iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000030707.2	ENSCAFT00000049589.2	ENSCAFP00000040255.1
ENSCAFG00000030707.2	ENSCAFT00000043652.1	ENSCAFP00000041117.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.60e-39	135.2	9	144

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkee 89
           l+++++el++++ +gi+a pv+e dl+ew + i+G ++t ++g +F+l+i+f+++Y+f PP vkf+t  fhPnv++n G+vC+++l+++
   Q: 9    LERDFQELKENNFKGITAFPVSE-DLMEWGANIEGLQNTFWHGLFFQLTIHFTSQYNFVPPVVKFITIPFHPNVDQNsGRVCIDFLDDP 96
           679********************.9**************************************************************** PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           ekW++ ++++s+ll++q +l++p  e+p+n eaa++l k+++ yk++v
   Q: 97   EKWNTNYTLSSILLALQVMLSNPVLENPVNLEAAQMLIKDESLYKQIV 144
           *********************************************987 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MHCRAYFLLE RDFQELKENN FKGITAFPVS EDLMEWGANI EGLQNTFWHG LFFQLTIHFT 60
SQYNFVPPVV KFITIPFHPN VDQNSGRVCI DFLDDPEKWN TNYTLSSILL ALQVMLSNPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCACTGCA GAGCTTACTT CTTGCTGGAG AGAGACTTCC AAGAGTTGAA GGAGAACAAT 60
TTTAAGGTGA GTGTGGGAAC CTGGAGAGGT GTGTTTTGTT GGGAGTACGA GTTTTTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0016574--P:histone ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002211	Ailuropoda melanoleuca	83.25	1.00e-92	331.00
IUUC-Aca-004682	Anolis carolinensis	45.19	8.00e-50	189.00
IUUC-Bta-013054	Bos taurus	67.10	8.00e-90	323.00
IUUC-Cja-018784	Callithrix jacchus	66.81	8.00e-85	306.00
IUUC-Cpo-022462	Cavia porcellus	58.86	9.00e-59	219.00
IUUC-Csa-023486	Chlorocebus sabaeus	70.04	4.00e-91	327.00
IUUC-Cho-024685	Choloepus hoffmanni	51.79	5.00e-48	184.00
IUUC-Dno-029061	Dasypus novemcinctus	71.43	1.00e-86	312.00
IUUC-Ete-032233	Echinops telfairi	49.78	2.00e-60	224.00
IUUC-Eca-033400	Equus caballus	79.35	1.00e-57	215.00
IUUC-Fca-035778	Felis catus	81.06	9.00e-107	379.00
IUUC-Ggo-044718	Gorilla gorilla	71.81	1.00e-92	332.00
IUUC-Hsa-046798	Homo sapiens	72.25	1.00e-93	336.00
IUUC-Lch-050337	Latimeria chalumnae	45.80	2.00e-55	209.00
IUUC-Loc-051819	Lepisosteus oculatus	45.71	3.00e-50	191.00
IUUC-Laf-054536	Loxodonta africana	67.54	2.00e-88	318.00
IUUC-Mcc-055028	Macaca mulatta	70.04	1.00e-91	329.00
IUUC-Mmr-061623	Microcebus murinus	65.20	9.00e-75	273.00
IUUC-Mdo-062614	Monodelphis domestica	44.73	1.00e-52	199.00
IUUC-Mmu-063194	Mus musculus	52.86	5.00e-62	231.00
IUUC-Mpu-066467	Mustela putorius furo	81.50	1.00e-100	359.00
IUUC-Mlu-067976	Myotis lucifugus	64.16	2.00e-78	285.00
IUUC-Nle-069407	Nomascus leucogenys	67.11	1.00e-87	316.00
IUUC-Opr-070526	Ochotona princeps	61.49	9.00e-51	192.00
IUUC-Oan-073005	Ornithorhynchus anatinus	50.00	1.00e-47	182.00
IUUC-Ocu-074953	Oryctolagus cuniculus	63.00	6.00e-77	280.00
IUUC-Oga-089061	Otolemur garnettii	70.04	7.00e-93	333.00
IUUC-Oar-090147	Ovis aries	65.49	2.00e-83	302.00
IUUC-Ptr-090873	Pan troglodytes	71.68	2.00e-92	331.00
IUUC-Pan-091873	Papio anubis	69.16	2.00e-90	324.00
IUUC-Psi-093780	Pelodiscus sinensis	48.82	1.00e-32	133.00
IUUC-Pab-098662	Pongo abelii	72.69	2.00e-94	338.00
IUUC-Pca-100167	Procavia capensis	48.70	6.00e-58	217.00
IUUC-Pva-102119	Pteropus vampyrus	68.18	3.00e-36	145.00
IUUC-Rno-105522	Rattus norvegicus	47.79	2.00e-60	226.00
IUUC-Sar-113070	Sorex araneus	51.22	5.00e-53	200.00
IUUC-Ssc-115890	Sus scrofa	69.60	2.00e-91	328.00
IUUC-Tsy-119341	Tarsius syrichta	62.00	8.00e-68	250.00
IUUC-Tbe-127433	Tupaia belangeri	52.19	3.00e-51	195.00
IUUC-Ttr-128614	Tursiops truncatus	54.13	1.00e-60	226.00
IUUC-Vpa-130777	Vicugna pacos	68.18	5.00e-79	287.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence