iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170296.9	ENST00000302386.9	ENSP00000306866.5
ENSG00000170296.9	ENST00000570856.1	ENSP00000460489.1
ENSG00000170296.9	ENST00000573928.1	ENSP00000458476.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/ATG8	ATG8	11779480; 23721406

Classification

Family	E-value	Score	Start	End
ULD/UBL/ATG8	5.70e-53	179.1	13	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgf 92
           kr++e+ekir+k+pd++Pviveka+k++i++ldkkkylvPsdltvgq++++irkr++lraedalf++vnn+++++sat++++y+e+++ed+f
   Q: 13   KRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFF 104
           699***************************************************************************************** PP
   S: 93   lyvayaseetfG 104
           ly+ay++e+++G
   Q: 105  LYIAYSDESVYG 116
           ***********9 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Protein Sequence
(Fasta)

MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 60
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL 117

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGTTAACG AAAGGAACTT GGAGAACCAA GTCTCGTATG ATGATTACCA TCTTTTACTC 60
CTCTTCAGCC CCAGCTTCCT TGAGGGGACG GTTGGGGAAT AGGTTTAGAG TAATTTTCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0333--Golgi apparatus
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0044297--C:cell body
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0005764--C:lysosome
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005790--C:smooth endoplasmic reticulum
GO:0097225--C:sperm midpiece
GO:0048487--F:beta-tubulin binding
GO:0050811--F:GABA receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0097352--P:autophagosome maturation
GO:0007268--P:chemical synaptic transmission
GO:0008625--P:extrinsic apoptotic signaling pathway via death domain receptors
GO:0016236--P:macroautophagy
GO:0061024--P:membrane organization
GO:0000226--P:microtubule cytoskeleton organization
GO:0006605--P:protein targeting

KEGG

hsa:11337

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001323	Ailuropoda melanoleuca	100.00	4.00e-65	239.00
IUUC-Ago-007898	Ashbya gossypii	54.46	3.00e-34	136.00
IUUC-Acl-008314	Aspergillus clavatus	59.48	7.00e-39	152.00
IUUC-Afl-008708	Aspergillus flavus	59.48	9.00e-39	151.00
IUUC-Afu-009097	Aspergillus fumigatus	59.48	7.00e-39	152.00
IUUC-Ang-009530	Aspergillus niger	59.48	7.00e-39	152.00
IUUC-Aor-009909	Aspergillus oryzae	59.48	9.00e-39	151.00
IUUC-Ate-010358	Aspergillus terreus	59.48	7.00e-39	152.00
IUUC-Ame-010914	Astyanax mexicanus	98.28	6.00e-63	231.00
IUUC-Bgr-012248	Blumeria graminis	59.48	1.00e-38	151.00
IUUC-Bta-012805	Bos taurus	100.00	4.00e-65	239.00
IUUC-Bci-013959	Botrytis cinerea	60.34	3.00e-39	153.00
IUUC-Bra-016921	Brassica rapa	58.41	4.00e-39	152.00
IUUC-Cel-018200	Caenorhabditis elegans	83.62	1.00e-54	204.00
IUUC-Cja-019369	Callithrix jacchus	100.00	4.00e-65	239.00
IUUC-Cfa-020603	Canis familiaris	100.00	4.00e-65	239.00
IUUC-Csa-024117	Chlorocebus sabaeus	100.00	4.00e-65	239.00
IUUC-Cin-025297	Ciona intestinalis	92.24	2.00e-59	220.00
IUUC-Cgl-026691	Colletotrichum gloeosporioides	43.12	4.00e-32	130.00
IUUC-Cne-026889	Cryptococcus neoformans	58.04	3.00e-37	147.00
IUUC-Dre-028351	Danio rerio	99.14	1.00e-64	238.00
IUUC-Dno-029218	Dasypus novemcinctus	99.11	1.00e-61	230.00
IUUC-Dor-030245	Dipodomys ordii	100.00	4.00e-65	239.00
IUUC-Dse-031428	Dothistroma septosporum	59.48	7.00e-39	152.00
IUUC-Dme-031813	Drosophila melanogaster	91.45	2.00e-60	223.00
IUUC-Ete-032671	Echinops telfairi	98.29	2.00e-64	236.00
IUUC-Eeu-035131	Erinaceus europaeus	96.55	2.00e-45	172.00
IUUC-Fca-036493	Felis catus	100.00	6.00e-65	239.00
IUUC-Fox-037846	Fusarium oxysporum	59.48	8.00e-39	151.00
IUUC-Fso-038134	Fusarium solani	59.48	9.00e-39	151.00
IUUC-Gmo-039671	Gadus morhua	98.28	7.00e-63	232.00
IUUC-Gga-040257	Gallus gallus	96.55	1.00e-62	231.00
IUUC-Gac-042507	Gasterosteus aculeatus	98.28	3.00e-63	233.00
IUUC-Ggo-044860	Gorilla gorilla	100.00	6.00e-65	238.00
IUUC-Itr-048405	Ictidomys tridecemlineatus	100.00	4.00e-65	239.00
IUUC-Lch-049798	Latimeria chalumnae	77.59	1.00e-51	194.00
IUUC-Loc-052290	Lepisosteus oculatus	98.28	6.00e-63	232.00
IUUC-Laf-054203	Loxodonta africana	100.00	4.00e-65	239.00
IUUC-Mcc-055307	Macaca mulatta	100.00	4.00e-65	239.00
IUUC-Mla-059098	Melampsora laricipopulina	60.34	2.00e-39	154.00
IUUC-Mvi-060496	Microbotryum violaceum	59.82	7.00e-38	149.00
IUUC-Mmr-061776	Microcebus murinus	100.00	4.00e-65	239.00
IUUC-Mmu-064157	Mus musculus	100.00	4.00e-65	239.00
IUUC-Mpu-066028	Mustela putorius furo	100.00	4.00e-65	239.00
IUUC-Mlu-067166	Myotis lucifugus	100.00	4.00e-65	239.00
IUUC-Nfi-068367	Neosartorya fischeri	59.48	7.00e-39	152.00
IUUC-Ncr-068894	Neurospora crassa	59.48	8.00e-39	151.00
IUUC-Nle-069220	Nomascus leucogenys	100.00	4.00e-65	239.00
IUUC-Opr-070777	Ochotona princeps	100.00	5.00e-65	238.00
IUUC-Ocu-074148	Oryctolagus cuniculus	100.00	4.00e-65	239.00
IUUC-Ola-086391	Oryzias latipes	86.84	9.00e-52	194.00
IUUC-Olu-087892	Ostreococcus lucimarinus	63.48	3.00e-40	156.00
IUUC-Oga-088312	Otolemur garnettii	100.00	4.00e-65	239.00
IUUC-Oar-089989	Ovis aries	100.00	4.00e-65	239.00
IUUC-Ptr-091108	Pan troglodytes	100.00	4.00e-65	239.00
IUUC-Pno-095035	Phaeosphaeria nodorum	59.48	1.00e-38	151.00
IUUC-Ppa-095787	Physcomitrella patens	62.07	6.00e-40	155.00
IUUC-Pab-097660	Pongo abelii	100.00	4.00e-65	239.00
IUUC-Pca-100230	Procavia capensis	100.00	4.00e-65	239.00
IUUC-Pte-104230	Pyrenophora teres	59.48	1.00e-38	151.00
IUUC-Rno-105497	Rattus norvegicus	100.00	4.00e-65	239.00
IUUC-Sha-106656	Sarcophilus harrisii	100.00	4.00e-65	239.00
IUUC-Ssl-108578	Sclerotinia sclerotiorum	60.34	2.00e-39	153.00
IUUC-Sit-110531	Setaria italica	61.06	3.00e-39	153.00
IUUC-Sar-113670	Sorex araneus	92.31	9.00e-60	221.00
IUUC-Ssc-116182	Sus scrofa	100.00	4.00e-65	239.00
IUUC-Tru-118632	Takifugu rubripes	98.28	2.00e-63	234.00
IUUC-Tre-122077	Trichoderma reesei	59.48	6.00e-39	152.00
IUUC-Tvi-122400	Trichoderma virens	59.48	6.00e-39	152.00
IUUC-Vda-129807	Verticillium dahliae	59.48	7.00e-39	152.00
IUUC-Xma-133400	Xiphophorus maculatus	98.28	3.00e-63	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence