iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000169918.9	ENST00000307050.5	ENSP00000305926.4
ENSG00000169918.9	ENST00000560536.5	ENSP00000453622.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/OTU	OTU	20622874; 12682062; 21139048
UBD/ZnF/ZnF_A20	ZnF_A20	23827681

Classification

Family	E-value	Score	Start	End
DUB/OTU	2.00e-40	140.0	200	374
UBD/ZnF/ZnF_A20	2.00e-15	58.0	885	919

Active Site

Position(s)	Description	Evidence
207	N/A	{ECO:0000250}
210	Nucleophile	ECO:0000250}
367	Proton acceptor	ECO:0000250}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek....edekefcqklvepe.....ak.g..... 77
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++++r+ +++++ k+++++++++++k    e+e++++ kl+++e     +k g     
   Q: 200  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYTMMRTGAEREALKRRWRWQQTQQNKeeewEREWTELLKLASSEprthfSKnGgtggg 291
           6899********************************************************999999************88777444377899 PP
   S: 78   ............eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
                       ee+h+f+La+iL+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++aLv++
   Q: 292  vdnsedpvyeslEEFHVFVLAHILRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPPNRcHCSPLVLAYDQAHFSALVSM 374
           ********************************************************************************986 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrrr 35
           p++++C++ +C+fYG++et++yCS+Cyreelrrrr
   Q: 885  PVQRRCQReNCAFYGRAETEHYCSYCYREELRRRR 919
           9********************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MVSSVLPNPT SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL 60
SDYEQLRQVH TANLPHVFNE GRGPKQPERE PQPGHKVERP CLQRQDDIAQ EKRLSRGISH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGGAGGGC GCGCGCCCGG AGGCAGCAGG CGGAGCCGGG AGGCGGGCGT TGTGCGCGGC 60
CGCGGGCGGA GCGGAGGGGC GCGAGGGGCG GAGCGGAGCG CGGGAGGAGG CGGGGGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response

KEGG

hsa:161725

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001551	Ailuropoda melanoleuca	97.62	0.00e+00	1028.00
IUUC-Apl-003825	Anas platyrhynchos	71.35	0.00e+00	1118.00
IUUC-Aca-004392	Anolis carolinensis	75.19	0.00e+00	1181.00
IUUC-Ame-011052	Astyanax mexicanus	70.72	0.00e+00	1102.00
IUUC-Bta-013296	Bos taurus	89.52	0.00e+00	1242.00
IUUC-Cja-019141	Callithrix jacchus	95.33	0.00e+00	1088.00
IUUC-Cfa-020447	Canis familiaris	96.33	0.00e+00	1112.00
IUUC-Cpo-022059	Cavia porcellus	95.33	0.00e+00	964.00
IUUC-Csa-023263	Chlorocebus sabaeus	98.67	0.00e+00	1136.00
IUUC-Cho-024611	Choloepus hoffmanni	84.97	2.00e-161	563.00
IUUC-Dre-028617	Danio rerio	68.14	0.00e+00	1091.00
IUUC-Dno-029121	Dasypus novemcinctus	90.70	0.00e+00	1032.00
IUUC-Ete-033068	Echinops telfairi	74.34	0.00e+00	1026.00
IUUC-Eca-034413	Equus caballus	97.13	0.00e+00	1066.00
IUUC-Fca-036487	Felis catus	91.64	0.00e+00	984.00
IUUC-Fal-037145	Ficedula albicollis	77.30	0.00e+00	1164.00
IUUC-Gmo-038786	Gadus morhua	64.03	0.00e+00	989.00
IUUC-Gga-040512	Gallus gallus	77.26	0.00e+00	1213.00
IUUC-Gac-041599	Gasterosteus aculeatus	70.16	0.00e+00	1079.00
IUUC-Ggo-044819	Gorilla gorilla	98.39	0.00e+00	1348.00
IUUC-Itr-047999	Ictidomys tridecemlineatus	89.39	0.00e+00	771.00
IUUC-Lch-050666	Latimeria chalumnae	73.67	0.00e+00	1127.00
IUUC-Loc-052841	Lepisosteus oculatus	71.00	0.00e+00	1134.00
IUUC-Laf-053437	Loxodonta africana	90.79	0.00e+00	1094.00
IUUC-Mcc-055353	Macaca mulatta	96.16	0.00e+00	1442.00
IUUC-Meu-056510	Macropus eugenii	73.29	9.00e-112	398.00
IUUC-Mga-059741	Meleagris gallopavo	75.41	0.00e+00	1174.00
IUUC-Mmr-061437	Microcebus murinus	94.21	0.00e+00	1417.00
IUUC-Mdo-061907	Monodelphis domestica	77.99	0.00e+00	1240.00
IUUC-Mmu-064074	Mus musculus	90.56	0.00e+00	1347.00
IUUC-Mpu-066004	Mustela putorius furo	94.59	0.00e+00	1000.00
IUUC-Nle-069182	Nomascus leucogenys	97.95	0.00e+00	1189.00
IUUC-Opr-070701	Ochotona princeps	88.38	0.00e+00	917.00
IUUC-Ont-072431	Oreochromis niloticus	86.86	0.00e+00	857.00
IUUC-Oan-073235	Ornithorhynchus anatinus	71.70	0.00e+00	1045.00
IUUC-Ocu-073935	Oryctolagus cuniculus	95.90	0.00e+00	1051.00
IUUC-Ola-087026	Oryzias latipes	67.52	0.00e+00	1083.00
IUUC-Oga-088249	Otolemur garnettii	95.73	0.00e+00	1122.00
IUUC-Oar-089476	Ovis aries	89.12	0.00e+00	1342.00
IUUC-Ptr-090548	Pan troglodytes	98.43	0.00e+00	1041.00
IUUC-Pan-092616	Papio anubis	93.45	0.00e+00	1350.00
IUUC-Psi-093126	Pelodiscus sinensis	77.42	0.00e+00	1193.00
IUUC-Pfo-096785	Poecilia formosa	65.56	0.00e+00	1049.00
IUUC-Pab-098336	Pongo abelii	96.48	0.00e+00	1271.00
IUUC-Pca-100206	Procavia capensis	83.67	0.00e+00	806.00
IUUC-Rno-105483	Rattus norvegicus	87.96	0.00e+00	981.00
IUUC-Sha-106617	Sarcophilus harrisii	87.02	0.00e+00	907.00
IUUC-Ssc-115415	Sus scrofa	86.86	0.00e+00	1144.00
IUUC-Tgu-117218	Taeniopygia guttata	85.67	0.00e+00	1038.00
IUUC-Tru-118720	Takifugu rubripes	87.92	0.00e+00	845.00
IUUC-Tni-120795	Tetraodon nigroviridis	80.09	0.00e+00	922.00
IUUC-Xtr-132158	Xenopus tropicalis	69.26	0.00e+00	1168.00
IUUC-Xma-133941	Xiphophorus maculatus	68.95	0.00e+00	1051.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence