iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046878

UUCD1 version

UUC-HoS-00849

Ensembl Protein ID

ENSP00000315454.4

UniProt Accession

Q12830; Q6NX67; Q7Z7D6; Q9UIG2; BPTF_HUMAN

Genbank Protein ID

BAA89208.1; AAA97522.1; AAP22284.1; AAH67234.1

Protein Name

Nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen

Genbank Nucleotide ID

AB032251; AC006534; AY282495; BC067234

Gene Name

BPTF; FAC1; FALZ

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000171634.16	ENST00000544778.6	ENSP00000440854.2
ENSG00000171634.16	ENST00000306378.10	ENSP00000307208.6
ENSG00000171634.16	ENST00000424123.7	ENSP00000388405.3
ENSG00000171634.16	ENST00000544491.2	ENSP00000443949.2
ENSG00000171634.16	ENST00000582467.1	ENSP00000463776.1
ENSG00000171634.16	ENST00000580465.5	ENSP00000462535.1
ENSG00000171634.16	ENST00000342579.7	ENSP00000343837.3
ENSG00000171634.16	ENST00000581258.5	ENSP00000463845.1
ENSG00000171634.16	ENST00000583990.1	ENSP00000463736.1
ENSG00000171634.16	ENST00000577837.1	ENSP00000462703.1
ENSG00000171634.16	ENST00000335221.9	ENSP00000334351.6
ENSG00000171634.16	ENST00000321892.8	ENSP00000315454.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.10e-14	55.1	2869	2917

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           +C +C+ +++++k  + C++C++w+H +C+++  ++e +  +++ Cp+C+s
   Q: 2869 YC-ICKTPYDESKFYIGCDRCQNWYHGRCVGIL-QSEAELIDEYVCPQCQS 2917
           8*.*****************************9.888888888******87 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with MAZ. Interacts with KEAP1. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with histone H3K4me3 and to a lesser extent with histone H3-K4Me2.

Protein Sequence
(Fasta)

MRGRRGRPPK QPAAPAAERC APAPPPPPPP PTSGPIGGLR SRHRGSSRGR WAAAQAEVAP 60
KTRLSSPRGG SSSRRKPPPP PPAPPSTSAP GRGGRGGGGG RTGGGGGGGH LARTTAARRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAAGATG GCGGCTGAAG GCGATCCGGA GTGGGGCCCC AGCAATTCGG ATTGAGCCTT 60
CTCCCTCCAC CCGCTTCCGT CGGCCGGGCC CCTCCCGCCC GGCCCCGCGG GCCTCCCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00439--Bromodomain
PF02791--DDT
PF00628--PHD
PF15612--WHIM1
PF15613--WSD

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00571--DDT
SM00249--PHD

Gene Ontology

GO:0044297--C:cell body
GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016589--C:NURF complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0043565--F:sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0007420--P:brain development
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:0006338--P:chromatin remodeling
GO:0016569--P:covalent chromatin modification
GO:0001892--P:embryonic placenta development
GO:0007492--P:endoderm development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009611--P:response to wounding
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:2186

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000221	Aegilops tauschii	29.34	9.00e-12	67.00
IUUC-Aml-001431	Ailuropoda melanoleuca	91.16	0.00e+00	3679.00
IUUC-Apl-003251	Anas platyrhynchos	65.21	0.00e+00	1443.00
IUUC-Aca-005148	Anolis carolinensis	71.62	0.00e+00	742.00
IUUC-Ame-011093	Astyanax mexicanus	65.70	4.00e-152	534.00
IUUC-Bta-012701	Bos taurus	89.34	0.00e+00	3455.00
IUUC-Bol-015269	Brassica oleracea	27.80	1.00e-18	90.10
IUUC-Bra-018092	Brassica rapa	27.34	4.00e-18	88.20
IUUC-Cel-018283	Caenorhabditis elegans	34.32	3.00e-54	208.00
IUUC-Cja-018809	Callithrix jacchus	95.96	0.00e+00	779.00
IUUC-Cfa-021079	Canis familiaris	91.38	0.00e+00	4129.00
IUUC-Cpo-021892	Cavia porcellus	84.96	0.00e+00	2120.00
IUUC-Csa-023142	Chlorocebus sabaeus	94.90	0.00e+00	3750.00
IUUC-Cho-024758	Choloepus hoffmanni	78.93	0.00e+00	1228.00
IUUC-Cin-025225	Ciona intestinalis	52.85	1.00e-41	165.00
IUUC-Csv-026235	Ciona savignyi	50.29	4.00e-56	211.00
IUUC-Dre-028054	Danio rerio	76.25	1.00e-175	612.00
IUUC-Dno-029508	Dasypus novemcinctus	80.73	0.00e+00	1856.00
IUUC-Dor-030950	Dipodomys ordii	71.57	0.00e+00	874.00
IUUC-Dme-032140	Drosophila melanogaster	52.21	1.00e-104	375.00
IUUC-Ete-032789	Echinops telfairi	77.64	0.00e+00	2041.00
IUUC-Eca-033972	Equus caballus	89.86	0.00e+00	3435.00
IUUC-Eeu-034541	Erinaceus europaeus	75.64	0.00e+00	1228.00
IUUC-Fca-036272	Felis catus	89.63	0.00e+00	2705.00
IUUC-Fal-037141	Ficedula albicollis	68.02	0.00e+00	2228.00
IUUC-Gmo-039453	Gadus morhua	77.99	2.00e-172	601.00
IUUC-Gga-040833	Gallus gallus	63.34	0.00e+00	2264.00
IUUC-Gac-042513	Gasterosteus aculeatus	74.69	0.00e+00	671.00
IUUC-Ggo-045377	Gorilla gorilla	95.82	0.00e+00	1361.00
IUUC-Hvu-047760	Hordeum vulgare	25.46	1.00e-17	86.30
IUUC-Itr-048740	Ictidomys tridecemlineatus	85.80	0.00e+00	2242.00
IUUC-Lch-049744	Latimeria chalumnae	60.29	0.00e+00	1988.00
IUUC-Loc-052694	Lepisosteus oculatus	51.31	0.00e+00	1223.00
IUUC-Laf-054223	Loxodonta africana	89.50	0.00e+00	3299.00
IUUC-Mcc-054601	Macaca mulatta	97.37	0.00e+00	4347.00
IUUC-Mtr-058758	Medicago truncatula	26.54	3.00e-22	101.00
IUUC-Mga-060204	Meleagris gallopavo	63.69	0.00e+00	2053.00
IUUC-Mmr-061332	Microcebus murinus	90.79	0.00e+00	2464.00
IUUC-Mdo-062245	Monodelphis domestica	72.00	0.00e+00	2669.00
IUUC-Mmu-063744	Mus musculus	78.99	0.00e+00	3578.00
IUUC-Mac-065252	Musa acuminata	24.82	1.00e-18	90.10
IUUC-Mpu-066289	Mustela putorius furo	88.25	0.00e+00	3390.00
IUUC-Mlu-066991	Myotis lucifugus	89.74	0.00e+00	3409.00
IUUC-Nle-070095	Nomascus leucogenys	97.81	0.00e+00	3734.00
IUUC-Ont-071778	Oreochromis niloticus	79.89	0.00e+00	665.00
IUUC-Oan-073261	Ornithorhynchus anatinus	68.91	0.00e+00	2478.00
IUUC-Ocu-074848	Oryctolagus cuniculus	87.33	0.00e+00	4025.00
IUUC-Ogu-078676	Oryza glumaepatula	22.53	1.00e-18	89.70
IUUC-Olo-080881	Oryza longistaminata	26.25	1.00e-16	83.20
IUUC-Ome-081742	Oryza meridionalis	26.10	4.00e-17	85.10
IUUC-Oru-084745	Oryza rufipogon	22.53	1.00e-18	90.10
IUUC-Ola-086685	Oryzias latipes	76.06	0.00e+00	645.00
IUUC-Oga-088994	Otolemur garnettii	90.42	0.00e+00	3403.00
IUUC-Oar-090271	Ovis aries	89.52	0.00e+00	3415.00
IUUC-Ptr-090821	Pan troglodytes	99.09	0.00e+00	4477.00
IUUC-Pan-092346	Papio anubis	86.85	1.00e-134	474.00
IUUC-Psi-093425	Pelodiscus sinensis	68.00	0.00e+00	2598.00
IUUC-Pma-094355	Petromyzon marinus	63.32	3.00e-153	537.00
IUUC-Pno-094853	Phaeosphaeria nodorum	41.10	2.00e-16	81.30
IUUC-Pfo-096995	Poecilia formosa	78.17	0.00e+00	631.00
IUUC-Pab-098056	Pongo abelii	96.34	0.00e+00	3772.00
IUUC-Pop-099219	Populus trichocarpa	29.17	4.00e-15	78.20
IUUC-Pca-100922	Procavia capensis	83.61	0.00e+00	2288.00
IUUC-Pva-103167	Pteropus vampyrus	87.67	0.00e+00	2333.00
IUUC-Pgr-103292	Puccinia graminis	51.79	8.00e-15	75.10
IUUC-Ptt-104009	Puccinia triticina	42.50	1.00e-16	80.90
IUUC-Rno-105749	Rattus norvegicus	76.94	0.00e+00	2897.00
IUUC-Sha-106874	Sarcophilus harrisii	72.02	0.00e+00	2575.00
IUUC-Sly-111813	Solanum lycopersicum	28.22	2.00e-12	68.90
IUUC-Stu-111932	Solanum tuberosum	50.00	4.00e-10	58.50
IUUC-Sar-113725	Sorex araneus	85.13	0.00e+00	813.00
IUUC-Tgu-117339	Taeniopygia guttata	94.97	2.00e-110	394.00
IUUC-Tru-118620	Takifugu rubripes	78.84	0.00e+00	631.00
IUUC-Tni-120313	Tetraodon nigroviridis	55.02	0.00e+00	1043.00
IUUC-Tbe-127684	Tupaia belangeri	82.46	0.00e+00	1635.00
IUUC-Ttr-128434	Tursiops truncatus	81.86	0.00e+00	2268.00
IUUC-Vpa-130338	Vicugna pacos	83.92	0.00e+00	1195.00
IUUC-Xtr-132434	Xenopus tropicalis	58.83	0.00e+00	1162.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence