iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	21199876; 11384984

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.70e-15	57.6	230	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 7    lrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           l  ep +L++LCR+++r +lg++rl +i++LPLP sLk YLly+
   Q: 230  LDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ 273
           5679***************************************8 PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND 60
RSLNVFVKED DKLIFHRHPV AQSTDAIRGK VGYTRGLHVW QITWAMRQRG THAVVGVATA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTTTTCTC CTCCGCACAG AAGTCGCGCT CGGGCAGCCT GCGCGCTCGC AGCAGGAACC 60
AGGCTCCAGG CGCCGGCGCC GGGGCCGGGG CCGCGGGGAG GAGGCGACTT CGCTCCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50225--SOCS

Pfam

PF07525--SOCS_box
PF00622--SPRY

SMART

SM00969--SOCS_box
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
GO:0000209--P:protein polyubiquitination

KEGG

hsa:80176

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002040	Ailuropoda melanoleuca	97.80	1.00e-159	555.00
IUUC-Apl-004008	Anas platyrhynchos	95.97	2.00e-156	544.00
IUUC-Aca-004631	Anolis carolinensis	91.58	2.00e-151	528.00
IUUC-Aly-006295	Arabidopsis lyrata	24.27	1.70e-01	31.20
IUUC-Ame-010841	Astyanax mexicanus	86.45	1.00e-144	504.00
IUUC-Bta-012816	Bos taurus	98.53	9.00e-161	558.00
IUUC-Cja-019531	Callithrix jacchus	99.63	3.00e-162	563.00
IUUC-Cfa-020107	Canis familiaris	98.90	1.00e-161	561.00
IUUC-Cpo-021983	Cavia porcellus	98.53	6.00e-160	556.00
IUUC-Csa-023603	Chlorocebus sabaeus	99.27	4.00e-162	563.00
IUUC-Cin-025737	Ciona intestinalis	60.48	8.00e-94	337.00
IUUC-Csv-026238	Ciona savignyi	58.80	3.00e-90	324.00
IUUC-Dre-028699	Danio rerio	87.18	2.00e-145	508.00
IUUC-Dno-028959	Dasypus novemcinctus	98.84	2.00e-153	535.00
IUUC-Dor-030400	Dipodomys ordii	98.17	1.00e-159	555.00
IUUC-Dme-031730	Drosophila melanogaster	70.40	5.00e-116	410.00
IUUC-Eca-034017	Equus caballus	99.27	9.00e-162	562.00
IUUC-Eeu-035331	Erinaceus europaeus	97.44	2.00e-158	551.00
IUUC-Fca-035981	Felis catus	98.90	1.00e-161	561.00
IUUC-Fal-037253	Ficedula albicollis	92.31	2.00e-151	528.00
IUUC-Fox-037964	Fusarium oxysporum	34.48	1.00e-02	35.40
IUUC-Gmo-038813	Gadus morhua	78.75	2.00e-132	464.00
IUUC-Gga-040286	Gallus gallus	95.60	3.00e-155	540.00
IUUC-Gac-041392	Gasterosteus aculeatus	81.68	3.00e-137	481.00
IUUC-Ggo-044990	Gorilla gorilla	99.63	3.00e-162	563.00
IUUC-Itr-048565	Ictidomys tridecemlineatus	99.60	1.00e-150	525.00
IUUC-Lch-049583	Latimeria chalumnae	87.91	6.00e-140	489.00
IUUC-Loc-052220	Lepisosteus oculatus	86.45	2.00e-143	501.00
IUUC-Laf-053976	Loxodonta africana	98.44	5.00e-151	526.00
IUUC-Mcc-055223	Macaca mulatta	99.63	3.00e-162	563.00
IUUC-Meu-056426	Macropus eugenii	98.53	2.00e-160	558.00
IUUC-Mga-059620	Meleagris gallopavo	95.60	3.00e-155	540.00
IUUC-Mmr-061373	Microcebus murinus	98.17	6.00e-160	556.00
IUUC-Mdo-063064	Monodelphis domestica	98.17	6.00e-160	556.00
IUUC-Mmu-064370	Mus musculus	98.53	6.00e-160	556.00
IUUC-Mpu-066516	Mustela putorius furo	98.53	7.00e-161	559.00
IUUC-Opr-070732	Ochotona princeps	97.07	9.00e-158	549.00
IUUC-Ont-071692	Oreochromis niloticus	81.68	6.00e-137	479.00
IUUC-Oan-072793	Ornithorhynchus anatinus	92.09	2.00e-137	481.00
IUUC-Ocu-074726	Oryctolagus cuniculus	97.44	9.00e-158	548.00
IUUC-Ogl-077661	Oryza glaberrima	50.00	7.00e-03	31.60
IUUC-Ola-086593	Oryzias latipes	81.32	3.00e-135	474.00
IUUC-Oga-089174	Otolemur garnettii	98.90	6.00e-161	559.00
IUUC-Oar-089518	Ovis aries	98.90	7.00e-161	559.00
IUUC-Ptr-090932	Pan troglodytes	99.63	3.00e-162	563.00
IUUC-Pan-091876	Papio anubis	99.63	3.00e-162	563.00
IUUC-Psi-093032	Pelodiscus sinensis	96.34	1.00e-157	548.00
IUUC-Pfo-096274	Poecilia formosa	80.95	2.00e-135	474.00
IUUC-Pab-097701	Pongo abelii	100.00	2.00e-137	481.00
IUUC-Pca-100140	Procavia capensis	96.10	2.00e-133	467.00
IUUC-Pva-102977	Pteropus vampyrus	99.63	3.00e-162	563.00
IUUC-Rno-105030	Rattus norvegicus	98.17	1.00e-159	555.00
IUUC-Sha-107161	Sarcophilus harrisii	93.04	1.00e-149	522.00
IUUC-Tgu-116619	Taeniopygia guttata	94.51	1.00e-152	532.00
IUUC-Tru-118256	Takifugu rubripes	80.95	9.00e-136	476.00
IUUC-Tni-120305	Tetraodon nigroviridis	82.05	6.00e-136	476.00
IUUC-Tbe-127668	Tupaia belangeri	100.00	2.00e-137	481.00
IUUC-Xtr-132803	Xenopus tropicalis	89.74	6.00e-150	523.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence