iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
circRNADb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	24344130

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.80e-05	26.4	10	76
E3 activity/RING/RING	4.00e-06	28.9	14	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl...asggk....tcPvtrqplteedlvPnltlrrliq 66
           +e+ Cp+ l+l+  Pv++++G+++ r+++ +     a         cP +++p++++ l  nl l rl++
   Q: 10   QELSCPLCLQLFDAPVTAECGHSFCRACLGRVAgepA---AdgtvLCPCCQAPTRPQALSTNLQLARLVE 76
           7899***************************765553...144479****************99988765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ f+  p++  CgH f++ Cl ++      + ++ +CP C+
   Q: 14   CPLCLQLFDA-PVTAECGHSFCRACLGRV-AGEPAADGTVLCPCCQ 57
           ********99.999***************.5555799999*****7 PP

Organism

Homo sapiens

Functional Description
(View)

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

Protein Sequence
(Fasta)

MSAAPGLLHQ ELSCPLCLQL FDAPVTAECG HSFCRACLGR VAGEPAADGT VLCPCCQAPT 60
RPQALSTNLQ LARLVEGLAQ VPQGHCEEHL DPLSIYCEQD RALVCGVCAS LGSHRGHRLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTAGAACG GTTTCCGGAA GTGATGGGAG GGATTGGGCA GGGCAGCTAA ATATAGTCCT 60
GGGGCCATGG CTCAGTCTGG GAGGGTCTTC CGCTGAGCAC TGTGTGCCCA TCACGCGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-1015--Disulfide bond
KW-0268--Exocytosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0702--S-nitrosylation
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0042383--C:sarcolemma
GO:0001786--F:phosphatidylserine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006887--P:exocytosis
GO:0006936--P:muscle contraction
GO:0007517--P:muscle organ development
GO:0003012--P:muscle system process
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0043569--P:negative regulation of insulin-like growth factor receptor signaling pathway
GO:0010832--P:negative regulation of myotube differentiation
GO:0001778--P:plasma membrane repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization

KEGG

hsa:493829

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002377	Ailuropoda melanoleuca	75.93	0.00e+00	656.00
IUUC-Aca-004755	Anolis carolinensis	64.16	3.00e-174	604.00
IUUC-Bta-013476	Bos taurus	77.80	0.00e+00	729.00
IUUC-Cja-018969	Callithrix jacchus	86.57	0.00e+00	767.00
IUUC-Cfa-020155	Canis familiaris	93.50	0.00e+00	869.00
IUUC-Cpo-021646	Cavia porcellus	89.52	0.00e+00	835.00
IUUC-Cre-022560	Chlamydomonas reinhardtii	44.90	1.00e-05	45.40
IUUC-Csa-023855	Chlorocebus sabaeus	97.92	0.00e+00	634.00
IUUC-Dno-029142	Dasypus novemcinctus	92.03	0.00e+00	785.00
IUUC-Dor-030394	Dipodomys ordii	70.09	3.00e-89	322.00
IUUC-Ete-032801	Echinops telfairi	84.62	3.00e-64	239.00
IUUC-Eca-034378	Equus caballus	94.13	0.00e+00	860.00
IUUC-Eeu-034526	Erinaceus europaeus	85.14	0.00e+00	748.00
IUUC-Fca-036440	Felis catus	93.71	0.00e+00	884.00
IUUC-Ggo-045086	Gorilla gorilla	100.00	0.00e+00	717.00
IUUC-Itr-048959	Ictidomys tridecemlineatus	93.29	0.00e+00	875.00
IUUC-Laf-054479	Loxodonta africana	93.08	0.00e+00	867.00
IUUC-Mcc-055814	Macaca mulatta	97.08	0.00e+00	860.00
IUUC-Meu-056767	Macropus eugenii	74.68	0.00e+00	701.00
IUUC-Mmr-061616	Microcebus murinus	94.55	0.00e+00	882.00
IUUC-Mdo-062252	Monodelphis domestica	77.45	0.00e+00	734.00
IUUC-Mmu-063094	Mus musculus	91.19	0.00e+00	839.00
IUUC-Mpu-065885	Mustela putorius furo	78.41	0.00e+00	671.00
IUUC-Mlu-068150	Myotis lucifugus	64.81	2.00e-84	305.00
IUUC-Nle-069476	Nomascus leucogenys	99.37	0.00e+00	892.00
IUUC-Opr-070871	Ochotona princeps	92.79	2.00e-144	505.00
IUUC-Oan-072738	Ornithorhynchus anatinus	77.59	0.00e+00	723.00
IUUC-Ocu-074132	Oryctolagus cuniculus	95.04	0.00e+00	662.00
IUUC-Oga-088268	Otolemur garnettii	65.06	3.00e-150	525.00
IUUC-Oar-089555	Ovis aries	71.97	2.00e-169	588.00
IUUC-Ptr-090792	Pan troglodytes	100.00	0.00e+00	902.00
IUUC-Pan-092897	Papio anubis	98.74	0.00e+00	890.00
IUUC-Pab-098716	Pongo abelii	99.58	0.00e+00	898.00
IUUC-Pca-100618	Procavia capensis	83.65	0.00e+00	771.00
IUUC-Pva-102430	Pteropus vampyrus	84.28	0.00e+00	765.00
IUUC-Rno-105665	Rattus norvegicus	90.78	0.00e+00	863.00
IUUC-Sha-106854	Sarcophilus harrisii	65.83	2.00e-175	608.00
IUUC-Sar-113028	Sorex araneus	90.29	2.00e-145	508.00
IUUC-Ssc-116124	Sus scrofa	93.93	0.00e+00	850.00
IUUC-Tbe-127273	Tupaia belangeri	90.21	3.00e-123	435.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence