iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Uma-129483

Ensembl Protein ID

KIS69699

UniProt Accession

P0CT26; A0A0D1E0F8; Q4PCD5; URM1_USTMA

Genbank Protein ID

KIS69699.1

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

CM003144

Gene Name

URM1; UMAG_10075

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
UMAG_10075	KIS69699	KIS69699

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	42.31	3.00e-17	80.90	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ustilago maydis

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MSQDTVEIRV EFGGGTELLL APPHEKKHTL TIPRTDTAGN ETNVSFLIGH IRKNLITERE 60
ELFVDGDSVR PGILVLINNG DWELEGEGDY VLQDGDEVVF ISTLHGG 107

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Nucleotide Sequence
(Fasta)

ATGTCGCAAG ACACAGTCGA GATCCGCGTC GAGTTTGGAG GAGGCACCGA GCTTCTGCTG 60
GCACCGCCAC ACGAGAAGAA GCACACGCTG ACAATACCGC GAACCGATAC AGCTGGTAAT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0034227--P:tRNA thio-modification

KEGG

uma:UMAG_10075

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	56.86	8.00e-26	106.00
IUUC-Atr-003089	Amborella trichopoda	47.06	5.00e-22	94.00
IUUC-Apl-003382	Anas platyrhynchos	56.25	6.00e-23	96.70
IUUC-Aca-004981	Anolis carolinensis	57.84	3.00e-26	107.00
IUUC-Aly-005517	Arabidopsis lyrata	45.92	4.00e-19	84.30
IUUC-Ath-006718	Arabidopsis thaliana	60.66	6.00e-19	83.60
IUUC-Ago-007917	Ashbya gossypii	43.27	2.00e-19	85.10
IUUC-Acl-008054	Aspergillus clavatus	66.00	1.00e-15	72.40
IUUC-Afl-008704	Aspergillus flavus	54.12	6.00e-23	96.70
IUUC-Aor-009890	Aspergillus oryzae	50.96	1.00e-25	106.00
IUUC-Bta-012448	Bos taurus	55.88	8.00e-26	106.00
IUUC-Bci-013865	Botrytis cinerea	47.22	6.00e-26	107.00
IUUC-Bdi-014980	Brachypodium distachyon	56.34	1.00e-18	82.80
IUUC-Bol-016055	Brassica oleracea	52.24	8.00e-18	80.10
IUUC-Bra-016845	Brassica rapa	52.24	8.00e-18	80.10
IUUC-Cel-018485	Caenorhabditis elegans	32.71	5.00e-10	53.90
IUUC-Cja-019587	Callithrix jacchus	57.84	4.00e-26	107.00
IUUC-Cfa-020653	Canis familiaris	54.90	1.00e-25	105.00
IUUC-Cpo-021622	Cavia porcellus	57.84	4.00e-26	107.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	50.00	4.00e-23	97.40
IUUC-Csa-023756	Chlorocebus sabaeus	53.16	1.00e-16	77.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	45.28	1.00e-23	99.40
IUUC-Cne-026953	Cryptococcus neoformans	53.27	5.00e-27	111.00
IUUC-Cme-027314	Cyanidioschyzon merolae	45.63	3.00e-18	81.30
IUUC-Dre-027884	Danio rerio	56.00	8.00e-25	103.00
IUUC-Dno-029262	Dasypus novemcinctus	48.35	6.00e-17	78.20
IUUC-Dor-030601	Dipodomys ordii	59.02	7.00e-14	67.00
IUUC-Dme-031893	Drosophila melanogaster	47.66	8.00e-21	90.10
IUUC-Ete-032773	Echinops telfairi	54.37	9.00e-25	102.00
IUUC-Eca-034187	Equus caballus	56.86	6.00e-26	107.00
IUUC-Eeu-034808	Erinaceus europaeus	52.94	3.00e-24	101.00
IUUC-Fca-036107	Felis catus	55.88	1.00e-25	105.00
IUUC-Fal-036607	Ficedula albicollis	56.25	5.00e-23	97.10
IUUC-Fox-037698	Fusarium oxysporum	47.66	2.00e-25	105.00
IUUC-Gmo-039492	Gadus morhua	53.92	9.00e-24	99.80
IUUC-Ggr-039965	Gaeumannomyces graminis	49.04	5.00e-25	104.00
IUUC-Gga-041268	Gallus gallus	56.86	5.00e-26	107.00
IUUC-Gac-042111	Gasterosteus aculeatus	57.84	1.00e-25	106.00
IUUC-Gma-043240	Glycine max	59.02	1.00e-17	79.30
IUUC-Ggo-045176	Gorilla gorilla	51.25	2.00e-12	62.80
IUUC-Hsa-046077	Homo sapiens	56.86	2.00e-21	92.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	57.45	1.00e-18	82.40
IUUC-Kpa-049157	Komagataella pastoris	44.12	3.00e-17	78.20
IUUC-Lch-049889	Latimeria chalumnae	51.96	3.00e-24	101.00
IUUC-Lpe-050783	Leersia perrieri	61.67	8.00e-17	76.60
IUUC-Loc-052400	Lepisosteus oculatus	53.92	5.00e-24	100.00
IUUC-Lma-053259	Leptosphaeria maculans	50.00	5.00e-27	110.00
IUUC-Laf-053596	Loxodonta africana	56.73	3.00e-25	104.00
IUUC-Mcc-054845	Macaca mulatta	60.98	6.00e-23	97.10
IUUC-Meu-055968	Macropus eugenii	58.82	1.00e-27	112.00
IUUC-Mor-057126	Magnaporthe oryzae	47.12	4.00e-22	94.70
IUUC-Mpo-057311	Magnaporthe poae	50.96	2.00e-26	109.00
IUUC-Mtr-058266	Medicago truncatula	59.02	7.00e-18	80.10
IUUC-Mla-058847	Melampsora laricipopulina	37.50	9.00e-10	53.90
IUUC-Mga-059468	Meleagris gallopavo	56.25	3.00e-23	97.80
IUUC-Mvi-060235	Microbotryum violaceum	40.27	1.00e-21	93.60
IUUC-Mdo-061948	Monodelphis domestica	59.80	2.00e-28	115.00
IUUC-Mmu-063946	Mus musculus	57.00	7.00e-26	106.00
IUUC-Mac-064812	Musa acuminata	62.30	2.00e-17	78.60
IUUC-Mpu-066763	Mustela putorius furo	55.88	4.00e-25	104.00
IUUC-Mlu-066970	Myotis lucifugus	53.16	5.00e-17	76.60
IUUC-Ncr-068824	Neurospora crassa	51.46	6.00e-26	107.00
IUUC-Nle-069849	Nomascus leucogenys	52.50	1.00e-16	76.60
IUUC-Opr-070227	Ochotona princeps	57.84	4.00e-26	107.00
IUUC-Ont-072530	Oreochromis niloticus	57.28	1.00e-26	109.00
IUUC-Oan-073191	Ornithorhynchus anatinus	52.00	9.00e-23	96.30
IUUC-Ocu-074460	Oryctolagus cuniculus	55.88	1.00e-25	105.00
IUUC-Oba-075499	Oryza barthii	62.30	3.00e-17	79.00
IUUC-Obr-076896	Oryza brachyantha	60.66	1.00e-16	78.20
IUUC-Ogl-077834	Oryza glaberrima	62.30	2.00e-17	78.20
IUUC-Ogu-078622	Oryza glumaepatula	62.30	2.00e-17	78.20
IUUC-Oin-079358	Oryza indica	62.30	4.00e-17	79.30
IUUC-Olo-081035	Oryza longistaminata	48.48	2.00e-18	83.60
IUUC-Oni-082425	Oryza nivara	62.30	2.00e-17	78.20
IUUC-Opu-083461	Oryza punctata	50.62	2.00e-16	76.60
IUUC-Oru-084875	Oryza rufipogon	55.88	2.00e-15	71.60
IUUC-Oga-089128	Otolemur garnettii	56.86	8.00e-26	106.00
IUUC-Oar-089896	Ovis aries	55.88	8.00e-26	106.00
IUUC-Ptr-091618	Pan troglodytes	51.25	3.00e-12	62.80
IUUC-Pan-092238	Papio anubis	52.50	1.00e-16	77.00
IUUC-Psi-093879	Pelodiscus sinensis	55.88	4.00e-25	104.00
IUUC-Pma-094484	Petromyzon marinus	69.23	2.00e-20	89.00
IUUC-Ppa-095801	Physcomitrella patens	51.81	3.00e-19	84.70
IUUC-Pfo-097192	Poecilia formosa	53.92	5.00e-24	100.00
IUUC-Pab-098203	Pongo abelii	56.86	3.00e-21	91.70
IUUC-Pop-099614	Populus trichocarpa	60.66	1.00e-17	79.30
IUUC-Pca-100507	Procavia capensis	51.90	8.00e-17	76.30
IUUC-Ppe-101174	Prunus persica	47.06	4.00e-21	90.90
IUUC-Pva-102735	Pteropus vampyrus	55.88	1.00e-23	99.00
IUUC-Pgr-103510	Puccinia graminis	39.09	6.00e-12	60.80
IUUC-Ptt-103918	Puccinia triticina	37.84	2.00e-11	58.90
IUUC-Pte-104173	Pyrenophora teres	49.04	2.00e-25	105.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	49.54	9.00e-26	106.00
IUUC-Rno-105820	Rattus norvegicus	57.00	3.00e-25	104.00
IUUC-Sce-106366	Saccharomyces cerevisiae	42.31	4.00e-18	80.90
IUUC-Sja-107727	Schizosaccharomyces japonicus	46.53	2.00e-16	75.90
IUUC-Spo-108074	Schizosaccharomyces pombe	38.24	2.00e-09	52.00
IUUC-Smo-108944	Selaginella moellendorffii	47.87	7.00e-19	83.20
IUUC-Sit-110277	Setaria italica	53.66	6.00e-19	83.60
IUUC-Sly-111505	Solanum lycopersicum	48.78	1.00e-18	82.80
IUUC-Stu-112076	Solanum tuberosum	48.78	1.00e-18	82.40
IUUC-Sbi-114274	Sorghum bicolor	55.88	1.00e-17	79.70
IUUC-Sre-114953	Sporisorium reilianum	86.79	4.00e-50	187.00
IUUC-Ssc-115418	Sus scrofa	57.84	1.00e-26	108.00
IUUC-Tgu-117311	Taeniopygia guttata	56.25	6.00e-23	96.70
IUUC-Tru-118598	Takifugu rubripes	55.32	5.00e-21	90.10
IUUC-Tni-120109	Tetraodon nigroviridis	53.40	3.00e-21	91.30
IUUC-Tca-120942	Theobroma cacao	52.17	2.00e-18	81.60
IUUC-Tre-122099	Trichoderma reesei	46.88	5.00e-18	80.10
IUUC-Tvi-122285	Trichoderma virens	50.49	6.00e-22	94.00
IUUC-Tae-125193	Triticum aestivum	54.41	3.00e-17	78.20
IUUC-Tur-126677	Triticum urartu	47.50	1.00e-14	70.10
IUUC-Tme-127120	Tuber melanosporum	46.60	6.00e-25	103.00
IUUC-Tbe-128050	Tupaia belangeri	43.14	2.00e-14	68.60
IUUC-Ttr-129019	Tursiops truncatus	55.88	1.00e-25	105.00
IUUC-Vda-129690	Verticillium dahliae	40.19	1.00e-17	79.70
IUUC-Vvi-131174	Vitis vinifera	60.66	9.00e-19	82.80
IUUC-Xma-133862	Xiphophorus maculatus	53.92	5.00e-24	100.00
IUUC-Yli-134398	Yarrowia lipolytica	45.79	2.00e-18	82.00
IUUC-Zma-134964	Zea mays	48.78	2.00e-18	82.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence