iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165521.15	ENST00000554922.5	ENSP00000451998.1
ENSG00000165521.15	ENST00000553526.5	ENSP00000450965.1
ENSG00000165521.15	ENST00000380664.9	ENSP00000370039.5
ENSG00000165521.15	ENST00000555823.1	ENSP00000452030.1
ENSG00000165521.15	ENST00000553281.5	ENSP00000452360.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-56	187.9	1700	1732
UBD/Beta-Prp	2.80e-138	461.8	726	940

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htd.svtclaf.sd.tllvsGsdDgtikvWDlr 31
           H d ++++la  ++ ++++s++ Dgt+++WD+ 
   Q: 1700 HVDgPIWGLAThPSrDFFLSAAEDGTVRLWDIA 1732
           5553699999898889***************75 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatg..srdgtikvwdvttgkllrslsgh.eaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkghed 95
           h++ i c++++p k+++atg  +rd +i +wd++t k l+ l+gh + +v+av+fs dgk l++++ D  +t+ +wd ++g+ +++ +g +d
   Q: 726  HDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHhQYGVSAVDFSADGKRLASVGIDdsHTVVLWDWKKGEKLSIARGSKD 817
           4555566************95569******************7651669***************9999999********************* PP
   S: 96   svlslsfspsg.dklvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           ++  ++++p+  dkl++++  +  + w    g  +         g++++ +c+v+  ++ + +sG+  + v +W  +  +l++t +  h+++
   Q: 818  KIFVVKMNPYVpDKLITAG-IKHMKFWRKAGGGLIGRkgyiGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW--RDIFLVKTVKA-HDGP 905
           *********9978888887.9999***88888888779998455677799************************..889******98.**** PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgecvrtln 219
           v s+   +  k +v+g++dg v lwd + ++c++t+ 
   Q: 906  VFSMHALE--KGFVTGGKDGIVALWDDSFERCLKTYA 940
           ****9888..67**********************996 PP

Organism

Homo sapiens

Functional Description
(View)

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Protein Sequence
(Fasta)

MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR EHRQKFYRGH 60
SDDIISLALH PERVLVATGQ VGKEPYICIW DSYTVQTISV LKDVHTHGIA CLAFDLDGQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGGCATCC ACTTGACAGC CGGCGGCGCT CGCGGCCCTC AGCATGTTCC GCGAGGCGAG 60
GGTTTTCCTC CCGCCTGTGG GCTGAGGCGG CGGCGGCCCC CGAAACGAGA TGCACCTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR005108--HELP
IPR011041--Quinoprot_gluc/sorb_DH
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF03451--HELP
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0003824--F:catalytic activity
GO:0008017--F:microtubule binding

KEGG

hsa:161436

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002225	Ailuropoda melanoleuca	96.47	0.00e+00	3844.00
IUUC-Apl-003360	Anas platyrhynchos	91.17	0.00e+00	3560.00
IUUC-Ame-011681	Astyanax mexicanus	84.97	0.00e+00	3512.00
IUUC-Bta-012838	Bos taurus	96.36	0.00e+00	3881.00
IUUC-Cja-019068	Callithrix jacchus	98.84	0.00e+00	3930.00
IUUC-Cfa-020531	Canis familiaris	96.46	0.00e+00	3907.00
IUUC-Cpo-022304	Cavia porcellus	93.05	0.00e+00	3634.00
IUUC-Csa-023621	Chlorocebus sabaeus	98.42	0.00e+00	3589.00
IUUC-Cho-024944	Choloepus hoffmanni	77.14	0.00e+00	1509.00
IUUC-Dre-028772	Danio rerio	84.72	0.00e+00	3510.00
IUUC-Dno-030063	Dasypus novemcinctus	95.31	0.00e+00	3820.00
IUUC-Dor-030980	Dipodomys ordii	86.98	0.00e+00	1579.00
IUUC-Ete-032554	Echinops telfairi	93.38	0.00e+00	1050.00
IUUC-Eca-033909	Equus caballus	97.00	0.00e+00	3585.00
IUUC-Eeu-035180	Erinaceus europaeus	79.00	0.00e+00	1465.00
IUUC-Fal-037219	Ficedula albicollis	91.59	0.00e+00	3686.00
IUUC-Gmo-039146	Gadus morhua	80.54	0.00e+00	3313.00
IUUC-Gga-041095	Gallus gallus	90.93	0.00e+00	2655.00
IUUC-Gac-041341	Gasterosteus aculeatus	83.12	0.00e+00	3405.00
IUUC-Lch-050306	Latimeria chalumnae	84.70	0.00e+00	3180.00
IUUC-Loc-052215	Lepisosteus oculatus	85.18	0.00e+00	3558.00
IUUC-Laf-054044	Loxodonta africana	95.45	0.00e+00	3847.00
IUUC-Mcc-054733	Macaca mulatta	99.39	0.00e+00	3943.00
IUUC-Mga-059666	Meleagris gallopavo	89.94	0.00e+00	3518.00
IUUC-Mmr-060995	Microcebus murinus	97.93	0.00e+00	3902.00
IUUC-Mdo-062482	Monodelphis domestica	93.27	0.00e+00	3776.00
IUUC-Mmu-063533	Mus musculus	95.80	0.00e+00	3822.00
IUUC-Mpu-066704	Mustela putorius furo	96.46	0.00e+00	3894.00
IUUC-Mlu-067592	Myotis lucifugus	96.05	0.00e+00	3847.00
IUUC-Nle-069911	Nomascus leucogenys	99.19	0.00e+00	3932.00
IUUC-Ont-071966	Oreochromis niloticus	84.70	0.00e+00	3511.00
IUUC-Ola-086738	Oryzias latipes	84.06	0.00e+00	3460.00
IUUC-Oga-088436	Otolemur garnettii	95.06	0.00e+00	3798.00
IUUC-Oar-090153	Ovis aries	95.99	0.00e+00	3734.00
IUUC-Ptr-091008	Pan troglodytes	99.70	0.00e+00	3937.00
IUUC-Pan-092404	Papio anubis	98.94	0.00e+00	3915.00
IUUC-Psi-093417	Pelodiscus sinensis	90.76	0.00e+00	3545.00
IUUC-Pfo-096073	Poecilia formosa	84.93	0.00e+00	3518.00
IUUC-Pab-097900	Pongo abelii	99.19	0.00e+00	3932.00
IUUC-Pca-100107	Procavia capensis	81.19	0.00e+00	2555.00
IUUC-Pva-102880	Pteropus vampyrus	92.47	0.00e+00	3519.00
IUUC-Rno-106084	Rattus norvegicus	95.90	0.00e+00	3889.00
IUUC-Sha-106974	Sarcophilus harrisii	93.03	0.00e+00	3767.00
IUUC-Sar-113401	Sorex araneus	84.71	0.00e+00	1827.00
IUUC-Ssc-116057	Sus scrofa	96.30	0.00e+00	3790.00
IUUC-Tru-118444	Takifugu rubripes	83.40	0.00e+00	3429.00
IUUC-Tsy-118941	Tarsius syrichta	85.45	0.00e+00	2859.00
IUUC-Tni-120683	Tetraodon nigroviridis	83.01	0.00e+00	3281.00
IUUC-Tbe-127467	Tupaia belangeri	89.11	0.00e+00	1870.00
IUUC-Ttr-129138	Tursiops truncatus	92.15	0.00e+00	3539.00
IUUC-Vpa-130083	Vicugna pacos	90.84	0.00e+00	3454.00
IUUC-Xtr-131835	Xenopus tropicalis	88.44	0.00e+00	3660.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence