iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004267

UUCD1 version

UUC-AnC-00985

Ensembl Protein ID

ENSACAP00000013100.3

UniProt Accession

G1KNL4; G1KNL4_ANOCA

Protein Name

Uncharacterized protein

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000013261.3	ENSACAT00000013360.3	ENSACAP00000013100.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.90e-116	387.3	565	1306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ ++++++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 565  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFESEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 651
           7******************************99****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a+ ++k++n+s+i+dlFqgq+ks+++c+ c +vs +++p
   Q: 652  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWHRHKMRNDSFIVDLFQGQYKSKLVCPVCSKVSITFDP 736
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 737  FLYLPVPLPQKQKVLTVyyfakephkkpvkflvsiskenstamevldsvshsvrvnpenlrlaeviknrfhrmflpshsldavspsd 823
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 824  lllcfevlspdlakervvelqvqqrpqvpsvpitkcaacqkkqqseeeklkrctrcyrvgycnvvcqrthwsdhktlcrpenigfpf 910
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 911  lisvpesrltyarlaqllegyarysvsvfqppfqvgrmspeqglqhpekqepsarnssatasaasdststlesgdgaraphllsepq 997
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 998  asfsgpelqpelgdvsvvrskitpgrssglnldsgmsetlvtsrtetcmelpfmelprtskpeaaipgyqhsaeglsshvtqfyink 1084
           *************************************************************************************** PP
   S: 186  .................................................................slqdcLesftkeeelegenkyy 207
                                                                            +l++cL+ ftk+e l  e+++y
   Q: 1085 idasskeqkledkgdipldltddcslalvwknnermkefvlveskdlecvedpgsaseaaraghfTLEQCLNLFTKPEVLAPEEAWY 1171
           *************************************************************************************** PP
   S: 208  cekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssG 293
           c+kck+++ea+k+l+l++lP+vLi++LkRfsf++  +++ kin+ v+fp + Ldls+fc+ ++++q +   Y+L+av++H+G++ +G
   Q: 1172 CPKCKQHREASKQLMLWRLPNVLIIQLKRFSFRSFIWRD-KINDMVDFPVRsLDLSKFCIGQKDEQ-QLPMYDLYAVINHYGGMIGG 1256
           ***********************************8886.*********************88877.5******************* PP
   S: 294  HYvayvknekgk........WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           HY+ay++  ++k        W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1257 HYTAYARLPSDKnsqrsdvgWRLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1306
           *******9444444567788*******************...********996 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSSSASVPGQ RRTARGADDA TNKKKQKDRA NQESKEGERP VGSDSKKDLL LDWKQNADEV 60
IIKLSLGGGI PKTEEVDASF TDTSCFIRLP GGRQWSCQFY EEIESSCSKV QYKKGNILQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCATTTTGTT CATTGCCAGA GAGATTGATC ACAAAGAGTC GCCAAGATAG CTGGCTCGGG 60
AAGAAAACGT CGCACCCCTG ACCCAGACTC CGTCACTGAC CCCGGCGGGC CGTTTGTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	75.82	0.00e+00	1573.00
IUUC-Apl-003368	Anas platyrhynchos	77.42	0.00e+00	1904.00
IUUC-Ame-010970	Astyanax mexicanus	72.52	0.00e+00	1402.00
IUUC-Bta-012905	Bos taurus	75.80	0.00e+00	1552.00
IUUC-Cel-018257	Caenorhabditis elegans	45.36	6.00e-91	328.00
IUUC-Cja-018789	Callithrix jacchus	77.54	0.00e+00	1531.00
IUUC-Cfa-021004	Canis familiaris	75.89	0.00e+00	1550.00
IUUC-Cpo-021529	Cavia porcellus	67.15	0.00e+00	1658.00
IUUC-Csa-024035	Chlorocebus sabaeus	76.25	0.00e+00	1583.00
IUUC-Cho-025036	Choloepus hoffmanni	76.89	0.00e+00	687.00
IUUC-Cin-025451	Ciona intestinalis	42.12	2.00e-84	307.00
IUUC-Dre-028556	Danio rerio	71.33	0.00e+00	1375.00
IUUC-Dno-029240	Dasypus novemcinctus	74.65	0.00e+00	1427.00
IUUC-Dor-030495	Dipodomys ordii	75.48	0.00e+00	952.00
IUUC-Ete-032741	Echinops telfairi	77.02	0.00e+00	1488.00
IUUC-Eca-033661	Equus caballus	78.51	0.00e+00	1535.00
IUUC-Eeu-034648	Erinaceus europaeus	85.09	0.00e+00	647.00
IUUC-Fca-035646	Felis catus	76.18	0.00e+00	1545.00
IUUC-Fal-037094	Ficedula albicollis	83.96	0.00e+00	1738.00
IUUC-Gmo-038869	Gadus morhua	73.11	0.00e+00	867.00
IUUC-Gga-041170	Gallus gallus	75.38	0.00e+00	1937.00
IUUC-Gac-041901	Gasterosteus aculeatus	69.51	0.00e+00	1348.00
IUUC-Ggo-044708	Gorilla gorilla	77.44	0.00e+00	1523.00
IUUC-Hsa-046791	Homo sapiens	77.65	0.00e+00	1524.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	64.97	0.00e+00	1587.00
IUUC-Lch-050456	Latimeria chalumnae	70.34	0.00e+00	1174.00
IUUC-Loc-052861	Lepisosteus oculatus	60.70	0.00e+00	1217.00
IUUC-Laf-053788	Loxodonta africana	78.08	0.00e+00	1501.00
IUUC-Mcc-055693	Macaca mulatta	66.44	0.00e+00	1649.00
IUUC-Meu-055921	Macropus eugenii	79.77	0.00e+00	1345.00
IUUC-Mga-059879	Meleagris gallopavo	75.78	0.00e+00	1874.00
IUUC-Mmr-060802	Microcebus murinus	67.86	0.00e+00	1633.00
IUUC-Mdo-061856	Monodelphis domestica	79.28	0.00e+00	1520.00
IUUC-Mmu-063874	Mus musculus	67.56	0.00e+00	1694.00
IUUC-Mpu-066166	Mustela putorius furo	76.18	0.00e+00	1549.00
IUUC-Nle-070161	Nomascus leucogenys	67.60	0.00e+00	1639.00
IUUC-Opr-071015	Ochotona princeps	77.35	0.00e+00	1508.00
IUUC-Ont-072308	Oreochromis niloticus	71.01	0.00e+00	1433.00
IUUC-Oan-072723	Ornithorhynchus anatinus	77.10	0.00e+00	1526.00
IUUC-Ocu-073938	Oryctolagus cuniculus	76.44	0.00e+00	1546.00
IUUC-Ola-086375	Oryzias latipes	70.35	0.00e+00	1395.00
IUUC-Oga-088297	Otolemur garnettii	76.74	0.00e+00	1501.00
IUUC-Oar-089675	Ovis aries	71.56	0.00e+00	1373.00
IUUC-Ptr-091621	Pan troglodytes	77.69	0.00e+00	1520.00
IUUC-Pan-092118	Papio anubis	76.25	0.00e+00	1582.00
IUUC-Pma-094154	Petromyzon marinus	51.91	2.00e-114	406.00
IUUC-Pfo-097246	Poecilia formosa	61.62	0.00e+00	1517.00
IUUC-Pab-098551	Pongo abelii	76.73	0.00e+00	1504.00
IUUC-Pca-100158	Procavia capensis	73.85	0.00e+00	1440.00
IUUC-Pva-103160	Pteropus vampyrus	68.35	0.00e+00	1615.00
IUUC-Rno-105355	Rattus norvegicus	67.69	0.00e+00	1664.00
IUUC-Sha-107057	Sarcophilus harrisii	69.98	0.00e+00	1728.00
IUUC-Sar-113011	Sorex araneus	73.12	0.00e+00	1127.00
IUUC-Ssc-115761	Sus scrofa	75.80	0.00e+00	1550.00
IUUC-Tgu-116956	Taeniopygia guttata	68.95	0.00e+00	877.00
IUUC-Tru-118739	Takifugu rubripes	68.05	0.00e+00	1388.00
IUUC-Tsy-118827	Tarsius syrichta	85.22	0.00e+00	749.00
IUUC-Tni-119921	Tetraodon nigroviridis	75.04	0.00e+00	924.00
IUUC-Tbe-128017	Tupaia belangeri	75.50	0.00e+00	1481.00
IUUC-Ttr-128869	Tursiops truncatus	77.98	0.00e+00	1495.00
IUUC-Vpa-130427	Vicugna pacos	71.28	0.00e+00	703.00
IUUC-Xtr-132734	Xenopus tropicalis	75.25	0.00e+00	1491.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence