iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165912.15	ENST00000298838.10	ENSP00000298838.6
ENSG00000165912.15	ENST00000532457.5	ENSP00000431948.1
ENSG00000165912.15	ENST00000533686.5	ENSP00000433962.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.00e-13	50.8	367	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v++lydy +q+ deL++++G+ +l +  ee ++gW++g+   +g+ Gl P+n+ve 
   Q: 367  RVRALYDYAGQEADELSFRAGEELLKM-SEEDEQGWCQGQ-LQSGRIGLYPANYVEC 421
           689********************9999.999********7.99************86 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).

Protein Sequence
(Fasta)

MAPEEDAGGE ALGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW 60
ARKWRGTVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE KLQGQDSERV RAWQRGAFHR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTCCGGGA GGCCGCGGCG CGGGCCCAGG AGCGGCAGGA CTCGGGCCGG AGCGTGGCCG 60
GACCCCCACC CGCCGAGGGG CCCAGGGAGG ACGCGGTGAG TGCCCTGGAG GGGACGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028523--PACSIN3
IPR001452--SH3_domain

PROSITE

PS51741--F_BAR
PS50002--SH3

Pfam

PF00611--FCH
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00055--FCH
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019855--F:calcium channel inhibitor activity
GO:0008092--F:cytoskeletal protein binding
GO:0008289--F:lipid binding
GO:0006897--P:endocytosis
GO:0051926--P:negative regulation of calcium ion transport
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0051044--P:positive regulation of membrane protein ectodomain proteolysis
GO:0030100--P:regulation of endocytosis

KEGG

hsa:29763

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001906	Ailuropoda melanoleuca	96.10	0.00e+00	655.00
IUUC-Apl-003211	Anas platyrhynchos	64.85	0.00e+00	626.00
IUUC-Aca-004256	Anolis carolinensis	64.62	3.00e-178	618.00
IUUC-Ame-011049	Astyanax mexicanus	60.59	1.00e-153	536.00
IUUC-Bta-013322	Bos taurus	92.60	0.00e+00	774.00
IUUC-Cja-018907	Callithrix jacchus	98.58	0.00e+00	822.00
IUUC-Cfa-021126	Canis familiaris	96.46	0.00e+00	805.00
IUUC-Cpo-021491	Cavia porcellus	93.87	0.00e+00	795.00
IUUC-Csa-023107	Chlorocebus sabaeus	100.00	0.00e+00	828.00
IUUC-Dre-027933	Danio rerio	60.36	6.00e-147	514.00
IUUC-Dno-029002	Dasypus novemcinctus	95.52	0.00e+00	771.00
IUUC-Eca-033824	Equus caballus	95.52	0.00e+00	801.00
IUUC-Eeu-035122	Erinaceus europaeus	86.40	5.00e-174	603.00
IUUC-Fca-036420	Felis catus	96.46	0.00e+00	817.00
IUUC-Fal-037277	Ficedula albicollis	64.77	0.00e+00	633.00
IUUC-Gga-040941	Gallus gallus	64.99	1.00e-180	625.00
IUUC-Gac-041374	Gasterosteus aculeatus	62.44	2.00e-138	486.00
IUUC-Ggo-045211	Gorilla gorilla	99.53	0.00e+00	825.00
IUUC-Itr-047939	Ictidomys tridecemlineatus	96.23	0.00e+00	810.00
IUUC-Loc-052808	Lepisosteus oculatus	62.64	7.00e-158	550.00
IUUC-Laf-054211	Loxodonta africana	94.81	0.00e+00	764.00
IUUC-Mcc-055044	Macaca mulatta	100.00	0.00e+00	828.00
IUUC-Mga-059216	Meleagris gallopavo	64.92	0.00e+00	627.00
IUUC-Mmr-061172	Microcebus murinus	99.06	0.00e+00	831.00
IUUC-Mdo-062600	Monodelphis domestica	88.44	0.00e+00	771.00
IUUC-Mmu-063218	Mus musculus	94.34	0.00e+00	796.00
IUUC-Mpu-066819	Mustela putorius furo	96.70	0.00e+00	660.00
IUUC-Mlu-067597	Myotis lucifugus	92.34	0.00e+00	792.00
IUUC-Nle-069195	Nomascus leucogenys	99.29	0.00e+00	823.00
IUUC-Opr-071050	Ochotona princeps	95.76	0.00e+00	784.00
IUUC-Ont-071612	Oreochromis niloticus	55.25	3.00e-141	494.00
IUUC-Oan-073256	Ornithorhynchus anatinus	88.73	0.00e+00	746.00
IUUC-Ocu-074653	Oryctolagus cuniculus	96.70	0.00e+00	781.00
IUUC-Oga-089040	Otolemur garnettii	96.46	0.00e+00	819.00
IUUC-Oar-089918	Ovis aries	96.10	0.00e+00	790.00
IUUC-Ptr-091307	Pan troglodytes	100.00	0.00e+00	828.00
IUUC-Pan-092512	Papio anubis	100.00	0.00e+00	828.00
IUUC-Pfo-096881	Poecilia formosa	61.35	4.00e-154	537.00
IUUC-Pab-098620	Pongo abelii	100.00	0.00e+00	828.00
IUUC-Pva-102464	Pteropus vampyrus	92.69	0.00e+00	776.00
IUUC-Rno-106091	Rattus norvegicus	93.87	0.00e+00	792.00
IUUC-Sha-107474	Sarcophilus harrisii	89.39	0.00e+00	769.00
IUUC-Ssc-116128	Sus scrofa	95.75	0.00e+00	809.00
IUUC-Tgu-117511	Taeniopygia guttata	62.11	2.00e-176	612.00
IUUC-Tru-118005	Takifugu rubripes	61.09	7.00e-142	497.00
IUUC-Tni-119851	Tetraodon nigroviridis	65.46	7.00e-141	493.00
IUUC-Ttr-129313	Tursiops truncatus	95.75	0.00e+00	813.00
IUUC-Vpa-130760	Vicugna pacos	97.27	3.00e-101	362.00
IUUC-Xtr-132697	Xenopus tropicalis	58.10	4.00e-141	494.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence