iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000177479.19	ENST00000356401.8	ENSP00000348769.4
ENSG00000177479.19	ENST00000452385.5	ENSP00000403845.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RBR	RBR	20226183; 19664228

Classification

Family	E-value	Score	Start	End
E3 activity/RBR	1.10e-55	189.2	139	326

Active Site

Position(s)	Description	Evidence
310	N/A	{ECO:0000305\|PubMed:24076655}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C+vC+ ++  +e++ +l+C+h+fC++C++q++++ +k+g  + +sc+a++cp +++e+ +  ll++eel ++y+++l++++ve++++l++
   Q: 139  CAVCM-QFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQL 227
           9***9.77777888899************************************************************************* PP
   S: 91   cpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnhm 180
           cp +dC +v+++++  ++ +v+c++c+++fC++C++++H++++C +++++l+k++   +++e++++++a++k+CpkC+++iekn+gCnhm
   Q: 228  CPGADCPMVIRVQEP-RARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCA---DDSETANYISAHTKDCPKCNICIEKNGGCNHM 313
           **************7.99*************************************...99****************************** PP
   S: 181  tCakCkaefCwlC 193
           +C+kCk++fCw+C
   Q: 314  QCSKCKHDFCWMC 326
           ************* PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).

Protein Sequence
(Fasta)

MSVDMNSQGS DSNEEDYDPN CEEEEEEEED DPGDIEDYYV GVASDVEQQG ADAFDPEEYQ 60
FTCLTYKESE GALNEHMTSL ASVLKVSHSV AKLILVNFHW QVSEILDRYK SNSAQLLVEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAACGGCGC CAAGCACTTC CGGAGCTGTG GGGACGACTC TTCTGGAGGA AGCAGCGCGG 60
GCTTGACCGG CGTCGGCCCG CCGCCTCCGC TGCCGCTTCG CCCCAATCCG GTCCCTCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0048588--P:developmental cell growth
GO:0071425--P:hematopoietic stem cell proliferation
GO:0007275--P:multicellular organism development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:10425

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001557	Ailuropoda melanoleuca	97.97	0.00e+00	936.00
IUUC-Apl-003878	Anas platyrhynchos	92.90	0.00e+00	875.00
IUUC-Aca-004865	Anolis carolinensis	92.09	0.00e+00	880.00
IUUC-Bta-012901	Bos taurus	97.77	0.00e+00	932.00
IUUC-Bra-017081	Brassica rapa	28.97	1.00e-57	218.00
IUUC-Cel-018334	Caenorhabditis elegans	48.64	7.00e-127	447.00
IUUC-Cja-019728	Callithrix jacchus	98.99	0.00e+00	939.00
IUUC-Cfa-020953	Canis familiaris	98.17	0.00e+00	936.00
IUUC-Cpo-021445	Cavia porcellus	98.38	0.00e+00	937.00
IUUC-Csa-023769	Chlorocebus sabaeus	99.19	0.00e+00	944.00
IUUC-Cho-024650	Choloepus hoffmanni	87.42	0.00e+00	792.00
IUUC-Cin-025577	Ciona intestinalis	54.55	2.00e-143	502.00
IUUC-Csv-025849	Ciona savignyi	55.84	3.00e-120	424.00
IUUC-Dre-028490	Danio rerio	79.44	0.00e+00	777.00
IUUC-Dno-029942	Dasypus novemcinctus	97.97	0.00e+00	933.00
IUUC-Dor-030134	Dipodomys ordii	84.98	8.00e-151	526.00
IUUC-Dme-031853	Drosophila melanogaster	55.06	3.00e-149	521.00
IUUC-Ete-032355	Echinops telfairi	89.27	0.00e+00	835.00
IUUC-Eca-033440	Equus caballus	98.17	0.00e+00	937.00
IUUC-Eeu-035230	Erinaceus europaeus	89.36	3.00e-115	408.00
IUUC-Fca-036308	Felis catus	91.90	0.00e+00	867.00
IUUC-Fal-036974	Ficedula albicollis	92.90	0.00e+00	875.00
IUUC-Gmo-038642	Gadus morhua	81.11	0.00e+00	783.00
IUUC-Gga-041019	Gallus gallus	92.90	0.00e+00	875.00
IUUC-Gac-042014	Gasterosteus aculeatus	80.28	0.00e+00	803.00
IUUC-Ggo-045329	Gorilla gorilla	99.59	0.00e+00	946.00
IUUC-Itr-048370	Ictidomys tridecemlineatus	99.04	0.00e+00	844.00
IUUC-Lch-049584	Latimeria chalumnae	85.43	0.00e+00	824.00
IUUC-Loc-051826	Lepisosteus oculatus	80.16	3.00e-167	581.00
IUUC-Laf-054567	Loxodonta africana	96.96	0.00e+00	931.00
IUUC-Mcc-054919	Macaca mulatta	99.19	0.00e+00	944.00
IUUC-Meu-056332	Macropus eugenii	90.87	0.00e+00	849.00
IUUC-Mga-060132	Meleagris gallopavo	92.93	0.00e+00	880.00
IUUC-Mmr-061599	Microcebus murinus	94.74	0.00e+00	886.00
IUUC-Mdo-062186	Monodelphis domestica	94.93	0.00e+00	801.00
IUUC-Mmu-064271	Mus musculus	97.77	0.00e+00	932.00
IUUC-Mpu-066827	Mustela putorius furo	96.67	0.00e+00	828.00
IUUC-Mlu-067528	Myotis lucifugus	96.96	0.00e+00	892.00
IUUC-Nle-068995	Nomascus leucogenys	99.59	0.00e+00	946.00
IUUC-Opr-070518	Ochotona princeps	98.17	0.00e+00	900.00
IUUC-Ont-071650	Oreochromis niloticus	83.27	0.00e+00	822.00
IUUC-Oan-073676	Ornithorhynchus anatinus	93.87	0.00e+00	752.00
IUUC-Ocu-073761	Oryctolagus cuniculus	99.19	0.00e+00	943.00
IUUC-Obr-076705	Oryza brachyantha	30.05	1.00e-58	221.00
IUUC-Ola-087204	Oryzias latipes	79.76	0.00e+00	795.00
IUUC-Oga-088098	Otolemur garnettii	98.38	0.00e+00	933.00
IUUC-Oar-089205	Ovis aries	97.77	0.00e+00	932.00
IUUC-Ptr-091514	Pan troglodytes	99.59	0.00e+00	946.00
IUUC-Pan-092493	Papio anubis	94.43	0.00e+00	899.00
IUUC-Psi-093024	Pelodiscus sinensis	87.50	2.00e-117	414.00
IUUC-Pfo-097256	Poecilia formosa	82.04	0.00e+00	813.00
IUUC-Pab-098504	Pongo abelii	91.89	0.00e+00	845.00
IUUC-Pop-099547	Populus trichocarpa	30.85	2.00e-55	210.00
IUUC-Pca-100700	Procavia capensis	91.08	0.00e+00	836.00
IUUC-Pva-103105	Pteropus vampyrus	97.16	0.00e+00	921.00
IUUC-Rno-105289	Rattus norvegicus	97.97	0.00e+00	932.00
IUUC-Sha-107417	Sarcophilus harrisii	94.93	0.00e+00	871.00
IUUC-Sar-113042	Sorex araneus	95.98	0.00e+00	924.00
IUUC-Ssc-115362	Sus scrofa	98.38	0.00e+00	937.00
IUUC-Tgu-117469	Taeniopygia guttata	92.55	0.00e+00	828.00
IUUC-Tru-117976	Takifugu rubripes	80.39	0.00e+00	816.00
IUUC-Tsy-118876	Tarsius syrichta	85.45	2.00e-95	343.00
IUUC-Tni-119831	Tetraodon nigroviridis	80.39	0.00e+00	793.00
IUUC-Tca-121326	Theobroma cacao	29.14	6.00e-60	225.00
IUUC-Tbe-127386	Tupaia belangeri	91.88	7.00e-161	560.00
IUUC-Ttr-128315	Tursiops truncatus	97.97	0.00e+00	936.00
IUUC-Vpa-130383	Vicugna pacos	90.47	0.00e+00	836.00
IUUC-Xtr-132945	Xenopus tropicalis	90.67	0.00e+00	871.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence