iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.60e-11	44.6	33	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv +vv+g  f+ahk+vLaasS++F +  l  l++s    ++++ d + p vf+ +l  +Ytg+l +
   Q: 33   CDVSIVVQGHIFRAHKAVLAASSPYFCDQVL--LKNS---RRIVLPDvMNPRVFENILLSSYTGRLVM 95
           8***************************995..4555...59***********************987 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with BDP1.

Protein Sequence
(Fasta)

MEPGTNSFRV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFRAHKAV LAASSPYFCD 60
QVLLKNSRRI VLPDVMNPRV FENILLSSYT GRLVMPAPEI VSYLTAASFL QMWHVVDKCT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGAAGCGT TTCCGGGGGC TGAAGGCACA GGCTGAATCT GTTGCGGCAG CTGAGGCTAC 60
AACAGGCCTG CGCCGGCGGC AGAGAGGATA TCTTGGGCGG GGGATGTGAG CGCTGAGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:23099

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001868	Ailuropoda melanoleuca	98.29	0.00e+00	923.00
IUUC-Apl-003386	Anas platyrhynchos	87.15	0.00e+00	818.00
IUUC-Aca-004542	Anolis carolinensis	81.58	0.00e+00	751.00
IUUC-Ame-011277	Astyanax mexicanus	46.22	2.00e-59	223.00
IUUC-Bta-013409	Bos taurus	98.07	0.00e+00	922.00
IUUC-Cja-019602	Callithrix jacchus	99.57	0.00e+00	934.00
IUUC-Cfa-020314	Canis familiaris	98.52	0.00e+00	793.00
IUUC-Cpo-021377	Cavia porcellus	97.86	0.00e+00	919.00
IUUC-Csa-023307	Chlorocebus sabaeus	99.36	0.00e+00	916.00
IUUC-Dre-027503	Danio rerio	50.11	1.00e-114	406.00
IUUC-Dno-028903	Dasypus novemcinctus	97.86	0.00e+00	922.00
IUUC-Dor-030661	Dipodomys ordii	98.50	0.00e+00	926.00
IUUC-Ete-032663	Echinops telfairi	95.72	0.00e+00	903.00
IUUC-Eca-034102	Equus caballus	98.72	0.00e+00	915.00
IUUC-Eeu-035341	Erinaceus europaeus	98.07	0.00e+00	923.00
IUUC-Fca-036322	Felis catus	98.50	0.00e+00	929.00
IUUC-Fal-036878	Ficedula albicollis	86.30	0.00e+00	811.00
IUUC-Gga-040582	Gallus gallus	86.51	0.00e+00	814.00
IUUC-Ggo-045077	Gorilla gorilla	100.00	0.00e+00	938.00
IUUC-Itr-048057	Ictidomys tridecemlineatus	98.93	0.00e+00	926.00
IUUC-Lch-050640	Latimeria chalumnae	64.50	1.00e-151	529.00
IUUC-Laf-054302	Loxodonta africana	97.43	0.00e+00	890.00
IUUC-Mcc-055468	Macaca mulatta	99.36	0.00e+00	932.00
IUUC-Mga-059461	Meleagris gallopavo	86.51	0.00e+00	814.00
IUUC-Mmr-061324	Microcebus murinus	98.50	0.00e+00	931.00
IUUC-Mdo-062288	Monodelphis domestica	92.08	0.00e+00	862.00
IUUC-Mmu-064162	Mus musculus	92.93	0.00e+00	879.00
IUUC-Mpu-066090	Mustela putorius furo	98.50	0.00e+00	927.00
IUUC-Mlu-067078	Myotis lucifugus	97.00	0.00e+00	900.00
IUUC-Nle-069869	Nomascus leucogenys	99.79	0.00e+00	937.00
IUUC-Opr-071064	Ochotona princeps	97.00	0.00e+00	914.00
IUUC-Oan-072750	Ornithorhynchus anatinus	88.01	0.00e+00	838.00
IUUC-Ocu-074818	Oryctolagus cuniculus	98.29	0.00e+00	923.00
IUUC-Oga-088464	Otolemur garnettii	98.93	0.00e+00	932.00
IUUC-Oar-090146	Ovis aries	97.42	0.00e+00	913.00
IUUC-Ptr-090947	Pan troglodytes	100.00	0.00e+00	938.00
IUUC-Pan-092109	Papio anubis	99.14	0.00e+00	931.00
IUUC-Psi-093332	Pelodiscus sinensis	88.22	0.00e+00	836.00
IUUC-Pma-094753	Petromyzon marinus	42.80	5.00e-88	318.00
IUUC-Pab-097793	Pongo abelii	100.00	0.00e+00	938.00
IUUC-Pca-100750	Procavia capensis	97.00	0.00e+00	913.00
IUUC-Pva-102505	Pteropus vampyrus	98.29	0.00e+00	955.00
IUUC-Rno-106051	Rattus norvegicus	91.65	0.00e+00	866.00
IUUC-Sar-113439	Sorex araneus	98.50	0.00e+00	927.00
IUUC-Ssc-115847	Sus scrofa	95.93	0.00e+00	889.00
IUUC-Tgu-117135	Taeniopygia guttata	86.94	0.00e+00	819.00
IUUC-Ttr-129088	Tursiops truncatus	98.93	0.00e+00	930.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence