iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001999

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01098591

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000012785.1	ENSAMET00000014070.1	ENSAMEP00000013508.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.60e-115	384.5	650	1367

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 650  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 736
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 737  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 821
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 822  FLYLPVPLPQKQKVLPVfyfarephskpikflvsiskenssasevleslsqsvhvksenlrlaeviknrfhrvflpshsldtvspsd 908
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 909  tllcfellppelakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 995
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 996  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqgpgcttllstssleagdserdliqppelqlvtpvaegdagvpra 1082
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1083 waapdrgpvpstsgvssevlaggpvevgslpaservsrpeaavpgyqhpseamnahtpqffiykidasnreqrledkgdtplelged 1169
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1170 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1256
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1257 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1340
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1341 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1367
           ****************...********996 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

PEPRAGCQGP KRAGGGGLAR LSVPCWRIWP QRVAKIAGPG RKRRSPDPDA VADPGALWLS 60
TKRLKMSGGA SATGPRRGPP GLEEATSKKK QKDRANQESK DGDPRRDTER RTHSRLGRAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGAACCGA GAGCGGGTTG CCAGGGCCCT AAGAGGGCTG GCGGCGGCGG CCTCGCTCGG 60
TGAGTGGGAC GGGCCGCAAC TGGCCTGTCT GGCTGGAGCC AGGGAGGCCG CGACGGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003368	Anas platyrhynchos	67.84	0.00e+00	1774.00
IUUC-Aca-004267	Anolis carolinensis	65.60	0.00e+00	1684.00
IUUC-Ame-010970	Astyanax mexicanus	70.15	0.00e+00	1344.00
IUUC-Bta-012905	Bos taurus	92.41	0.00e+00	2512.00
IUUC-Cel-018257	Caenorhabditis elegans	43.00	4.00e-92	333.00
IUUC-Cja-018789	Callithrix jacchus	90.13	0.00e+00	2353.00
IUUC-Cfa-021004	Canis familiaris	95.72	0.00e+00	2622.00
IUUC-Cpo-021529	Cavia porcellus	87.56	0.00e+00	2246.00
IUUC-Csa-024035	Chlorocebus sabaeus	89.41	0.00e+00	2385.00
IUUC-Cho-025036	Choloepus hoffmanni	82.87	0.00e+00	1221.00
IUUC-Cin-025451	Ciona intestinalis	43.15	7.00e-86	312.00
IUUC-Csv-025931	Ciona savignyi	35.86	2.00e-109	389.00
IUUC-Dre-028556	Danio rerio	70.11	0.00e+00	1321.00
IUUC-Dno-029240	Dasypus novemcinctus	86.87	0.00e+00	2162.00
IUUC-Dor-030495	Dipodomys ordii	95.27	0.00e+00	1197.00
IUUC-Ete-032741	Echinops telfairi	91.81	0.00e+00	1860.00
IUUC-Eca-033661	Equus caballus	92.82	0.00e+00	2385.00
IUUC-Eeu-034648	Erinaceus europaeus	91.70	0.00e+00	831.00
IUUC-Fca-035646	Felis catus	96.66	0.00e+00	2605.00
IUUC-Fal-037094	Ficedula albicollis	66.98	0.00e+00	1725.00
IUUC-Gmo-038869	Gadus morhua	71.78	0.00e+00	847.00
IUUC-Gga-041170	Gallus gallus	64.56	0.00e+00	1663.00
IUUC-Gac-041901	Gasterosteus aculeatus	65.93	0.00e+00	1320.00
IUUC-Ggo-044708	Gorilla gorilla	90.51	0.00e+00	2346.00
IUUC-Hsa-046791	Homo sapiens	94.54	0.00e+00	1997.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	89.14	0.00e+00	2264.00
IUUC-Lch-050456	Latimeria chalumnae	52.66	0.00e+00	1189.00
IUUC-Loc-052861	Lepisosteus oculatus	59.79	0.00e+00	1147.00
IUUC-Laf-053788	Loxodonta africana	90.85	0.00e+00	2253.00
IUUC-Mcc-055693	Macaca mulatta	89.67	0.00e+00	2427.00
IUUC-Meu-055921	Macropus eugenii	78.95	0.00e+00	1472.00
IUUC-Mga-059879	Meleagris gallopavo	67.35	0.00e+00	1719.00
IUUC-Mmr-060802	Microcebus murinus	92.08	0.00e+00	2395.00
IUUC-Mdo-061856	Monodelphis domestica	77.32	0.00e+00	1561.00
IUUC-Mmu-063874	Mus musculus	88.15	0.00e+00	2248.00
IUUC-Mpu-066166	Mustela putorius furo	96.61	0.00e+00	2640.00
IUUC-Nle-070161	Nomascus leucogenys	89.91	0.00e+00	2399.00
IUUC-Opr-071015	Ochotona princeps	93.77	0.00e+00	1949.00
IUUC-Ont-072308	Oreochromis niloticus	66.29	0.00e+00	1368.00
IUUC-Oan-072723	Ornithorhynchus anatinus	65.65	0.00e+00	1605.00
IUUC-Ocu-073938	Oryctolagus cuniculus	90.23	0.00e+00	2471.00
IUUC-Ola-086375	Oryzias latipes	68.07	0.00e+00	1354.00
IUUC-Oga-088297	Otolemur garnettii	90.73	0.00e+00	2330.00
IUUC-Oar-089675	Ovis aries	89.38	0.00e+00	1734.00
IUUC-Ptr-091621	Pan troglodytes	94.16	0.00e+00	1994.00
IUUC-Pan-092118	Papio anubis	90.93	0.00e+00	2579.00
IUUC-Pfo-097246	Poecilia formosa	59.28	0.00e+00	1427.00
IUUC-Pab-098551	Pongo abelii	93.58	0.00e+00	1972.00
IUUC-Pca-100158	Procavia capensis	86.79	0.00e+00	2229.00
IUUC-Pva-103160	Pteropus vampyrus	91.99	0.00e+00	2313.00
IUUC-Rno-105355	Rattus norvegicus	88.66	0.00e+00	2290.00
IUUC-Sha-107057	Sarcophilus harrisii	73.13	0.00e+00	1941.00
IUUC-Sar-113011	Sorex araneus	90.73	0.00e+00	1514.00
IUUC-Ssc-115761	Sus scrofa	93.54	0.00e+00	2568.00
IUUC-Tgu-116956	Taeniopygia guttata	63.10	0.00e+00	794.00
IUUC-Tru-118739	Takifugu rubripes	65.63	0.00e+00	1362.00
IUUC-Tsy-118827	Tarsius syrichta	83.66	0.00e+00	1253.00
IUUC-Tni-119921	Tetraodon nigroviridis	61.22	0.00e+00	1397.00
IUUC-Tbe-128017	Tupaia belangeri	91.28	0.00e+00	1913.00
IUUC-Ttr-128869	Tursiops truncatus	92.19	0.00e+00	2315.00
IUUC-Vpa-130427	Vicugna pacos	97.01	0.00e+00	937.00
IUUC-Xtr-132734	Xenopus tropicalis	62.04	0.00e+00	1631.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence