iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115761

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU856115

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000011375.2	ENSSSCT00000012453.2	ENSSSCP00000012128.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.50e-115	384.4	640	1357

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 640  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 726
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 727  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 811
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 812  FLYLPVPLPQKQKVLPVfyfarephskpikflvsiskenssasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldtvspsd 898
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 899  tllcfellspelakervvvlevqqrpqvpsipiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 985
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 986  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqgpgcttmlstssleagdserdpvqppelqlvtpvaegdtgvpra 1072
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1073 waspdrgpapstsgvssemlasvsaevgslpagervsrpeaavpgyqhpseamnahtpqffiykidasnreqrledkgdnplelged 1159
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1160 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1246
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1247 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1330
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1331 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1357
           ****************...********996 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

LIRLSVPCWK IWPQRVAKIA GPGRKRRSPD PDAVADPGAL WLSTKRLKMS GGASTTGPRR 60
GPLGLEEATS KKKQKDRANQ ESKDGDPRRG GSVNPRGLMT FCSSLPVECV GFPSVILSLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCATTAGGC TGTCAGTTCC TTGCTGGAAG ATTTGGCCAC AAAGAGTTGC CAAGATAGCT 60
GGGCCAGGAA GAAAGCGCCG TAGCCCTGAC CCAGACGCCG TTGCCGACCC TGGGGCACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	92.77	0.00e+00	2517.00
IUUC-Apl-003368	Anas platyrhynchos	67.98	0.00e+00	1796.00
IUUC-Aca-004267	Anolis carolinensis	67.96	0.00e+00	1679.00
IUUC-Ame-010970	Astyanax mexicanus	70.54	0.00e+00	1347.00
IUUC-Bta-012905	Bos taurus	92.75	0.00e+00	2526.00
IUUC-Cja-018789	Callithrix jacchus	89.62	0.00e+00	2337.00
IUUC-Cfa-021004	Canis familiaris	92.88	0.00e+00	2523.00
IUUC-Cpo-021529	Cavia porcellus	86.77	0.00e+00	2266.00
IUUC-Csa-024035	Chlorocebus sabaeus	92.87	0.00e+00	2338.00
IUUC-Cho-025036	Choloepus hoffmanni	80.60	0.00e+00	1221.00
IUUC-Cin-025451	Ciona intestinalis	43.67	1.00e-86	314.00
IUUC-Csv-025931	Ciona savignyi	36.73	2.00e-111	396.00
IUUC-Dre-028556	Danio rerio	68.74	0.00e+00	1328.00
IUUC-Dno-029240	Dasypus novemcinctus	90.94	0.00e+00	2093.00
IUUC-Dor-030495	Dipodomys ordii	94.78	0.00e+00	1194.00
IUUC-Ete-032741	Echinops telfairi	92.31	0.00e+00	1865.00
IUUC-Eca-033661	Equus caballus	91.58	0.00e+00	2361.00
IUUC-Eeu-034648	Erinaceus europaeus	91.93	0.00e+00	825.00
IUUC-Fca-035646	Felis catus	93.05	0.00e+00	2501.00
IUUC-Fal-037094	Ficedula albicollis	66.98	0.00e+00	1744.00
IUUC-Gmo-038869	Gadus morhua	72.37	0.00e+00	846.00
IUUC-Gga-041170	Gallus gallus	68.07	0.00e+00	1682.00
IUUC-Gac-041901	Gasterosteus aculeatus	68.83	0.00e+00	1319.00
IUUC-Ggo-044708	Gorilla gorilla	90.52	0.00e+00	2349.00
IUUC-Hsa-046791	Homo sapiens	94.74	0.00e+00	1998.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	89.66	0.00e+00	2264.00
IUUC-Lch-050456	Latimeria chalumnae	53.24	0.00e+00	1203.00
IUUC-Loc-052861	Lepisosteus oculatus	60.13	0.00e+00	1155.00
IUUC-Laf-053788	Loxodonta africana	89.48	0.00e+00	2238.00
IUUC-Mcc-055693	Macaca mulatta	89.39	0.00e+00	2421.00
IUUC-Meu-055921	Macropus eugenii	78.85	0.00e+00	1472.00
IUUC-Mga-059879	Meleagris gallopavo	67.15	0.00e+00	1729.00
IUUC-Mmr-060802	Microcebus murinus	91.64	0.00e+00	2395.00
IUUC-Mdo-061856	Monodelphis domestica	77.40	0.00e+00	1559.00
IUUC-Mmu-063874	Mus musculus	87.09	0.00e+00	2262.00
IUUC-Mpu-066166	Mustela putorius furo	93.37	0.00e+00	2528.00
IUUC-Nle-070161	Nomascus leucogenys	89.84	0.00e+00	2395.00
IUUC-Opr-071015	Ochotona princeps	93.10	0.00e+00	1937.00
IUUC-Ont-072308	Oreochromis niloticus	67.47	0.00e+00	1386.00
IUUC-Oan-072723	Ornithorhynchus anatinus	67.61	0.00e+00	1575.00
IUUC-Ocu-073938	Oryctolagus cuniculus	90.23	0.00e+00	2422.00
IUUC-Ola-086375	Oryzias latipes	68.17	0.00e+00	1355.00
IUUC-Oga-088297	Otolemur garnettii	89.68	0.00e+00	2312.00
IUUC-Oar-089675	Ovis aries	89.17	0.00e+00	1729.00
IUUC-Ptr-091621	Pan troglodytes	94.35	0.00e+00	1994.00
IUUC-Pan-092118	Papio anubis	90.10	0.00e+00	2529.00
IUUC-Pma-094154	Petromyzon marinus	51.78	3.00e-114	405.00
IUUC-Pfo-097246	Poecilia formosa	59.58	0.00e+00	1429.00
IUUC-Pab-098551	Pongo abelii	93.78	0.00e+00	1973.00
IUUC-Pca-100158	Procavia capensis	85.66	0.00e+00	2216.00
IUUC-Pva-103160	Pteropus vampyrus	90.61	0.00e+00	2297.00
IUUC-Rno-105355	Rattus norvegicus	87.44	0.00e+00	2270.00
IUUC-Sha-107057	Sarcophilus harrisii	72.78	0.00e+00	1971.00
IUUC-Sar-113011	Sorex araneus	90.75	0.00e+00	1514.00
IUUC-Tgu-116956	Taeniopygia guttata	64.33	0.00e+00	793.00
IUUC-Tru-118739	Takifugu rubripes	67.62	0.00e+00	1367.00
IUUC-Tsy-118827	Tarsius syrichta	82.83	0.00e+00	1241.00
IUUC-Tni-119921	Tetraodon nigroviridis	61.64	0.00e+00	1407.00
IUUC-Tbe-128017	Tupaia belangeri	91.48	0.00e+00	1916.00
IUUC-Ttr-128869	Tursiops truncatus	91.19	0.00e+00	2298.00
IUUC-Vpa-130427	Vicugna pacos	96.58	0.00e+00	934.00
IUUC-Xtr-132734	Xenopus tropicalis	61.99	0.00e+00	1633.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence