iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000013291.3	ENSSSCT00000033074.1	ENSSSCP00000029003.1
ENSSSCG00000013291.3	ENSSSCT00000036409.1	ENSSSCP00000030366.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.30e-07	29.9	67	128

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 67   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 128
           5689*****************************999999*****************999977 PP

Organism

Sus scrofa

Functional Description
(View)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Protein Sequence
(Fasta)

MSLLHCENSC GSSQSESDCC AAMAASSCGA AAKDDGVSGT ASTGNLSSSF MEEIQGYDVE 60
FDPPLESKYE CPICLMALRE AVQTPCGHRF CKACIIKSIR DAGHKCPVDN EILLENQLFP 120

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Nucleotide Sequence
(Fasta)

CTCGGCCGCT CTGTCTCCTC CCCGGCCAGC TCCCCGCCCC TCGCTCCCTG GGGCAAGCAG 60
AAAAGGCGGA AGTGGGAACG TCCACTGCTG GGGCTCGGTC TCCGGGCGGA CGAGGGAACT 120

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Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0391--Immunity
KW-1017--Isopeptide bond
KW-0551--Lipid droplet
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0987--Osteopetrosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

ssc:396629

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	93.36	0.00e+00	991.00
IUUC-Apl-004062	Anas platyrhynchos	74.77	0.00e+00	849.00
IUUC-Aca-004636	Anolis carolinensis	71.66	0.00e+00	778.00
IUUC-Ame-011682	Astyanax mexicanus	56.10	2.00e-168	585.00
IUUC-Bta-012692	Bos taurus	93.53	0.00e+00	1009.00
IUUC-Cja-019426	Callithrix jacchus	88.91	0.00e+00	966.00
IUUC-Cfa-020948	Canis familiaris	91.84	0.00e+00	868.00
IUUC-Cpo-021378	Cavia porcellus	90.44	0.00e+00	984.00
IUUC-Csa-024045	Chlorocebus sabaeus	89.09	0.00e+00	972.00
IUUC-Cho-024973	Choloepus hoffmanni	76.28	6.00e-108	384.00
IUUC-Csv-026300	Ciona savignyi	41.59	1.00e-46	179.00
IUUC-Dre-027557	Danio rerio	58.61	3.00e-178	617.00
IUUC-Dno-030032	Dasypus novemcinctus	89.91	7.00e-153	532.00
IUUC-Dor-030790	Dipodomys ordii	88.38	0.00e+00	958.00
IUUC-Dme-031921	Drosophila melanogaster	27.35	6.00e-42	164.00
IUUC-Ete-032952	Echinops telfairi	82.60	7.00e-165	573.00
IUUC-Eca-033924	Equus caballus	88.79	0.00e+00	916.00
IUUC-Eeu-034734	Erinaceus europaeus	82.66	0.00e+00	868.00
IUUC-Fca-036222	Felis catus	84.69	0.00e+00	867.00
IUUC-Fal-036834	Ficedula albicollis	76.38	0.00e+00	752.00
IUUC-Fox-037935	Fusarium oxysporum	29.77	4.00e-22	99.00
IUUC-Gmo-039061	Gadus morhua	60.38	3.00e-89	322.00
IUUC-Ggr-040084	Gaeumannomyces graminis	27.93	3.00e-12	66.60
IUUC-Gga-040599	Gallus gallus	75.09	0.00e+00	853.00
IUUC-Gac-041977	Gasterosteus aculeatus	53.99	2.00e-171	595.00
IUUC-Ggo-044508	Gorilla gorilla	83.43	0.00e+00	889.00
IUUC-Hsa-046349	Homo sapiens	89.83	0.00e+00	1004.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	89.85	0.00e+00	983.00
IUUC-Lch-049821	Latimeria chalumnae	68.52	0.00e+00	761.00
IUUC-Loc-051995	Lepisosteus oculatus	61.81	0.00e+00	642.00
IUUC-Laf-054115	Loxodonta africana	86.90	0.00e+00	970.00
IUUC-Mcc-055298	Macaca mulatta	88.72	0.00e+00	967.00
IUUC-Mor-057263	Magnaporthe oryzae	29.63	2.00e-16	80.10
IUUC-Mpo-057517	Magnaporthe poae	28.85	6.00e-14	72.00
IUUC-Mga-059340	Meleagris gallopavo	74.73	0.00e+00	830.00
IUUC-Mvi-060553	Microbotryum violaceum	26.79	8.00e-15	74.70
IUUC-Mmr-061063	Microcebus murinus	90.76	0.00e+00	967.00
IUUC-Mdo-062075	Monodelphis domestica	81.03	0.00e+00	917.00
IUUC-Mmu-063780	Mus musculus	86.72	0.00e+00	909.00
IUUC-Mac-064529	Musa acuminata	25.43	4.00e-10	58.50
IUUC-Mpu-065748	Mustela putorius furo	93.16	0.00e+00	991.00
IUUC-Mlu-067888	Myotis lucifugus	89.09	0.00e+00	965.00
IUUC-Ncr-068632	Neurospora crassa	28.50	2.00e-17	83.60
IUUC-Nle-069234	Nomascus leucogenys	89.28	0.00e+00	978.00
IUUC-Opr-070393	Ochotona princeps	96.71	1.00e-123	436.00
IUUC-Ont-072459	Oreochromis niloticus	55.30	4.00e-180	624.00
IUUC-Oan-073578	Ornithorhynchus anatinus	82.75	0.00e+00	919.00
IUUC-Ocu-074201	Oryctolagus cuniculus	90.94	0.00e+00	991.00
IUUC-Ola-087319	Oryzias latipes	64.26	4.00e-90	325.00
IUUC-Olu-087748	Ostreococcus lucimarinus	22.73	6.00e-11	61.20
IUUC-Oga-087936	Otolemur garnettii	89.65	0.00e+00	980.00
IUUC-Oar-089379	Ovis aries	92.79	0.00e+00	1012.00
IUUC-Ptr-090758	Pan troglodytes	89.65	0.00e+00	977.00
IUUC-Pan-092590	Papio anubis	88.91	0.00e+00	968.00
IUUC-Psi-093948	Pelodiscus sinensis	73.31	0.00e+00	819.00
IUUC-Pma-094434	Petromyzon marinus	43.92	9.00e-129	453.00
IUUC-Pfo-096912	Poecilia formosa	53.53	1.00e-171	595.00
IUUC-Pab-097651	Pongo abelii	89.65	0.00e+00	979.00
IUUC-Pca-100958	Procavia capensis	85.20	0.00e+00	706.00
IUUC-Pva-103247	Pteropus vampyrus	92.89	6.00e-132	464.00
IUUC-Pte-104279	Pyrenophora teres	26.48	5.00e-13	69.30
IUUC-Rno-104994	Rattus norvegicus	85.42	0.00e+00	919.00
IUUC-Sha-106494	Sarcophilus harrisii	81.55	0.00e+00	918.00
IUUC-Sar-113375	Sorex araneus	86.56	0.00e+00	931.00
IUUC-Sre-115218	Sporisorium reilianum	26.32	5.00e-15	76.30
IUUC-Tgu-117232	Taeniopygia guttata	73.76	0.00e+00	804.00
IUUC-Tru-118321	Takifugu rubripes	55.93	4.00e-170	590.00
IUUC-Tni-120475	Tetraodon nigroviridis	55.17	1.00e-166	579.00
IUUC-Tbe-127719	Tupaia belangeri	77.76	0.00e+00	820.00
IUUC-Ttr-129264	Tursiops truncatus	96.44	9.00e-132	463.00
IUUC-Uma-129620	Ustilago maydis	26.19	3.00e-17	83.60
IUUC-Vpa-130244	Vicugna pacos	95.26	7.00e-135	473.00
IUUC-Xtr-131948	Xenopus tropicalis	65.95	0.00e+00	747.00
IUUC-Xma-133132	Xiphophorus maculatus	58.00	4.00e-174	604.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence