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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046132
UUCD1 version UUC-HoS-01047
Ensembl Protein ID ENSP00000426387.1
UniProt Accession Q8NAP3; D3DNF6; ZBT38_HUMAN
Genbank Protein ID EAW79004.1; EAW79005.1; BAC03868.1
Protein Name Zinc finger and BTB domain-containing protein 38
Genbank Nucleotide ID AC010184; CH471052; AK092355
Gene Name ZBTB38
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000177311.11 ENST00000514251.5 ENSP00000426387.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 8.60e-12 46.9 33 97
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv+++v++++f+ah  vLaasS +F++ f ++    s  +   e++d+++evf ++l+++Y++++ 
   Q: 33   CDVTIIVEDTKFKAHSNVLAASSLYFKNIFwSHTICIS--SHVLELDDLKAEVFTEILNYIYSSTVV 97
           9*****************************76666644..67********************99876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).
 Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).
Protein Sequence
(Fasta)
MTVMSLSRDL KDDFHSDTVL SILNEQRIRG ILCDVTIIVE DTKFKAHSNV LAASSLYFKN 60
IFWSHTICIS SHVLELDDLK AEVFTEILNY IYSSTVVVKR QETVTDLAAA GKKLGISFLE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046132|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACAGAAGCC CTCTAGCCAA GGCCTCGGGC AGCCCTACCA AATGAATATG GGCACTTGAG 60
TTTTCTAGGA GGGCTTTCCT GCTGCCCTGG GTCTCATCCA ACTGGTATCC ATCTAAACAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046132|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0072562--C:blood microparticle
GO:0005694--C:chromosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0008327--F:methyl-CpG binding
GO:0042803--F:protein homodimerization activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006275--P:regulation of DNA replication
GO:0006351--P:transcription, DNA-templated
KEGG hsa:253461
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001652 Ailuropoda melanoleuca 91.63 0.00e+00 2222.00
IUUC-Apl-003223 Anas platyrhynchos 74.79 5.00e-108 385.00
IUUC-Aca-005028 Anolis carolinensis 56.53 0.00e+00 1220.00
IUUC-Ame-011804 Astyanax mexicanus 43.13 9.00e-117 415.00
IUUC-Bta-013494 Bos taurus 88.21 0.00e+00 2112.00
IUUC-Cja-019710 Callithrix jacchus 96.40 0.00e+00 2387.00
IUUC-Cfa-021032 Canis familiaris 89.04 0.00e+00 2167.00
IUUC-Cpo-022360 Cavia porcellus 88.57 7.00e-133 468.00
IUUC-Csa-023953 Chlorocebus sabaeus 98.83 0.00e+00 2440.00
IUUC-Dre-027649 Danio rerio 50.52 1.00e-75 278.00
IUUC-Dno-029387 Dasypus novemcinctus 88.14 0.00e+00 2095.00
IUUC-Dor-030735 Dipodomys ordii 68.81 0.00e+00 1452.00
IUUC-Eca-033215 Equus caballus 94.70 0.00e+00 1059.00
IUUC-Eeu-034575 Erinaceus europaeus 81.02 0.00e+00 1912.00
IUUC-Fca-035509 Felis catus 91.21 0.00e+00 2238.00
IUUC-Fal-037430 Ficedula albicollis 63.52 0.00e+00 1402.00
IUUC-Gmo-039316 Gadus morhua 41.76 3.00e-102 366.00
IUUC-Gga-040476 Gallus gallus 64.18 0.00e+00 1442.00
IUUC-Gac-042333 Gasterosteus aculeatus 33.51 1.00e-132 467.00
IUUC-Ggo-044539 Gorilla gorilla 99.67 0.00e+00 2408.00
IUUC-Itr-049051 Ictidomys tridecemlineatus 90.12 0.00e+00 2231.00
IUUC-Lch-049515 Latimeria chalumnae 45.79 0.00e+00 915.00
IUUC-Loc-052352 Lepisosteus oculatus 37.58 3.00e-145 509.00
IUUC-Mcc-055465 Macaca mulatta 98.58 0.00e+00 2415.00
IUUC-Mmr-060586 Microcebus murinus 93.72 0.00e+00 2323.00
IUUC-Mdo-062957 Monodelphis domestica 68.54 0.00e+00 1519.00
IUUC-Mmu-064052 Mus musculus 81.08 0.00e+00 1871.00
IUUC-Mpu-066182 Mustela putorius furo 89.54 0.00e+00 2177.00
IUUC-Mlu-067923 Myotis lucifugus 84.97 0.00e+00 1982.00
IUUC-Nle-069474 Nomascus leucogenys 98.91 0.00e+00 2446.00
IUUC-Opr-070268 Ochotona princeps 78.60 0.00e+00 1853.00
IUUC-Ont-072442 Oreochromis niloticus 33.11 9.00e-131 461.00
IUUC-Oan-073227 Ornithorhynchus anatinus 65.61 8.00e-95 341.00
IUUC-Ocu-074402 Oryctolagus cuniculus 52.22 0.00e+00 656.00
IUUC-Ola-087519 Oryzias latipes 40.25 4.00e-88 318.00
IUUC-Oga-088893 Otolemur garnettii 89.46 0.00e+00 2128.00
IUUC-Oar-089859 Ovis aries 88.11 0.00e+00 2112.00
IUUC-Ptr-091526 Pan troglodytes 99.41 0.00e+00 2399.00
IUUC-Pan-091689 Papio anubis 98.83 0.00e+00 2421.00
IUUC-Psi-093228 Pelodiscus sinensis 65.70 0.00e+00 1468.00
IUUC-Pfo-096927 Poecilia formosa 34.03 1.00e-129 457.00
IUUC-Pca-101078 Procavia capensis 83.88 0.00e+00 1179.00
IUUC-Pva-102635 Pteropus vampyrus 91.38 0.00e+00 2192.00
IUUC-Rno-105953 Rattus norvegicus 80.30 0.00e+00 1862.00
IUUC-Sha-107421 Sarcophilus harrisii 65.14 0.00e+00 1357.00
IUUC-Ssc-116175 Sus scrofa 88.27 0.00e+00 2103.00
IUUC-Tgu-116566 Taeniopygia guttata 63.43 0.00e+00 1370.00
IUUC-Tsy-119041 Tarsius syrichta 91.71 0.00e+00 2239.00
IUUC-Xtr-132706 Xenopus tropicalis 42.52 0.00e+00 778.00
Created Date 25-Jun-2017

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