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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045883
Ensembl Protein ID ENSP00000314153.2
UniProt Accession Q86T24; B2R5U6; O00319; Q7Z361; Q8IVP6; Q8N3P0; KAISO_HUMAN
Genbank Protein ID BAG35243.1; CAD38715.1; CAD91170.1; CAD97963.1; CAD98016.1; AAB54087.1; EAX11891.1; AAH42753.1
Protein Name Transcriptional regulator Kaiso; Zinc finger and BTB domain-containing protein 33
Genbank Nucleotide ID AK312321; AL833856; AL833604; BX538016; BX538101; AC002086; CH471107; BC042753
Gene Name ZBTB33; KAISO; ZNF348
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000177485.6 ENST00000326624.2 ENSP00000314153.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteJASPARcircBase
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.20e-10 43.2 32 90
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+++v++++f+ahk +L+asS +F+ lf+        +  ve++ + +e f ++l+++Y++k+
   Q: 32   CDVTVIVEDRKFRAHKNILSASSTYFHQLFSV------AGQVVELSFIRAEIFAEILNYIYSSKI 90
           8*****************************44......478999999**************9986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
 Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
Protein Sequence
(Fasta)
MESRKLISAT DIQYSGSLLN SLNEQRGHGL FCDVTVIVED RKFRAHKNIL SASSTYFHQL 60
FSVAGQVVEL SFIRAEIFAE ILNYIYSSKI VRVRSDLLDE LIKSGQLLGV KFIAELGVPL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045883|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTTTGGCT TCAGCGCTTC GCCCCCGCGC TGTGCCCTCT GTCGGCGGCG TGGGGCAGCT 60
GTAGCAGCGT TGGCGGCAGG AGGCGGCGGC CGCGTCGACG TCGACCCAGA CTGGAGCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045883|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0008327--F:methyl-CpG binding
GO:0043565--F:sequence-specific DNA binding
GO:0035556--P:intracellular signal transduction
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG hsa:10009
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001231 Ailuropoda melanoleuca 92.71 0.00e+00 1195.00
IUUC-Apl-004182 Anas platyrhynchos 64.96 0.00e+00 815.00
IUUC-Aca-005098 Anolis carolinensis 68.15 7.00e-127 447.00
IUUC-Ame-011249 Astyanax mexicanus 44.04 3.00e-82 299.00
IUUC-Bta-013501 Bos taurus 92.56 0.00e+00 1208.00
IUUC-Cja-019946 Callithrix jacchus 98.66 0.00e+00 1301.00
IUUC-Cfa-020364 Canis familiaris 93.30 0.00e+00 1202.00
IUUC-Cpo-021927 Cavia porcellus 91.39 0.00e+00 1201.00
IUUC-Csa-023859 Chlorocebus sabaeus 98.96 0.00e+00 1306.00
IUUC-Cho-024727 Choloepus hoffmanni 88.54 2.00e-124 439.00
IUUC-Dre-028165 Danio rerio 51.42 5.00e-80 292.00
IUUC-Dno-029909 Dasypus novemcinctus 93.75 0.00e+00 1232.00
IUUC-Ete-032594 Echinops telfairi 85.80 0.00e+00 1122.00
IUUC-Eca-034341 Equus caballus 94.20 0.00e+00 1236.00
IUUC-Eeu-034685 Erinaceus europaeus 89.43 0.00e+00 1174.00
IUUC-Fca-036226 Felis catus 93.17 0.00e+00 1111.00
IUUC-Fal-037578 Ficedula albicollis 61.26 0.00e+00 753.00
IUUC-Gmo-038965 Gadus morhua 47.60 1.00e-77 284.00
IUUC-Gga-040745 Gallus gallus 62.85 0.00e+00 750.00
IUUC-Gac-041793 Gasterosteus aculeatus 50.35 3.00e-84 305.00
IUUC-Ggo-044435 Gorilla gorilla 99.55 0.00e+00 1311.00
IUUC-Itr-048497 Ictidomys tridecemlineatus 94.51 0.00e+00 1245.00
IUUC-Lch-050532 Latimeria chalumnae 56.23 0.00e+00 687.00
IUUC-Loc-052122 Lepisosteus oculatus 53.64 2.00e-97 350.00
IUUC-Laf-054186 Loxodonta africana 90.89 0.00e+00 893.00
IUUC-Mcc-054996 Macaca mulatta 99.40 0.00e+00 1311.00
IUUC-Mga-059557 Meleagris gallopavo 60.53 0.00e+00 741.00
IUUC-Mmr-060657 Microcebus murinus 95.26 0.00e+00 1205.00
IUUC-Mdo-062476 Monodelphis domestica 75.85 0.00e+00 951.00
IUUC-Mmu-064212 Mus musculus 87.98 0.00e+00 1127.00
IUUC-Mpu-066496 Mustela putorius furo 92.86 0.00e+00 1201.00
IUUC-Mlu-067539 Myotis lucifugus 91.96 0.00e+00 1188.00
IUUC-Nle-069615 Nomascus leucogenys 99.55 0.00e+00 1313.00
IUUC-Ont-072534 Oreochromis niloticus 48.69 4.00e-83 302.00
IUUC-Oan-073502 Ornithorhynchus anatinus 66.89 3.00e-96 345.00
IUUC-Ocu-074395 Oryctolagus cuniculus 90.92 0.00e+00 1184.00
IUUC-Ola-087440 Oryzias latipes 71.03 3.00e-54 206.00
IUUC-Oga-088841 Otolemur garnettii 94.50 0.00e+00 1216.00
IUUC-Oar-089694 Ovis aries 92.71 0.00e+00 1210.00
IUUC-Ptr-091355 Pan troglodytes 99.85 0.00e+00 1316.00
IUUC-Pan-091850 Papio anubis 98.21 0.00e+00 1305.00
IUUC-Psi-094073 Pelodiscus sinensis 65.79 0.00e+00 826.00
IUUC-Pno-095029 Phaeosphaeria nodorum 35.29 3.00e-05 42.40
IUUC-Pfo-097523 Poecilia formosa 48.11 8.00e-73 268.00
IUUC-Pab-097644 Pongo abelii 99.40 0.00e+00 1311.00
IUUC-Pca-100162 Procavia capensis 90.43 0.00e+00 1181.00
IUUC-Pva-103193 Pteropus vampyrus 94.79 0.00e+00 1225.00
IUUC-Rno-104989 Rattus norvegicus 85.61 0.00e+00 1137.00
IUUC-Sha-107147 Sarcophilus harrisii 76.44 0.00e+00 942.00
IUUC-Sar-113674 Sorex araneus 83.51 0.00e+00 1014.00
IUUC-Ssc-116157 Sus scrofa 93.60 0.00e+00 1187.00
IUUC-Tgu-117210 Taeniopygia guttata 60.88 0.00e+00 753.00
IUUC-Tru-117894 Takifugu rubripes 46.13 3.00e-79 290.00
IUUC-Tni-120188 Tetraodon nigroviridis 48.22 8.00e-79 288.00
IUUC-Tbe-127795 Tupaia belangeri 87.56 0.00e+00 1132.00
IUUC-Ttr-128538 Tursiops truncatus 94.05 0.00e+00 1223.00
IUUC-Vpa-130051 Vicugna pacos 93.33 0.00e+00 793.00
IUUC-Xtr-132437 Xenopus tropicalis 61.21 7.00e-62 232.00
IUUC-Xma-133444 Xiphophorus maculatus 44.98 9.00e-75 274.00
Created Date 25-Jun-2017

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