iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Information
GWAS Central
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20657603

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.2	13.9	69	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 13   lvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           ++ pC+H+f+ +C + +      + +   CP Cr
   Q: 69   RIIPCKHAFCYHCANLY-----DKVGYKVCPRCR 97
           579**********9888.....577888899997 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.

Protein Sequence
(Fasta)

MNKMPAGEQE CEYNKEGKYY SKGVKLVRKK KKIPGYRWGD IKINIIGEKD DLPIHFCDKC 60
DLPIKIYGRI IPCKHAFCYH CANLYDKVGY KVCPRCRYPV LRIEAHKRGS VFMCSIVQQC 120

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Nucleotide Sequence
(Fasta)

TTTTTGAGGA AGTAGACAAA CCTAAATATG TGTCTGAACT CCAAGGAATA TGAACAAGAT 60
GCCTGCTGGT GAACAAGAAT GTGAATATAA CAAAGAAGGG AAGTACTACT CTAAAGGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013087--Znf_C2H2_type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50157--ZINC_FINGER_C2H2_2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030155--P:regulation of cell adhesion

KEGG

hsa:158506

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cre-022922	Chlamydomonas reinhardtii	30.23	4.00e-07	49.70
IUUC-Ggo-045198	Gorilla gorilla	96.95	0.00e+00	687.00
IUUC-Mcc-054964	Macaca mulatta	85.82	7.00e-167	580.00
IUUC-Nle-069265	Nomascus leucogenys	89.56	0.00e+00	657.00
IUUC-Ptr-090608	Pan troglodytes	96.19	0.00e+00	709.00
IUUC-Pan-092342	Papio anubis	84.10	3.00e-169	588.00
IUUC-Pab-098143	Pongo abelii	90.91	0.00e+00	626.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence