iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000174776.10	ENST00000308378.7	ENSP00000311343.3
ENSG00000174776.10	ENST00000472600.5	ENSP00000419130.1
ENSG00000174776.10	ENST00000479765.5	ENSP00000419749.1
ENSG00000174776.10	ENST00000493061.1	ENSP00000418539.1
ENSG00000174776.10	ENST00000460448.5	ENSP00000417090.1
ENSG00000174776.10	ENST00000466760.5	ENSP00000418718.1
ENSG00000174776.10	ENST00000488012.5	ENSP00000419917.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Disease-associated Variation
ClinVar	GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.20e-25	88.1	282	313
UBD/Beta-Prp	7.10e-45	155.1	147	501

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrt 32
           H d++ c af +  +lv+Gs+Dg i +W+ +t
   Q: 282  HHDDILCAAFlPPQTLVTGSYDGEIVLWNNST 313
           8999******955889************9665 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgh..eaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
           h++ +tcv +    ++++++ + +t+  w ++tg++++++ g+  +ae++++ ++ ++  l+tgs+D+t+k+wd++ g c htl+  +d ++
   Q: 147  HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGChgNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAV 237
           5667899***889999************************87622567*********99****************7.568899995555555 PP
   S: 99   slsfsp.sgdklvsGshdrtirvwdletgqclee.......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl....... 175
           ++s     ++k++++++ r i v+  ++   +           + hd++ + + ++p  + lv+Gs+D+ + lW+ +t++  + l       
   Q: 238  DISQILiLKKKILVTGWERAITVFRPQNFNQFFIqpeewkgGIQHHDDILCAAFLPP--QTLVTGSYDGEIVLWNNSTENAHHVLhpdyqrl 327
           555444377**************8777776665567777756667777777777777..99***************9999999997666666 PP
   S: 176  ..tgghtdsvyslsfdsng...........................................kelvsgsldgtvklwdlqtgecvrtlnght 222
             ++ +t++ + ls  +++                                             lvs++  g+v++wd+ +++ + ++ +h+
   Q: 328  lkSKLDTKPQKLLSAGRSQpshpmadhsttgvrnfeidtegknavmrlcflkarkntavtggANLVSCGGSGYVRFWDIYKKQLLAEFLAHS 419
           664445555556653333355566666666677777777779999999999999999*********************************** PP
   S: 223  dnvksvrfspnderlvsgs.sDgsiriW.......dlrsgdllktlqlhn......ssvisvavlsfgdnvlvlgse.dskv 289
              + +  +++ +r+++++  Dg ++iW       ++ +++++k+ +l +      ++++s  + ++g++ l+  s+ d+++
   Q: 420  GVGSIIMSTDKMNRYLTTGdLDGWLKIWnieeyclNSSKNKITKAPTLIRsfqpheDRISSLEMCEPGGQLLIISSSaDCSI 501
           988887777777777777769*******77777776566655555444447777779****999999988776666659887 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAWREKSKKR LNMTSFNIAQ GIHAFDYHSR LNLIATAGIN NKVCLWNPYV VSKPVGVLWG 60
HSASVIAVQF FVERKQLFSF SKDKVLRLWD IQHQLSIQRI ACSFPKSQDF RCLFHFDEAH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAACAGATG AAACAAACAA CTCCACATTG CTGGGAAGGT GGCATTCAGA GTCAAGTACT 60
TCATTGGTAG GGAAACTCTG CAGCTTTGTC ATCTAACTCT TCCAGACAAG AAAGTGGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

KEGG

hsa:151790

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002386	Ailuropoda melanoleuca	84.56	0.00e+00	926.00
IUUC-Aca-005140	Anolis carolinensis	54.43	0.00e+00	722.00
IUUC-Ame-011677	Astyanax mexicanus	57.25	2.00e-121	429.00
IUUC-Bta-013449	Bos taurus	80.65	0.00e+00	1167.00
IUUC-Cja-019381	Callithrix jacchus	90.97	0.00e+00	1310.00
IUUC-Cfa-020449	Canis familiaris	79.80	0.00e+00	1122.00
IUUC-Csa-023219	Chlorocebus sabaeus	95.64	0.00e+00	969.00
IUUC-Cho-024437	Choloepus hoffmanni	94.47	1.00e-120	427.00
IUUC-Cin-025263	Ciona intestinalis	41.98	5.00e-159	555.00
IUUC-Csv-026326	Ciona savignyi	25.56	5.00e-42	165.00
IUUC-Dno-029512	Dasypus novemcinctus	79.37	0.00e+00	1103.00
IUUC-Dor-030182	Dipodomys ordii	69.23	0.00e+00	973.00
IUUC-Ete-033152	Echinops telfairi	76.01	0.00e+00	1057.00
IUUC-Eca-033848	Equus caballus	72.32	7.00e-159	553.00
IUUC-Eeu-034535	Erinaceus europaeus	65.24	0.00e+00	806.00
IUUC-Fca-036363	Felis catus	87.02	0.00e+00	943.00
IUUC-Gmo-039551	Gadus morhua	32.58	5.00e-35	142.00
IUUC-Gac-041482	Gasterosteus aculeatus	24.66	6.00e-40	158.00
IUUC-Ggo-045225	Gorilla gorilla	98.13	0.00e+00	1403.00
IUUC-Itr-047862	Ictidomys tridecemlineatus	82.02	0.00e+00	829.00
IUUC-Lch-049722	Latimeria chalumnae	53.28	0.00e+00	744.00
IUUC-Loc-052665	Lepisosteus oculatus	51.61	0.00e+00	725.00
IUUC-Laf-054050	Loxodonta africana	79.16	0.00e+00	1003.00
IUUC-Meu-056792	Macropus eugenii	63.90	0.00e+00	652.00
IUUC-Mmr-060714	Microcebus murinus	94.51	2.00e-91	329.00
IUUC-Mdo-062938	Monodelphis domestica	65.67	0.00e+00	917.00
IUUC-Mmu-063645	Mus musculus	75.96	0.00e+00	1106.00
IUUC-Mpu-066015	Mustela putorius furo	78.93	0.00e+00	1149.00
IUUC-Mlu-068140	Myotis lucifugus	80.61	0.00e+00	1084.00
IUUC-Nle-069533	Nomascus leucogenys	96.54	0.00e+00	1334.00
IUUC-Opr-070439	Ochotona princeps	63.87	0.00e+00	902.00
IUUC-Oan-073400	Ornithorhynchus anatinus	56.69	1.00e-95	342.00
IUUC-Ocu-074202	Oryctolagus cuniculus	93.12	3.00e-121	429.00
IUUC-Ola-086449	Oryzias latipes	25.90	5.00e-34	139.00
IUUC-Oga-087999	Otolemur garnettii	73.23	0.00e+00	792.00
IUUC-Oar-090438	Ovis aries	80.65	0.00e+00	1164.00
IUUC-Ptr-090859	Pan troglodytes	98.71	0.00e+00	1369.00
IUUC-Pan-092049	Papio anubis	95.40	0.00e+00	879.00
IUUC-Psi-093625	Pelodiscus sinensis	60.70	0.00e+00	852.00
IUUC-Pma-094599	Petromyzon marinus	28.12	7.00e-55	208.00
IUUC-Pfo-096408	Poecilia formosa	24.59	1.00e-43	171.00
IUUC-Pab-098444	Pongo abelii	97.56	0.00e+00	918.00
IUUC-Pca-100464	Procavia capensis	71.19	0.00e+00	665.00
IUUC-Pva-102863	Pteropus vampyrus	80.09	0.00e+00	1154.00
IUUC-Rno-105493	Rattus norvegicus	74.22	0.00e+00	1068.00
IUUC-Sha-107206	Sarcophilus harrisii	61.24	0.00e+00	832.00
IUUC-Sar-113119	Sorex araneus	64.07	0.00e+00	748.00
IUUC-Ssc-116181	Sus scrofa	85.52	0.00e+00	940.00
IUUC-Tru-117666	Takifugu rubripes	26.12	3.00e-39	156.00
IUUC-Tsy-119608	Tarsius syrichta	71.45	0.00e+00	1001.00
IUUC-Tni-120461	Tetraodon nigroviridis	43.20	9.00e-26	111.00
IUUC-Tbe-127509	Tupaia belangeri	71.69	0.00e+00	983.00
IUUC-Ttr-128571	Tursiops truncatus	82.67	0.00e+00	778.00
IUUC-Vpa-130340	Vicugna pacos	77.29	0.00e+00	1106.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence