iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000008619.3	ENSXETT00000018840.3	ENSXETP00000018840.3
ENSXETG00000008619.3	ENSXETT00000018836.2	ENSXETP00000018836.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.00e-115	383.6	642	1365

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++ + ++++++n +np ++ g+l+ s++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 642  TGLVNLGNTCFMNSVIQSLSNTRELRDYFQDrSFESEINCNNPLGTGGRLAVSFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 728
           7*****************************9999***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeed...kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++e  dea+ ++k++n+s+++dlFqgq+ks+++c+ c++vs +++pfl
   Q: 729  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDgrpDEEVADEAWLRHKMRNDSFVVDLFQGQYKSKLVCPVCAKVSITFDPFL 815
           ********************************99982223455566***************************************** PP
   S: 171  dlslpvpgkeetkke........................................................................ 185
           +l++p+p+k++  +                                                                         
   Q: 816  YLPVPLPQKQKVLTVyyfarephkkpikflvsiskenssaaevlesisksvrvkaenlqlaevvknrfqrifrpscsldsvspndll 902
           **********87555************************************************************************ PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 903  fcfevlskelskervvvfqvqqrpqvpsipitkcaacqkkqmseeeklkrctrcyrvgycnqvcqkshwpdhktacrpenigypfli 989
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 990  svpesrltysrlaqllegyarysvnvfqppfipgrtspdhapqpsdlpllgesseeekdfhsvqssqttlppltclsasgdsgivhg 1076
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1077 kppgdrvslystdsgfsehstdtvremdsggeketiyeksvkpeaavagfqqsesvnvhasafyinvidpnnkemkledkgesplel 1163
           *************************************************************************************** PP
   S: 186  .............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklP 227
                                                        +l++cL+ ftk+e l  e+++yc+kc++++ea+k+l+l++lP
   Q: 1164 tedcslalvwknnerakefvlveskeleceedpgsaseaaraglfTLDQCLNLFTKPEVLAPEEAWYCPKCNQHREASKQLMLWRLP 1250
           *************************************************************************************** PP
   S: 228  evLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........ 305
           ++Li++LkRfsf+   +++ kin+ v+fp + Ldls fc+ ++e+ +++ +Y+L+av++H+G++ +GHY+ay++  ++k        
   Q: 1251 NILIIQLKRFSFRTFIWRD-KINDMVDFPVRnLDLSTFCIGQKED-HQRPIYDLYAVINHYGGMIGGHYTAYARLPNEKnsqrsdvg 1335
           **************98886.**********9**********6665.57**************************9544445677888 PP
   S: 306  WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1336 WRLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1365
           *******************...********996 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

CWQRVYPQRV AKIAGPSRKR RPDPDSVTDP GGPSVYTKRQ KMSHPAEGAN QRRVTRGTAD 60
AINRKKQKDK ANQESKEGKA PTNAGPQRLH LLPNFLVKYT DGLLSNIFIT VLSFPTLLFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGAAAAA GGGACCGGAA GCGGAAGAAG TCTTCATTGT TTGCGGCAGG TGAAGCTGCC 60
GGTGCTGGAA GCGAGTGGGT GGGTAGCTGG GCCTGACGGC GCGGAGAGAG CACAGAGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:0016579--P:protein deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	71.17	0.00e+00	1462.00
IUUC-Apl-003368	Anas platyrhynchos	64.30	0.00e+00	1672.00
IUUC-Aca-004267	Anolis carolinensis	65.11	0.00e+00	1565.00
IUUC-Ame-010970	Astyanax mexicanus	72.52	0.00e+00	1360.00
IUUC-Bta-012905	Bos taurus	72.58	0.00e+00	1425.00
IUUC-Cel-018257	Caenorhabditis elegans	42.34	5.00e-95	342.00
IUUC-Cja-018789	Callithrix jacchus	61.81	0.00e+00	1563.00
IUUC-Cfa-021004	Canis familiaris	71.08	0.00e+00	1427.00
IUUC-Cpo-021529	Cavia porcellus	62.42	0.00e+00	1514.00
IUUC-Csa-024035	Chlorocebus sabaeus	60.90	0.00e+00	1550.00
IUUC-Cho-025036	Choloepus hoffmanni	53.25	0.00e+00	752.00
IUUC-Cin-025451	Ciona intestinalis	41.65	1.00e-83	304.00
IUUC-Dre-028556	Danio rerio	73.28	0.00e+00	1366.00
IUUC-Dno-029240	Dasypus novemcinctus	62.89	0.00e+00	1399.00
IUUC-Dor-030495	Dipodomys ordii	72.31	0.00e+00	901.00
IUUC-Ete-032741	Echinops telfairi	73.73	0.00e+00	1402.00
IUUC-Eca-033661	Equus caballus	61.37	0.00e+00	1541.00
IUUC-Eeu-034648	Erinaceus europaeus	79.43	1.00e-173	603.00
IUUC-Fca-035646	Felis catus	70.98	0.00e+00	1434.00
IUUC-Fal-037094	Ficedula albicollis	76.83	0.00e+00	1524.00
IUUC-Gmo-038869	Gadus morhua	66.67	0.00e+00	1242.00
IUUC-Gga-041170	Gallus gallus	75.62	0.00e+00	1479.00
IUUC-Gac-041901	Gasterosteus aculeatus	69.28	0.00e+00	1303.00
IUUC-Ggo-044708	Gorilla gorilla	61.34	0.00e+00	1565.00
IUUC-Hsa-046791	Homo sapiens	71.03	0.00e+00	1448.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	61.71	0.00e+00	1477.00
IUUC-Lch-050456	Latimeria chalumnae	69.61	0.00e+00	1113.00
IUUC-Loc-052861	Lepisosteus oculatus	64.28	0.00e+00	1165.00
IUUC-Laf-053788	Loxodonta africana	73.73	0.00e+00	1406.00
IUUC-Mcc-055693	Macaca mulatta	60.29	0.00e+00	1545.00
IUUC-Meu-055921	Macropus eugenii	74.54	0.00e+00	1226.00
IUUC-Mga-059879	Meleagris gallopavo	63.46	0.00e+00	1612.00
IUUC-Mmr-060802	Microcebus murinus	61.39	0.00e+00	1546.00
IUUC-Mdo-061856	Monodelphis domestica	74.39	0.00e+00	1394.00
IUUC-Mmu-063874	Mus musculus	60.85	0.00e+00	1521.00
IUUC-Mpu-066166	Mustela putorius furo	70.71	0.00e+00	1421.00
IUUC-Nle-070161	Nomascus leucogenys	61.48	0.00e+00	1575.00
IUUC-Opr-071015	Ochotona princeps	72.82	0.00e+00	1394.00
IUUC-Ont-072308	Oreochromis niloticus	71.31	0.00e+00	1375.00
IUUC-Oan-072723	Ornithorhynchus anatinus	73.36	0.00e+00	1385.00
IUUC-Ocu-073938	Oryctolagus cuniculus	74.34	0.00e+00	1421.00
IUUC-Ola-086375	Oryzias latipes	70.33	0.00e+00	1338.00
IUUC-Oga-088297	Otolemur garnettii	60.62	0.00e+00	1526.00
IUUC-Oar-089675	Ovis aries	73.72	0.00e+00	1279.00
IUUC-Ptr-091621	Pan troglodytes	70.84	0.00e+00	1451.00
IUUC-Pan-092118	Papio anubis	60.87	0.00e+00	1620.00
IUUC-Pma-094154	Petromyzon marinus	51.20	6.00e-115	407.00
IUUC-Pfo-097246	Poecilia formosa	61.14	0.00e+00	1446.00
IUUC-Pab-098551	Pongo abelii	70.27	0.00e+00	1426.00
IUUC-Pca-100158	Procavia capensis	58.70	0.00e+00	1441.00
IUUC-Pva-103160	Pteropus vampyrus	61.38	0.00e+00	1484.00
IUUC-Rno-105355	Rattus norvegicus	60.70	0.00e+00	1509.00
IUUC-Sha-107057	Sarcophilus harrisii	62.00	0.00e+00	1596.00
IUUC-Sar-113011	Sorex araneus	66.51	0.00e+00	1050.00
IUUC-Ssc-115761	Sus scrofa	61.69	0.00e+00	1601.00
IUUC-Tgu-116956	Taeniopygia guttata	63.95	0.00e+00	796.00
IUUC-Tru-118739	Takifugu rubripes	69.48	0.00e+00	1354.00
IUUC-Tsy-118827	Tarsius syrichta	80.87	0.00e+00	704.00
IUUC-Tni-119921	Tetraodon nigroviridis	69.95	0.00e+00	1333.00
IUUC-Tbe-128017	Tupaia belangeri	71.82	0.00e+00	1380.00
IUUC-Ttr-128869	Tursiops truncatus	60.72	0.00e+00	1484.00
IUUC-Vpa-130427	Vicugna pacos	68.54	0.00e+00	657.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence