iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000015212.1	ENSSHAT00000018068.1	ENSSHAP00000017920.1
ENSSHAG00000015212.1	ENSSHAT00000018069.1	ENSSHAP00000017921.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-116	388.5	649	1372

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 649  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFEAEINYSNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 735
           7******************************99****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlF+gq+ks+++c+ c +vs +++p
   Q: 736  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaqeAWQRHKMRNDSFIVDLFHGQYKSKLVCPVCSKVSITFDP 820
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 821  FLYLPVPLPQKQKVLTVyyfakephkkpvkflvsiskenssamevldslaqsvhvkpeslrlaeviknrfhrvflpshsldtvsptd 907
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 908  lllcfevlspelakervvvlqvqqrpqvpsvpiakcaacqkkqqsedeklkrctrcyrvgycnqvcqkthwpdhkglcrpenigfpf 994
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 995  fisvpesrltyarlaqllegyarysvsvfqppfqlgrvspeqspqvlssstspvlstleagggdrdlrpspesqvsptvaelgdtga 1081
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1082 srsraapdrgsvpsldtglsestvsmaneggfskesagerllrpeaavpgyqhpaevlsahpppffinkidatnkeqkledkgeapl 1168
           *************************************************************************************** PP
   S: 186  ...............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkk 225
                                                          +l++cL+ ftk+e l  e+++yc+kck+++ea+k+l+l++
   Q: 1169 dlsddcslalvwknnerlkefvlvgskelecvedpssaseaaraghfTLEQCLNLFTKPEVLAPEEAWYCPKCKQHREASKQLMLWR 1255
           *************************************************************************************** PP
   S: 226  lPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk...... 305
           lP+vLi++LkRfsf++  +++ kin+ vefpl+ Ldls+fc+ ++++  +  +Y+L+av++H+G++ +GHY+ay++  ++k      
   Q: 1256 LPNVLIIQLKRFSFRSFIWRD-KINDMVEFPLRnLDLSKFCIGQKDDR-QLPTYDLYAVINHYGGMIGGHYTAYARLPSDKnsqrsd 1340
           *****************8886.*********************77665.6**************************94444445677 PP
   S: 306  ..WllfdDskVtevkeeevleetgstaYvlfYkrr 338
             W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1341 vgWRLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1372
           88*******************...********996 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

RSFVPHWRVW PQRIAKIAGP GRKRRTPDPD SITDPGGFWV SSKRLKMSGG ASATGQRRCP 60
QGLEDATNKK KQKDRVNQES KDGEPKRGGD HMAVPGENMC KISSPLMICI PCSGVEGGIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTCATTTG TTCCTCACTG GAGAGTTTGG CCACAGAGAA TCGCCAAGAT AGCTGGGCCA 60
GGAAGAAAAC GTCGAACCCC TGACCCAGAC TCCATCACTG ACCCCGGTGG ATTCTGGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	75.81	0.00e+00	1844.00
IUUC-Apl-003368	Anas platyrhynchos	70.33	0.00e+00	1850.00
IUUC-Aca-004267	Anolis carolinensis	70.43	0.00e+00	1750.00
IUUC-Ame-010970	Astyanax mexicanus	73.06	0.00e+00	1373.00
IUUC-Bta-012905	Bos taurus	72.76	0.00e+00	1938.00
IUUC-Cel-018257	Caenorhabditis elegans	44.21	2.00e-90	327.00
IUUC-Cja-018789	Callithrix jacchus	73.05	0.00e+00	1865.00
IUUC-Cfa-021004	Canis familiaris	72.55	0.00e+00	1947.00
IUUC-Cpo-021529	Cavia porcellus	75.59	0.00e+00	1825.00
IUUC-Csa-024035	Chlorocebus sabaeus	75.68	0.00e+00	1863.00
IUUC-Cho-025036	Choloepus hoffmanni	69.80	0.00e+00	949.00
IUUC-Cin-025451	Ciona intestinalis	42.74	1.00e-84	308.00
IUUC-Dre-028556	Danio rerio	71.50	0.00e+00	1350.00
IUUC-Dno-029240	Dasypus novemcinctus	74.68	0.00e+00	1648.00
IUUC-Dor-030495	Dipodomys ordii	80.61	0.00e+00	1020.00
IUUC-Ete-032741	Echinops telfairi	79.63	0.00e+00	1582.00
IUUC-Eca-033661	Equus caballus	76.71	0.00e+00	1827.00
IUUC-Eeu-034648	Erinaceus europaeus	80.87	0.00e+00	665.00
IUUC-Fca-035646	Felis catus	72.40	0.00e+00	1947.00
IUUC-Fal-037094	Ficedula albicollis	72.42	0.00e+00	1770.00
IUUC-Gmo-038869	Gadus morhua	67.24	0.00e+00	1260.00
IUUC-Gga-041170	Gallus gallus	78.77	0.00e+00	1570.00
IUUC-Gac-041901	Gasterosteus aculeatus	70.88	0.00e+00	1326.00
IUUC-Ggo-044708	Gorilla gorilla	73.16	0.00e+00	1863.00
IUUC-Hsa-046791	Homo sapiens	80.37	0.00e+00	1632.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	75.42	0.00e+00	1743.00
IUUC-Lch-050456	Latimeria chalumnae	57.55	0.00e+00	1193.00
IUUC-Loc-052861	Lepisosteus oculatus	61.24	0.00e+00	1190.00
IUUC-Laf-053788	Loxodonta africana	77.16	0.00e+00	1781.00
IUUC-Mcc-055693	Macaca mulatta	71.56	0.00e+00	1903.00
IUUC-Meu-055921	Macropus eugenii	89.95	0.00e+00	1672.00
IUUC-Mga-059879	Meleagris gallopavo	68.94	0.00e+00	1770.00
IUUC-Mmr-060802	Microcebus murinus	73.56	0.00e+00	1881.00
IUUC-Mdo-061856	Monodelphis domestica	92.60	0.00e+00	1859.00
IUUC-Mmu-063874	Mus musculus	76.37	0.00e+00	1834.00
IUUC-Mpu-066166	Mustela putorius furo	73.22	0.00e+00	1946.00
IUUC-Nle-070161	Nomascus leucogenys	73.01	0.00e+00	1895.00
IUUC-Opr-071015	Ochotona princeps	79.48	0.00e+00	1598.00
IUUC-Ont-072308	Oreochromis niloticus	69.14	0.00e+00	1421.00
IUUC-Oan-072723	Ornithorhynchus anatinus	70.12	0.00e+00	1637.00
IUUC-Ocu-073938	Oryctolagus cuniculus	73.27	0.00e+00	1952.00
IUUC-Ola-086375	Oryzias latipes	61.71	0.00e+00	1467.00
IUUC-Oga-088297	Otolemur garnettii	73.00	0.00e+00	1841.00
IUUC-Oar-089675	Ovis aries	76.21	0.00e+00	1446.00
IUUC-Ptr-091621	Pan troglodytes	80.27	0.00e+00	1634.00
IUUC-Pan-092118	Papio anubis	72.25	0.00e+00	1989.00
IUUC-Pfo-097246	Poecilia formosa	62.25	0.00e+00	1491.00
IUUC-Pab-098551	Pongo abelii	79.49	0.00e+00	1611.00
IUUC-Pca-100158	Procavia capensis	73.74	0.00e+00	1739.00
IUUC-Pva-103160	Pteropus vampyrus	76.51	0.00e+00	1769.00
IUUC-Rno-105355	Rattus norvegicus	76.22	0.00e+00	1795.00
IUUC-Sar-113011	Sorex araneus	75.99	0.00e+00	1186.00
IUUC-Ssc-115761	Sus scrofa	72.92	0.00e+00	1971.00
IUUC-Tgu-116956	Taeniopygia guttata	65.79	0.00e+00	829.00
IUUC-Tru-118739	Takifugu rubripes	69.05	0.00e+00	1392.00
IUUC-Tsy-118827	Tarsius syrichta	73.53	0.00e+00	960.00
IUUC-Tni-119921	Tetraodon nigroviridis	62.23	0.00e+00	1431.00
IUUC-Tbe-128017	Tupaia belangeri	77.51	0.00e+00	1573.00
IUUC-Ttr-128869	Tursiops truncatus	76.76	0.00e+00	1785.00
IUUC-Vpa-130427	Vicugna pacos	78.83	0.00e+00	760.00
IUUC-Xtr-132734	Xenopus tropicalis	62.18	0.00e+00	1649.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence