iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000015154.1	ENSLACT00000017328.1	ENSLACP00000017202.1
ENSLACG00000015154.1	ENSLACT00000017329.1	ENSLACP00000017203.1
ENSLACG00000015154.1	ENSLACT00000017330.1	ENSLACP00000017204.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-114	383.2	536	1279

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 536  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFETEINYSNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 622
           7******************************999***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks++ c+ c +vs +++p
   Q: 623  YVQHDAQEFMAFLLDGLHEDLNRIQNKPYTETLDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLHCPVCSKVSITFDP 707
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 708  FLYLPVPLPQKQKVLTVfyfakephkkpvkifkkiycvmsfalsvcdgpslqtlihiytqklncanfvsssslppppqkkspcilpp 794
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 795  sqlsvfsslwsgssgsgggmmavgqrlqvssipiskcaacqksqqpeeeklkrctrcyqvgycnqtcqknhwpdhktqckpenigcp 881
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 882  fllsvpesrltysrltqllegysrqrysvsvfqppfqpgrlspeqtaisrsdlrpptserqeasvkscvpsstevgdgdreqefkpi 968
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 969  psdspsepllascgpkpaestaslssgdkdsllsrdsgyserskesweesraeketsyeksikpeaavpgyqhpvessscrslqffi 1055
           *************************************************************************************** PP
   S: 186  ...................................................................slqdcLesftkeeelegenk 205
                                                                              +l++cL+ ftk+e l  e++
   Q: 1056 laidsankeqkledkgdtplelaedgslalvwknnerakeyvlveskeleyeedpgsaseaaraghfTLEQCLNLFTKPEVLAPEEA 1142
           *************************************************************************************** PP
   S: 206  yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGsls 291
           +yc+kck+++ea+k+l+l++lP+vLi++LkRfsf++  +++ kin+ v+fp + Ldls+fc+ ++++  ++  Y+L+av++H+G++ 
   Q: 1143 WYCPKCKQHREASKQLMLWRLPNVLIIQLKRFSFRNFIWRD-KINDMVDFPVRnLDLSKFCIGQKDSR-QPPVYDLYAVINHYGGMI 1227
           *************************************8886.**********9**********77765.6***************** PP
   S: 292  sGHYvayvknekgk........WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +GHY+ay++  ++k        W lfdDs+Vt+v+e++v +   + aYvlfY+r+
   Q: 1228 GGHYTAYARLPSDKnsqrsdvgWRLFDDSTVTAVDESQVAT---RCAYVLFYRRQ 1279
           *********9444444567788*******************...*********96 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MSSTADVAGQ KRVPRGLEDT MNKKKQKDRV NQESKEGRKV SSSDKNRGKS MRVWSMFCQA 60
CTGSVFLKNI FGLKESLPEW EEREAADPGS SLCLSVSDGL CCVDGRQWSC SFHEEIEGSC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGTTCCTT TTTGGAGCGT CCTACCGCAA AGAGTTGCCA AGATAGCTGG ACCAGGAAGA 60
AAGCGCCAAA CCCCTGAACC AGATTCTATC AGTGACCCTA GCGGGCCCTC TGTGTCCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	60.63	0.00e+00	1139.00
IUUC-Apl-003368	Anas platyrhynchos	54.99	0.00e+00	1271.00
IUUC-Aca-004267	Anolis carolinensis	67.14	0.00e+00	1180.00
IUUC-Ame-010970	Astyanax mexicanus	62.98	0.00e+00	1104.00
IUUC-Bta-012905	Bos taurus	60.67	0.00e+00	1122.00
IUUC-Cja-018789	Callithrix jacchus	52.05	0.00e+00	1203.00
IUUC-Cfa-021004	Canis familiaris	67.85	0.00e+00	1127.00
IUUC-Cpo-021529	Cavia porcellus	52.20	0.00e+00	1181.00
IUUC-Csa-024035	Chlorocebus sabaeus	53.41	0.00e+00	1193.00
IUUC-Cho-025036	Choloepus hoffmanni	78.10	2.00e-150	527.00
IUUC-Cin-025451	Ciona intestinalis	38.65	3.00e-71	263.00
IUUC-Dre-028556	Danio rerio	68.38	0.00e+00	1097.00
IUUC-Dno-029240	Dasypus novemcinctus	61.83	0.00e+00	1041.00
IUUC-Dor-030495	Dipodomys ordii	58.31	0.00e+00	776.00
IUUC-Ete-032741	Echinops telfairi	68.07	0.00e+00	1132.00
IUUC-Eca-033661	Equus caballus	52.31	0.00e+00	1221.00
IUUC-Eeu-034648	Erinaceus europaeus	85.66	3.00e-127	449.00
IUUC-Fca-035646	Felis catus	68.19	0.00e+00	1117.00
IUUC-Fal-037094	Ficedula albicollis	54.97	0.00e+00	1363.00
IUUC-Gmo-038869	Gadus morhua	63.92	3.00e-165	576.00
IUUC-Gga-041170	Gallus gallus	53.54	0.00e+00	1312.00
IUUC-Gac-041901	Gasterosteus aculeatus	61.73	0.00e+00	1047.00
IUUC-Ggo-044708	Gorilla gorilla	64.46	0.00e+00	1154.00
IUUC-Hsa-046791	Homo sapiens	60.11	0.00e+00	1143.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	54.71	0.00e+00	1160.00
IUUC-Loc-052861	Lepisosteus oculatus	60.07	0.00e+00	912.00
IUUC-Laf-053788	Loxodonta africana	64.51	0.00e+00	1137.00
IUUC-Mcc-055693	Macaca mulatta	51.62	0.00e+00	1157.00
IUUC-Meu-055921	Macropus eugenii	63.55	0.00e+00	964.00
IUUC-Mga-059879	Meleagris gallopavo	56.97	0.00e+00	1293.00
IUUC-Mmr-060802	Microcebus murinus	51.74	0.00e+00	1185.00
IUUC-Mdo-061856	Monodelphis domestica	63.36	0.00e+00	1160.00
IUUC-Mmu-063874	Mus musculus	53.69	0.00e+00	1185.00
IUUC-Mpu-066166	Mustela putorius furo	68.19	0.00e+00	1120.00
IUUC-Nle-070161	Nomascus leucogenys	51.12	0.00e+00	1202.00
IUUC-Opr-071015	Ochotona princeps	60.75	0.00e+00	1137.00
IUUC-Ont-072308	Oreochromis niloticus	68.29	0.00e+00	1126.00
IUUC-Oan-072723	Ornithorhynchus anatinus	56.65	0.00e+00	1340.00
IUUC-Ocu-073938	Oryctolagus cuniculus	63.31	0.00e+00	1139.00
IUUC-Ola-086375	Oryzias latipes	54.72	0.00e+00	1132.00
IUUC-Oga-088297	Otolemur garnettii	60.47	0.00e+00	1118.00
IUUC-Oar-089675	Ovis aries	65.80	0.00e+00	1046.00
IUUC-Ptr-091621	Pan troglodytes	64.16	0.00e+00	1140.00
IUUC-Pan-092118	Papio anubis	51.62	0.00e+00	1186.00
IUUC-Pma-094154	Petromyzon marinus	67.59	1.00e-83	303.00
IUUC-Pfo-097246	Poecilia formosa	66.37	0.00e+00	1074.00
IUUC-Pab-098551	Pongo abelii	63.65	0.00e+00	1131.00
IUUC-Pca-100158	Procavia capensis	64.68	0.00e+00	1149.00
IUUC-Pva-103160	Pteropus vampyrus	64.30	0.00e+00	1113.00
IUUC-Rno-105355	Rattus norvegicus	53.36	0.00e+00	1190.00
IUUC-Sha-107057	Sarcophilus harrisii	58.12	0.00e+00	1196.00
IUUC-Sar-113011	Sorex araneus	55.09	0.00e+00	735.00
IUUC-Ssc-115761	Sus scrofa	53.89	0.00e+00	1195.00
IUUC-Tgu-116956	Taeniopygia guttata	61.14	6.00e-166	577.00
IUUC-Tru-118739	Takifugu rubripes	65.91	0.00e+00	1087.00
IUUC-Tsy-118827	Tarsius syrichta	78.61	7.00e-145	508.00
IUUC-Tni-119921	Tetraodon nigroviridis	64.69	0.00e+00	1062.00
IUUC-Tbe-128017	Tupaia belangeri	57.79	0.00e+00	1154.00
IUUC-Ttr-128869	Tursiops truncatus	52.61	0.00e+00	1187.00
IUUC-Vpa-130427	Vicugna pacos	56.88	8.00e-148	518.00
IUUC-Xtr-132734	Xenopus tropicalis	54.51	0.00e+00	1248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence