUUC-Oan-072933	Ornithorhynchus anatinus	88.87	0.00e+00	1192.00
IUUC-Ocu-073800	Oryctolagus cuniculus	95.92	0.00e+00	1318.00
IUUC-Ola-086988	Oryzias latipes	75.69	0.00e+00	1118.00
IUUC-Oga-088117	Otolemur garnettii	95.17	0.00e+00	1140.00
IUUC-Oar-089371	Ovis aries	93.42	0.00e+00	1383.00
IUUC-Ptr-090551	Pan troglodytes	98.46	0.00e+00	1450.00
IUUC-Pan-092067	Papio anubis	98.51	0.00e+00	1466.00
IUUC-Psi-092963	Pelodiscus sinensis	84.93	0.00e+00	1276.00
IUUC-Pfo-096562	Poecilia formosa	69.97	0.00e+00	1126.00
IUUC-Pab-098680	Pongo abelii	98.97	0.00e+00	1508.00
IUUC-Pca-100986	Procavia capensis	75.17	0.00e+00	909.00
IUUC-Pva-102219	Pteropus vampyrus	79.29	0.00e+00	1095.00
IUUC-Pgr-103315	Puccinia graminis	36.21	1.00e-95	344.00
IUUC-Ptt-103736	Puccinia triticina	41.49	2.00e-95	343.00
IUUC-Rno-105270	Rattus norvegicus	89.05	0.00e+00	1313.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.25	5.00e-70	259.00
IUUC-Sha-106819	Sarcophilus harrisii	89.59	0.00e+00	1375.00
IUUC-Spo-108271	Schizosaccharomyces pombe	32.47	1.00e-88	321.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	30.53	1.00e-85	311.00
IUUC-Sar-113134	Sorex araneus	85.21	0.00e+00	1241.00
IUUC-Ssc-115441	Sus scrofa	94.33	0.00e+00	1402.00
IUUC-Tgu-117166	Taeniopygia guttata	83.31	0.00e+00	1258.00
IUUC-Tsy-118898	Tarsius syrichta	82.26	0.00e+00	1152.00
IUUC-Tre-122108	Trichoderma reesei	38.18	1.00e-90	328.00
IUUC-Tvi-122644	Trichoderma virens	38.31	2.00e-95	344.00
IUUC-Tme-127004	Tuber melanosporum	34.40	9.00e-104	372.00
IUUC-Tbe-127292	Tupaia belangeri	78.22	0.00e+00	1084.00
IUUC-Ttr-128352	Tursiops truncatus	90.82	0.00e+00	1353.00
IUUC-Vda-129969	Verticillium dahliae	40.44	2.00e-95	344.00
IUUC-Vpa-130218	Vicugna pacos	92.21	0.00e+00	1022.00
IUUC-Xtr-132594	Xenopus tropicalis	77.47	0.00e+00	1189.00
IUUC-Xma-134157	Xiphophorus maculatus	74.81	0.00e+00	1048.00
IUUC-Yli-134470	Yarrowia lipolytica	34.55	1.00e-78	288.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence