iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046031

UUCD1 version

UUC-HoS-00163

Ensembl Protein ID

ENSP00000300747.5

UniProt Accession

Q6AZZ1; A6NI19; A8K551; B3KPM5; B4DVK4; Q8WZ70; Q96LE5; Q96PF7; Q9H9C2; Q9NW18; TRI68_HUMAN

Genbank Protein ID

AAL11501.1; AAL31641.1; BAA91569.1; BAB14309.1; BAF83855.1; BAG62716.1; BAG51737.1; EAW68835.1; AAH75058.1; AAI09064.1; AAF91075.1

Protein Name

E3 ubiquitin-protein ligase TRIM68; RING finger protein 137; RING-type E3 ubiquitin transferase TRIM68; SSA protein SS-56; Tripartite motif-containing protein 68

Genbank Nucleotide ID

AF360739; AF439153; AK001231; AK022923; AK291166; AK301120; AK056523; AC090719; BC075058; BC109063; AY005802

Gene Name

TRIM68; GC109; RNF137; SS56

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167333.12	ENST00000300747.9	ENSP00000300747.5
ENSG00000167333.12	ENST00000531101.5	ENSP00000431783.1
ENSG00000167333.12	ENST00000533021.1	ENSP00000436112.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18451177

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	6.30e-05	24.6	10	81
E3 activity/RING/RING	1.30e-07	33.7	16	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl...asggk......tcPvtrqplteedlvPnltlrrliqa 67
           + ee  CpI ++  r+P+ + +G+++  s++           +      tcP++r+p+++++l Pn  l +++++
   Q: 10   IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWeipG---EsqnwgyTCPLCRAPVQPRNLRPNWQLANVVEK 81
           67999**************************98554441...2355789*****************999888765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw..pglknssskefrCPlCr 46
           C+iC++ +++ p++ +CgH f+++Cl   w  pg +  ++   +CPlCr
   Q: 16   CPICMTFLRE-PMSIDCGHSFCHSCLsGLWeiPGES--QNWGYTCPLCR 61
           ********88.***************8788544444..78888*****8 PP

Organism

Homo sapiens

Functional Description
(View)

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.

Protein Sequence
(Fasta)

MDPTALVEAI VEEVACPICM TFLREPMSID CGHSFCHSCL SGLWEIPGES QNWGYTCPLC 60
RAPVQPRNLR PNWQLANVVE KVRLLRLHPG MGLKGDLCER HGEKLKMFCK EDVLIMCEAC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGGCTGCC GTCCCGCGAG CGGGGCCTAG AGCCGGGTGT AGTATTCTGG GAGCTGCGGG 60
CTACTGGGCC TGCGCTGCCG GGCTTTGGGT TCTGGGCCTC TGCCGCTCTC TGGCCCTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0050681--F:androgen receptor binding
GO:0035035--F:histone acetyltransferase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0060765--P:regulation of androgen receptor signaling pathway

KEGG

hsa:55128

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002078	Ailuropoda melanoleuca	89.48	0.00e+00	834.00
IUUC-Ang-009514	Aspergillus niger	33.68	3.00e-08	53.10
IUUC-Bta-012800	Bos taurus	83.76	0.00e+00	847.00
IUUC-Cja-019382	Callithrix jacchus	94.43	0.00e+00	870.00
IUUC-Cfa-020686	Canis familiaris	87.47	1.00e-178	619.00
IUUC-Csa-023952	Chlorocebus sabaeus	97.94	0.00e+00	894.00
IUUC-Cho-024811	Choloepus hoffmanni	78.76	0.00e+00	709.00
IUUC-Dno-029361	Dasypus novemcinctus	83.51	0.00e+00	796.00
IUUC-Dor-030703	Dipodomys ordii	82.89	0.00e+00	774.00
IUUC-Ete-033159	Echinops telfairi	88.43	3.00e-115	408.00
IUUC-Eca-033633	Equus caballus	79.31	0.00e+00	704.00
IUUC-Eeu-034686	Erinaceus europaeus	77.89	0.00e+00	723.00
IUUC-Fca-035750	Felis catus	87.06	0.00e+00	811.00
IUUC-Ggo-045524	Gorilla gorilla	99.59	0.00e+00	911.00
IUUC-Itr-048898	Ictidomys tridecemlineatus	82.89	0.00e+00	766.00
IUUC-Laf-054264	Loxodonta africana	86.13	0.00e+00	850.00
IUUC-Mcc-055388	Macaca mulatta	97.94	0.00e+00	894.00
IUUC-Mmr-060612	Microcebus murinus	82.27	0.00e+00	782.00
IUUC-Mmu-063761	Mus musculus	78.10	0.00e+00	776.00
IUUC-Mpu-066319	Mustela putorius furo	90.10	0.00e+00	840.00
IUUC-Mlu-067368	Myotis lucifugus	86.39	0.00e+00	802.00
IUUC-Nle-069702	Nomascus leucogenys	99.38	0.00e+00	912.00
IUUC-Opr-070810	Ochotona princeps	72.65	0.00e+00	638.00
IUUC-Ont-072259	Oreochromis niloticus	32.44	2.00e-67	249.00
IUUC-Oga-088935	Otolemur garnettii	84.12	0.00e+00	787.00
IUUC-Oar-089940	Ovis aries	88.87	0.00e+00	836.00
IUUC-Ptr-091056	Pan troglodytes	99.18	0.00e+00	908.00
IUUC-Pan-092165	Papio anubis	97.73	0.00e+00	889.00
IUUC-Pab-098415	Pongo abelii	99.39	1.00e-177	615.00
IUUC-Pca-100470	Procavia capensis	79.22	0.00e+00	799.00
IUUC-Pva-102603	Pteropus vampyrus	82.47	0.00e+00	754.00
IUUC-Rno-105709	Rattus norvegicus	74.89	0.00e+00	721.00
IUUC-Sar-113101	Sorex araneus	78.72	1.00e-150	525.00
IUUC-Ssc-115920	Sus scrofa	84.95	0.00e+00	807.00
IUUC-Tbe-127512	Tupaia belangeri	76.73	4.00e-167	580.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence