iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.50e-11	45.0	30	92

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dv++vvg + f+ahk+vLa +  +F++lf +++l+      +++++ + p  f+ +l+F+Yt++l
   Q: 30   CDVTIVVGSRSFPAHKAVLACAAGYFQNLFlNTGLDAA---RTYVVDFITPANFEKVLSFVYTSEL 92
           9*****************************44555554...4788888***************997 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein Sequence
(Fasta)

MGMRIKLQST NHPNNLLKEL NKCRLSETMC DVTIVVGSRS FPAHKAVLAC AAGYFQNLFL 60
NTGLDAARTY VVDFITPANF EKVLSFVYTS ELFTDLINVG VIYEVAERLG MEDLLQACHS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGCGGCGG CGGCGATGGT GCTCGGGGCG CCGCAGAGCC GGGTAAGCGC GGCCAGGCCG 60
AGGGCTGCCC CTGGCCGAAG CCCGACCTTC GGCCCGGCAT TTATCTCGCT CTTGCTGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR000877--Prot_inh_BBI
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9880

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001750	Ailuropoda melanoleuca	91.99	0.00e+00	1339.00
IUUC-Apl-004082	Anas platyrhynchos	77.68	0.00e+00	1071.00
IUUC-Aca-004502	Anolis carolinensis	75.94	0.00e+00	1029.00
IUUC-Ang-009673	Aspergillus niger	32.89	1.00e-06	47.00
IUUC-Ame-010900	Astyanax mexicanus	40.45	3.00e-79	290.00
IUUC-Bta-012423	Bos taurus	92.70	0.00e+00	1297.00
IUUC-Cja-019477	Callithrix jacchus	97.05	0.00e+00	1394.00
IUUC-Cpo-021629	Cavia porcellus	91.43	0.00e+00	1226.00
IUUC-Csa-023663	Chlorocebus sabaeus	97.19	0.00e+00	1379.00
IUUC-Cho-025099	Choloepus hoffmanni	95.24	2.00e-172	599.00
IUUC-Cgl-026683	Colletotrichum gloeosporioides	33.87	1.00e-04	40.00
IUUC-Dre-027466	Danio rerio	39.49	2.00e-80	294.00
IUUC-Dno-029789	Dasypus novemcinctus	92.84	0.00e+00	1289.00
IUUC-Dor-030662	Dipodomys ordii	87.89	0.00e+00	649.00
IUUC-Ete-032846	Echinops telfairi	88.52	0.00e+00	1204.00
IUUC-Eca-033713	Equus caballus	93.12	0.00e+00	1305.00
IUUC-Fca-036094	Felis catus	81.96	0.00e+00	1061.00
IUUC-Gga-040448	Gallus gallus	74.86	0.00e+00	999.00
IUUC-Gac-041874	Gasterosteus aculeatus	46.90	3.00e-80	293.00
IUUC-Ggo-045047	Gorilla gorilla	99.16	0.00e+00	1407.00
IUUC-Itr-048491	Ictidomys tridecemlineatus	92.84	0.00e+00	1263.00
IUUC-Lch-049695	Latimeria chalumnae	62.14	0.00e+00	822.00
IUUC-Laf-053572	Loxodonta africana	92.84	0.00e+00	1294.00
IUUC-Mcc-055350	Macaca mulatta	97.61	0.00e+00	1387.00
IUUC-Meu-056693	Macropus eugenii	83.94	0.00e+00	1152.00
IUUC-Mga-059485	Meleagris gallopavo	63.60	0.00e+00	799.00
IUUC-Mmr-061798	Microcebus murinus	93.96	0.00e+00	1296.00
IUUC-Mdo-061919	Monodelphis domestica	84.92	0.00e+00	1183.00
IUUC-Mmu-064364	Mus musculus	88.22	0.00e+00	1250.00
IUUC-Mpu-066067	Mustela putorius furo	90.87	0.00e+00	1298.00
IUUC-Mlu-067302	Myotis lucifugus	92.13	0.00e+00	1288.00
IUUC-Nle-069398	Nomascus leucogenys	98.46	0.00e+00	1397.00
IUUC-Opr-070500	Ochotona princeps	88.78	0.00e+00	1241.00
IUUC-Ont-072318	Oreochromis niloticus	46.08	4.00e-75	275.00
IUUC-Oan-073319	Ornithorhynchus anatinus	82.93	9.00e-39	150.00
IUUC-Ocu-074571	Oryctolagus cuniculus	90.03	0.00e+00	1266.00
IUUC-Ola-087020	Oryzias latipes	40.83	4.00e-79	289.00
IUUC-Oga-088513	Otolemur garnettii	94.10	0.00e+00	1288.00
IUUC-Oar-089204	Ovis aries	92.98	0.00e+00	1298.00
IUUC-Ptr-091442	Pan troglodytes	99.16	0.00e+00	1406.00
IUUC-Pan-091854	Papio anubis	97.61	0.00e+00	1387.00
IUUC-Psi-093119	Pelodiscus sinensis	75.49	0.00e+00	1075.00
IUUC-Pma-094490	Petromyzon marinus	27.20	2.00e-41	163.00
IUUC-Pfo-097506	Poecilia formosa	43.41	1.00e-70	261.00
IUUC-Rno-105647	Rattus norvegicus	88.94	0.00e+00	1179.00
IUUC-Sha-107135	Sarcophilus harrisii	83.52	0.00e+00	1154.00
IUUC-Sar-113314	Sorex araneus	94.57	1.00e-160	560.00
IUUC-Ssc-115269	Sus scrofa	88.76	0.00e+00	1240.00
IUUC-Tgu-117020	Taeniopygia guttata	75.10	0.00e+00	1065.00
IUUC-Tru-118009	Takifugu rubripes	42.17	3.00e-74	273.00
IUUC-Tni-120499	Tetraodon nigroviridis	39.78	1.00e-73	270.00
IUUC-Tbe-127695	Tupaia belangeri	92.56	0.00e+00	1291.00
IUUC-Ttr-128485	Tursiops truncatus	91.15	0.00e+00	1258.00
IUUC-Xtr-132960	Xenopus tropicalis	58.70	0.00e+00	798.00
IUUC-Xma-133178	Xiphophorus maculatus	44.07	1.00e-70	261.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence