iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000008513.2	ENSPPYT00000033463.1	ENSPPYP00000024201.1
ENSPPYG00000008513.2	ENSPPYT00000009946.1	ENSPPYP00000009565.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.90e-107	357.2	732	1565

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtC+mNS +Qc sn+++l++++ + ++  +ln++np ++kg+++k++ +l++elw++++k+v+p +l  +++k+a++f+g
   Q: 732  TGLSNLGNTCFMNSSIQCVSNTQPLTQYFISgRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNG 818
           7******************************9******************************************************* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           ++qqD+qE+laflld+l+e+l++ ++kp+ e++++d +  +++     a++++ ++n+s+++dlF+gql+sq+kc++c+++s+r++p
   Q: 819  FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGR--PNWevaaeAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDP 903
           ********************************999943..33344566*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           f+ lslp+p+++ +++e                                                                      
   Q: 904  FNFLSLPLPMDSYMHLEitvirldgttpvryglrlnmdekytglkkqlsdlcglnseqillaevhgsniknfpqdnqkvrlsvsgfl 990
           *************9999********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 991  cafeipvpaspisassptqtdfssspstngmftlttngdlprpifipngmpntvvpcgteknftngmvnghmpslpdspftgyiiav 1077
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1078 hrkmmrtelyflssqknrpslfgmplivpctvhtrkkdlydavwiqvsrlasplppqeasnhaqdcddsmgyqypftlrvvqkdgns 1164
           *************************************************************************************** PP
   S: 186  ...................................................................slqdcLesftkeeelegenk 205
                                                                              +l++cL++ft+eeel ++++
   Q: 1165 cawcpwyrfcrgckidcgedrafignayiavdwdptalhlryqtsqervvdehesveqsrraqaepiNLDSCLRAFTSEEELGENEM 1251
           *************************************************************************************** PP
   S: 206  yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts........................ 267
           yyc+kck ++ a+kkl+l++lP++Li+hLkRf+f +   + +k +k v+fp+e +d s f++                         
   Q: 1252 YYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNG--RWIKSQKIVKFPREsFDPSAFLVPrdpalcqrkpltpqgdelsepril 1336
           ********************************99775..5569******************99999999999999999999999999 PP
   S: 268  ....................................................................................... 267
                                                                                                  
   Q: 1337 arelkkvdaqssageedvllskspsslsaniisspkgspsssrksgtscpssknsspnssprtlgrskgrlrlpqigsknklssske 1423
           999999999999998888888888888888888888888888888887777777766666666666666666666666665555555 PP
   S: 268  ..peekqke.............................................................................k 275
             +                                                                                   k
   Q: 1424 nlD-----AskengagqiceladalsrghvlggsqpelvtpqdhevalangflyeheacgngysngqlgnhseedstddqredtriK 1505
           550.....055555555555555666666666666666666666666666666666666666666666666666667777788888* PP
   S: 276  kkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
            +Y+L+a+ +HsG l++GHYv+y+kn + kW++++Ds+++e++ +e+ +   ++aY+lfY+++
   Q: 1506 PIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDT---DSAYILFYEQQ 1565
           *************************************************...********985 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

CGGRWGRGTP TPSPSPRDAE EKAGGGWGDQ APTPGRGDEG SMGAKESRIG FLSYEEALRR 60
VIYCSFGGTS KGLHFNNLIV GLVLLTRGKD EEKAKYIFSL FSSESGNYVI REEMERMLHV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGGGGGGA GGTGGGGGCG GGGGACGCCG ACACCGTCAC CGTCACCCAG GGACGCCGAG 60
GAGAAGGCGG GAGGGGGGTG GGGGTGAGAT CAGGCTCCGA CCCCCGGCCG AGGGGATGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF13202--EF-hand_5
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP
SM00054--EFh

Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005509--F:calcium ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001611	Ailuropoda melanoleuca	96.57	0.00e+00	2615.00
IUUC-Apl-003272	Anas platyrhynchos	83.33	0.00e+00	2610.00
IUUC-Aca-005057	Anolis carolinensis	83.37	0.00e+00	2219.00
IUUC-Ame-010781	Astyanax mexicanus	71.96	0.00e+00	2304.00
IUUC-Bta-013502	Bos taurus	92.61	0.00e+00	2815.00
IUUC-Cja-018754	Callithrix jacchus	95.64	0.00e+00	3019.00
IUUC-Cfa-020526	Canis familiaris	96.76	0.00e+00	2955.00
IUUC-Cpo-021568	Cavia porcellus	91.27	0.00e+00	2763.00
IUUC-Csa-023143	Chlorocebus sabaeus	95.89	0.00e+00	2991.00
IUUC-Cho-024603	Choloepus hoffmanni	63.81	3.00e-173	603.00
IUUC-Cin-025583	Ciona intestinalis	49.03	0.00e+00	1207.00
IUUC-Csv-026344	Ciona savignyi	45.50	0.00e+00	1109.00
IUUC-Dre-028121	Danio rerio	73.54	0.00e+00	2272.00
IUUC-Dno-029911	Dasypus novemcinctus	94.96	0.00e+00	2922.00
IUUC-Dor-030608	Dipodomys ordii	60.26	0.00e+00	1131.00
IUUC-Dme-032094	Drosophila melanogaster	45.02	1.00e-122	434.00
IUUC-Ete-032639	Echinops telfairi	93.26	0.00e+00	1574.00
IUUC-Eca-034253	Equus caballus	96.50	0.00e+00	2967.00
IUUC-Eeu-035084	Erinaceus europaeus	80.04	0.00e+00	1569.00
IUUC-Fca-035474	Felis catus	96.27	0.00e+00	2501.00
IUUC-Fal-036985	Ficedula albicollis	84.28	0.00e+00	2564.00
IUUC-Gmo-039568	Gadus morhua	77.65	0.00e+00	2031.00
IUUC-Gga-040509	Gallus gallus	80.78	0.00e+00	2632.00
IUUC-Gac-041757	Gasterosteus aculeatus	77.53	0.00e+00	2080.00
IUUC-Ggo-044956	Gorilla gorilla	85.89	0.00e+00	1756.00
IUUC-Hsa-046107	Homo sapiens	96.51	0.00e+00	3026.00
IUUC-Itr-048865	Ictidomys tridecemlineatus	95.93	0.00e+00	1198.00
IUUC-Lch-050681	Latimeria chalumnae	77.78	0.00e+00	2363.00
IUUC-Loc-052474	Lepisosteus oculatus	75.60	0.00e+00	2381.00
IUUC-Laf-054273	Loxodonta africana	93.02	0.00e+00	2937.00
IUUC-Mcc-054718	Macaca mulatta	95.95	0.00e+00	3018.00
IUUC-Meu-056558	Macropus eugenii	73.64	0.00e+00	1314.00
IUUC-Mga-059892	Meleagris gallopavo	84.79	0.00e+00	2653.00
IUUC-Mmr-060866	Microcebus murinus	94.12	0.00e+00	3016.00
IUUC-Mdo-062607	Monodelphis domestica	89.66	0.00e+00	2868.00
IUUC-Mmu-063797	Mus musculus	92.89	0.00e+00	2990.00
IUUC-Mpu-066121	Mustela putorius furo	94.39	0.00e+00	2991.00
IUUC-Mlu-067581	Myotis lucifugus	94.71	0.00e+00	2949.00
IUUC-Nle-069916	Nomascus leucogenys	96.37	0.00e+00	2904.00
IUUC-Opr-071073	Ochotona princeps	84.19	0.00e+00	1115.00
IUUC-Ont-071310	Oreochromis niloticus	78.09	0.00e+00	2053.00
IUUC-Oan-073356	Ornithorhynchus anatinus	90.10	0.00e+00	2776.00
IUUC-Ocu-074216	Oryctolagus cuniculus	93.70	0.00e+00	2960.00
IUUC-Ola-087434	Oryzias latipes	80.45	0.00e+00	2007.00
IUUC-Oga-089034	Otolemur garnettii	96.83	0.00e+00	2986.00
IUUC-Oar-090369	Ovis aries	96.57	0.00e+00	2991.00
IUUC-Ptr-090605	Pan troglodytes	96.57	0.00e+00	3030.00
IUUC-Pan-092381	Papio anubis	98.58	0.00e+00	3000.00
IUUC-Psi-093819	Pelodiscus sinensis	86.96	0.00e+00	2708.00
IUUC-Pma-094480	Petromyzon marinus	63.44	0.00e+00	1406.00
IUUC-Pfo-096561	Poecilia formosa	76.80	0.00e+00	2013.00
IUUC-Pca-100944	Procavia capensis	77.99	0.00e+00	1027.00
IUUC-Pva-102732	Pteropus vampyrus	83.94	0.00e+00	2609.00
IUUC-Rno-105113	Rattus norvegicus	95.33	0.00e+00	2946.00
IUUC-Sha-107608	Sarcophilus harrisii	84.40	2.00e-172	598.00
IUUC-Sar-113201	Sorex araneus	83.99	0.00e+00	1692.00
IUUC-Ssc-115469	Sus scrofa	94.60	0.00e+00	659.00
IUUC-Tgu-117322	Taeniopygia guttata	81.95	0.00e+00	2645.00
IUUC-Tru-118705	Takifugu rubripes	68.04	0.00e+00	667.00
IUUC-Tsy-119433	Tarsius syrichta	81.45	0.00e+00	2115.00
IUUC-Tni-120631	Tetraodon nigroviridis	80.11	0.00e+00	2051.00
IUUC-Tbe-127553	Tupaia belangeri	88.02	0.00e+00	703.00
IUUC-Ttr-128260	Tursiops truncatus	95.66	0.00e+00	2954.00
IUUC-Vpa-130479	Vicugna pacos	91.38	0.00e+00	2754.00
IUUC-Xtr-132686	Xenopus tropicalis	83.05	0.00e+00	2517.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence