iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.20e-06	27.8	10	76
E3 activity/RING/RING	4.70e-06	28.2	14	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl...asggk....tcPvtrqplteedlvPnltlrrliq 66
           +e+ Cp+ l+l+  Pv++++G+++ r+++ +     a         cP +++p++++ l  nl l rl++
   Q: 10   QELSCPLCLQLFDAPVTAECGHSFCRACLIRVAgepA---AdgtvACPCCQAPTRPQALSTNLQLSRLVE 76
           6899*************************99665552...14557******************9988875 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ f+  p++  CgH f++ Cl ++      + ++  CP C+
   Q: 14   CPLCLQLFDA-PVTAECGHSFCRACLIRV-AGEPAADGTVACPCCQ 57
           ********99.999************999.5555799999*****7 PP

Organism

Mus musculus

Functional Description
(View)

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.

Protein Sequence
(Fasta)

MSAAPGLLRQ ELSCPLCLQL FDAPVTAECG HSFCRACLIR VAGEPAADGT VACPCCQAPT 60
RPQALSTNLQ LSRLVEGLAQ VPQGHCEEHL DPLSIYCEQD RTLVCGVCAS LGSHRGHRLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGAGCCTG CTGCTTGCTT CTTGCTTGTC TTGGACACAA CTCCGATCAC CCTGCTGTTA 60
GACCTGAACC TGACTGGTCC TCCTGGGAGT CTTTTTTGGC CTAAGTTCTC CCACCAGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-1015--Disulfide bond
KW-0268--Exocytosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0702--S-nitrosylation
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0042383--C:sarcolemma
GO:0001786--F:phosphatidylserine binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006887--P:exocytosis
GO:0006900--P:membrane budding
GO:0006936--P:muscle contraction
GO:0007517--P:muscle organ development
GO:0003012--P:muscle system process
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0043569--P:negative regulation of insulin-like growth factor receptor signaling pathway
GO:0010832--P:negative regulation of myotube differentiation
GO:0001778--P:plasma membrane repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization

KEGG

mmu:434246

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002377	Ailuropoda melanoleuca	73.03	0.00e+00	660.00
IUUC-Aca-004755	Anolis carolinensis	61.62	7.00e-169	586.00
IUUC-Bta-013476	Bos taurus	76.78	0.00e+00	704.00
IUUC-Cja-018969	Callithrix jacchus	79.96	0.00e+00	740.00
IUUC-Cfa-020155	Canis familiaris	89.94	0.00e+00	848.00
IUUC-Cpo-021646	Cavia porcellus	87.63	0.00e+00	827.00
IUUC-Csa-023855	Chlorocebus sabaeus	88.99	1.00e-169	589.00
IUUC-Dno-029142	Dasypus novemcinctus	87.21	0.00e+00	760.00
IUUC-Dor-030394	Dipodomys ordii	67.09	4.00e-86	311.00
IUUC-Ete-032801	Echinops telfairi	82.81	3.00e-62	232.00
IUUC-Eca-034378	Equus caballus	90.15	0.00e+00	852.00
IUUC-Eeu-034526	Erinaceus europaeus	82.18	0.00e+00	743.00
IUUC-Fca-036440	Felis catus	90.36	0.00e+00	880.00
IUUC-Ggo-045086	Gorilla gorilla	93.28	0.00e+00	676.00
IUUC-Hsa-046533	Homo sapiens	91.19	0.00e+00	833.00
IUUC-Itr-048959	Ictidomys tridecemlineatus	91.19	0.00e+00	865.00
IUUC-Laf-054479	Loxodonta africana	89.10	0.00e+00	841.00
IUUC-Mcc-055814	Macaca mulatta	89.35	0.00e+00	803.00
IUUC-Meu-056767	Macropus eugenii	71.55	0.00e+00	681.00
IUUC-Mmr-061616	Microcebus murinus	89.10	0.00e+00	845.00
IUUC-Mdo-062252	Monodelphis domestica	74.53	0.00e+00	717.00
IUUC-Mpu-065885	Mustela putorius furo	75.68	0.00e+00	657.00
IUUC-Mlu-068150	Myotis lucifugus	93.70	2.00e-66	245.00
IUUC-Nle-069476	Nomascus leucogenys	91.42	0.00e+00	832.00
IUUC-Opr-070871	Ochotona princeps	89.97	4.00e-142	498.00
IUUC-Oan-072738	Ornithorhynchus anatinus	73.58	0.00e+00	706.00
IUUC-Ocu-074132	Oryctolagus cuniculus	91.58	0.00e+00	651.00
IUUC-Olu-087666	Ostreococcus lucimarinus	41.89	2.00e-11	63.90
IUUC-Oga-088268	Otolemur garnettii	62.34	3.00e-146	511.00
IUUC-Oar-089555	Ovis aries	68.15	1.00e-168	586.00
IUUC-Ptr-090792	Pan troglodytes	91.19	0.00e+00	833.00
IUUC-Pan-092897	Papio anubis	91.19	0.00e+00	834.00
IUUC-Pab-098716	Pongo abelii	91.19	0.00e+00	833.00
IUUC-Pca-100618	Procavia capensis	81.34	0.00e+00	757.00
IUUC-Pva-102430	Pteropus vampyrus	80.71	0.00e+00	742.00
IUUC-Rno-105665	Rattus norvegicus	95.39	0.00e+00	929.00
IUUC-Sha-106854	Sarcophilus harrisii	62.86	6.00e-171	593.00
IUUC-Sar-113028	Sorex araneus	85.00	2.00e-144	504.00
IUUC-Ssc-116124	Sus scrofa	89.85	0.00e+00	820.00
IUUC-Tbe-127273	Tupaia belangeri	86.44	1.00e-120	426.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence