iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	8.30e-08	33.9	446	492

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplte 52
           +f C++ + l  +Pv++p+G+t+  +++e++l++  + cP+++ +l+e
   Q: 446  DFECALCMRLLFEPVTTPCGHTFCLKCLERCLDHAPH-CPLCKDKLSE 492
           79***********************************.******9976 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML AGLAQPDRGL 60
CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG GLVRAVGLRD RPLSAENPGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCCCCAGT CATTTAGGAC AATTTCCTAA GTCGAAGCTA GAGATGCGTG ATGCGTTTGG 60
TGACTTTTCC TGGGTTCTTG CTTAAGCGGA GCCACAGGTT GTGGGGGCGG CCAGGCCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51787--LON_N
PS50293--TPR_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02190--LON_substr_bdg
PF13445--zf-RING_UBOX

SMART

SM00464--LON
SM00184--RING
SM00028--TPR

Gene Ontology

GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

hsa:164832

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001867	Ailuropoda melanoleuca	87.31	0.00e+00	1026.00
IUUC-Apl-003355	Anas platyrhynchos	63.28	0.00e+00	676.00
IUUC-Aca-004822	Anolis carolinensis	56.44	0.00e+00	743.00
IUUC-Acl-008224	Aspergillus clavatus	31.96	1.00e-40	161.00
IUUC-Afu-008802	Aspergillus fumigatus	29.91	1.00e-37	151.00
IUUC-Ani-009473	Aspergillus nidulans	31.90	9.00e-42	165.00
IUUC-Ate-010489	Aspergillus terreus	33.85	1.00e-39	158.00
IUUC-Ame-010750	Astyanax mexicanus	49.35	0.00e+00	657.00
IUUC-Cja-019041	Callithrix jacchus	88.39	0.00e+00	1202.00
IUUC-Cfa-020025	Canis familiaris	86.33	0.00e+00	1030.00
IUUC-Cre-022730	Chlamydomonas reinhardtii	55.81	9.00e-09	53.90
IUUC-Csa-023324	Chlorocebus sabaeus	98.63	0.00e+00	1011.00
IUUC-Cin-025668	Ciona intestinalis	33.49	3.00e-94	339.00
IUUC-Cne-026875	Cryptococcus neoformans	28.57	4.00e-08	53.50
IUUC-Dre-028400	Danio rerio	51.59	3.00e-145	508.00
IUUC-Eeu-034779	Erinaceus europaeus	66.54	0.00e+00	639.00
IUUC-Fca-036276	Felis catus	87.36	0.00e+00	1030.00
IUUC-Fal-036669	Ficedula albicollis	61.12	0.00e+00	686.00
IUUC-Fso-038334	Fusarium solani	29.77	5.00e-41	162.00
IUUC-Gga-041253	Gallus gallus	59.03	0.00e+00	735.00
IUUC-Gma-042919	Glycine max	34.21	2.00e-38	153.00
IUUC-Ggo-045501	Gorilla gorilla	99.19	0.00e+00	1342.00
IUUC-Itr-048224	Ictidomys tridecemlineatus	81.42	0.00e+00	818.00
IUUC-Lch-049788	Latimeria chalumnae	49.73	0.00e+00	647.00
IUUC-Loc-051922	Lepisosteus oculatus	50.33	0.00e+00	639.00
IUUC-Laf-054421	Loxodonta africana	57.68	0.00e+00	770.00
IUUC-Mcc-054828	Macaca mulatta	98.04	0.00e+00	1006.00
IUUC-Meu-055901	Macropus eugenii	52.74	3.00e-174	605.00
IUUC-Mtr-058075	Medicago truncatula	36.96	3.00e-43	169.00
IUUC-Mga-059760	Meleagris gallopavo	61.63	0.00e+00	676.00
IUUC-Mmr-061350	Microcebus murinus	80.03	0.00e+00	936.00
IUUC-Mdo-062203	Monodelphis domestica	58.63	0.00e+00	792.00
IUUC-Mmu-064118	Mus musculus	78.81	0.00e+00	787.00
IUUC-Mpu-065764	Mustela putorius furo	84.84	0.00e+00	1112.00
IUUC-Nfi-068337	Neosartorya fischeri	31.65	5.00e-38	152.00
IUUC-Nle-069616	Nomascus leucogenys	98.92	0.00e+00	1345.00
IUUC-Ont-072142	Oreochromis niloticus	48.47	0.00e+00	659.00
IUUC-Oga-088972	Otolemur garnettii	87.18	0.00e+00	1177.00
IUUC-Ptr-090992	Pan troglodytes	99.48	0.00e+00	1120.00
IUUC-Pan-092180	Papio anubis	96.63	0.00e+00	1308.00
IUUC-Psi-093423	Pelodiscus sinensis	62.89	0.00e+00	669.00
IUUC-Pfo-096363	Poecilia formosa	50.00	0.00e+00	644.00
IUUC-Pab-097974	Pongo abelii	98.11	0.00e+00	1330.00
IUUC-Pop-100044	Populus trichocarpa	36.94	4.00e-43	169.00
IUUC-Pva-102269	Pteropus vampyrus	79.09	0.00e+00	1076.00
IUUC-Pgr-103289	Puccinia graminis	26.78	1.00e-26	114.00
IUUC-Rno-105905	Rattus norvegicus	80.04	0.00e+00	818.00
IUUC-Ssc-116224	Sus scrofa	72.09	7.00e-180	624.00
IUUC-Tgu-117000	Taeniopygia guttata	61.13	0.00e+00	706.00
IUUC-Tru-118016	Takifugu rubripes	48.38	1.00e-179	623.00
IUUC-Tni-119913	Tetraodon nigroviridis	47.79	1.00e-163	570.00
IUUC-Ttr-128666	Tursiops truncatus	78.89	0.00e+00	1065.00
IUUC-Uma-129541	Ustilago maydis	33.98	2.00e-33	138.00
IUUC-Vpa-130334	Vicugna pacos	65.23	3.00e-173	601.00
IUUC-Vvi-130910	Vitis vinifera	33.64	3.00e-39	156.00
IUUC-Xtr-132065	Xenopus tropicalis	50.33	0.00e+00	684.00
IUUC-Xma-134324	Xiphophorus maculatus	50.00	0.00e+00	651.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence