iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019597.3	ENSMMUT00000027520.3	ENSMMUP00000025739.3
ENSMMUG00000019597.3	ENSMMUT00000054291.1	ENSMMUP00000044387.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-53	177.2	370	408
UBD/Beta-Prp	3.10e-65	221.4	332	536

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++++++
   Q: 370  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDNCVH 408
           8***********778*********************987 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls 99
           ++  +v++ ++++ +a+ s+d +i v ++ +   +++++gh++ev+a+k++p+g++l+++s+D+t+k+w++++  cvh l++h++++++
   Q: 332  APALDVDW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYT 419
           44444555.66666777777777777777777777777777777777777777777777777777777777777777777777777777 PP
   S: 100  lsfsp........sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltggh 179
           +++sp        +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ +tg l++  +g  
   Q: 420  IKWSPtgpgtnnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-- 505
           7777655554443222456777777777777777777777.7777777777777777777777777777777777777777777766.. PP
   S: 180  tdsvyslsfdsngkelvsgsldgtvklwdlq 210
           t+ +  + ++  g  + + + dg+v + dl+
   Q: 506  TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 536
           7777777777777777777777777666654 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

GFIVRQCRTF VLHHLIKSNV GIKMSISSDE VNFLVYRYLQ ESGFSHSAFT FGIESHISQS 60
NINGALVPPA ALISIIQKGL QYVEAEVSIN EDGTLFDGRP IESLSLIDAV MPDVVQTRQQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCAACAAC AGCAACTTGT GATTGGCGGT GACCGGATAT TCAGTTGCAC ATCCCCACAT 60
CAATGCACTG CCAATGGTAA GACTCTCCAG CTCCCAATGT CAGAGTGTTT ATTATTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0060613--P:fat pad development
GO:0016575--P:histone deacetylation
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0050872--P:white fat cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	60.71	6.00e-55	206.00
IUUC-Aml-001717	Ailuropoda melanoleuca	98.83	0.00e+00	956.00
IUUC-Atr-002514	Amborella trichopoda	65.38	8.00e-145	507.00
IUUC-Apl-003708	Anas platyrhynchos	95.75	0.00e+00	911.00
IUUC-Aca-004611	Anolis carolinensis	95.91	0.00e+00	952.00
IUUC-Aly-005622	Arabidopsis lyrata	58.40	2.00e-119	423.00
IUUC-Ath-007137	Arabidopsis thaliana	59.50	4.00e-121	428.00
IUUC-Ame-011601	Astyanax mexicanus	92.22	0.00e+00	903.00
IUUC-Bta-012418	Bos taurus	99.22	0.00e+00	981.00
IUUC-Bdi-014315	Brachypodium distachyon	60.42	1.00e-134	473.00
IUUC-Bol-016277	Brassica oleracea	57.25	5.00e-127	447.00
IUUC-Bra-016944	Brassica rapa	60.56	2.00e-126	446.00
IUUC-Cja-018832	Callithrix jacchus	99.81	0.00e+00	959.00
IUUC-Cfa-020029	Canis familiaris	99.03	0.00e+00	957.00
IUUC-Cpo-022080	Cavia porcellus	93.22	0.00e+00	913.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	60.38	1.00e-130	459.00
IUUC-Csa-024075	Chlorocebus sabaeus	100.00	0.00e+00	957.00
IUUC-Cho-024872	Choloepus hoffmanni	99.15	6.00e-111	394.00
IUUC-Cin-025704	Ciona intestinalis	71.38	0.00e+00	789.00
IUUC-Csv-026257	Ciona savignyi	69.94	0.00e+00	764.00
IUUC-Cme-027258	Cyanidioschyzon merolae	40.35	7.00e-106	377.00
IUUC-Dre-028075	Danio rerio	93.19	0.00e+00	924.00
IUUC-Dno-029196	Dasypus novemcinctus	99.61	0.00e+00	960.00
IUUC-Dor-030732	Dipodomys ordii	99.45	0.00e+00	732.00
IUUC-Dme-031939	Drosophila melanogaster	81.42	2.00e-173	602.00
IUUC-Eeu-034952	Erinaceus europaeus	89.61	0.00e+00	825.00
IUUC-Fca-035734	Felis catus	99.22	0.00e+00	958.00
IUUC-Fal-037185	Ficedula albicollis	96.11	0.00e+00	952.00
IUUC-Gmo-038870	Gadus morhua	90.47	0.00e+00	927.00
IUUC-Gga-041161	Gallus gallus	96.11	0.00e+00	953.00
IUUC-Gac-041844	Gasterosteus aculeatus	92.23	0.00e+00	954.00
IUUC-Gma-044208	Glycine max	48.34	5.00e-153	534.00
IUUC-Ggo-044882	Gorilla gorilla	100.00	0.00e+00	957.00
IUUC-Hsa-046488	Homo sapiens	100.00	0.00e+00	957.00
IUUC-Itr-047958	Ictidomys tridecemlineatus	100.00	0.00e+00	740.00
IUUC-Kpa-049338	Komagataella pastoris	28.91	8.00e-32	131.00
IUUC-Lch-050672	Latimeria chalumnae	96.70	0.00e+00	972.00
IUUC-Lpe-051084	Leersia perrieri	62.64	3.00e-136	478.00
IUUC-Loc-052030	Lepisosteus oculatus	95.95	0.00e+00	959.00
IUUC-Laf-054280	Loxodonta africana	98.83	0.00e+00	979.00
IUUC-Meu-056563	Macropus eugenii	98.32	1.00e-134	473.00
IUUC-Mga-059660	Meleagris gallopavo	96.11	0.00e+00	953.00
IUUC-Mvi-060557	Microbotryum violaceum	36.77	3.00e-70	259.00
IUUC-Mmr-060925	Microcebus murinus	97.80	0.00e+00	917.00
IUUC-Mdo-062078	Monodelphis domestica	98.25	0.00e+00	949.00
IUUC-Mmu-063603	Mus musculus	99.03	0.00e+00	954.00
IUUC-Mpu-066741	Mustela putorius furo	99.03	0.00e+00	957.00
IUUC-Mlu-068152	Myotis lucifugus	99.42	0.00e+00	952.00
IUUC-Nle-069229	Nomascus leucogenys	100.00	0.00e+00	957.00
IUUC-Opr-070277	Ochotona princeps	88.56	0.00e+00	811.00
IUUC-Ont-072623	Oreochromis niloticus	92.43	0.00e+00	954.00
IUUC-Ocu-074280	Oryctolagus cuniculus	97.52	0.00e+00	951.00
IUUC-Obr-076718	Oryza brachyantha	62.91	6.00e-137	481.00
IUUC-Olo-080427	Oryza longistaminata	63.32	6.00e-132	464.00
IUUC-Ola-087365	Oryzias latipes	95.54	0.00e+00	954.00
IUUC-Oga-088357	Otolemur garnettii	92.02	0.00e+00	901.00
IUUC-Oar-089214	Ovis aries	99.42	0.00e+00	985.00
IUUC-Ptr-091532	Pan troglodytes	100.00	0.00e+00	957.00
IUUC-Pan-091927	Papio anubis	100.00	0.00e+00	957.00
IUUC-Psi-093941	Pelodiscus sinensis	92.60	0.00e+00	940.00
IUUC-Ppa-095868	Physcomitrella patens	65.16	1.00e-139	489.00
IUUC-Pfo-096158	Poecilia formosa	92.43	0.00e+00	954.00
IUUC-Pab-098705	Pongo abelii	100.00	0.00e+00	957.00
IUUC-Pop-098989	Populus trichocarpa	61.54	8.00e-128	450.00
IUUC-Pca-100256	Procavia capensis	99.02	0.00e+00	944.00
IUUC-Pva-102616	Pteropus vampyrus	99.01	0.00e+00	936.00
IUUC-Rno-105411	Rattus norvegicus	99.22	0.00e+00	956.00
IUUC-Sce-106132	Saccharomyces cerevisiae	24.78	3.00e-42	166.00
IUUC-Sha-106636	Sarcophilus harrisii	98.06	0.00e+00	951.00
IUUC-Smo-109301	Selaginella moellendorffii	63.49	1.00e-142	499.00
IUUC-Sit-110710	Setaria italica	63.71	2.00e-142	499.00
IUUC-Sly-111042	Solanum lycopersicum	50.68	4.00e-150	524.00
IUUC-Stu-112744	Solanum tuberosum	49.22	1.00e-141	496.00
IUUC-Sar-112971	Sorex araneus	90.20	0.00e+00	866.00
IUUC-Sbi-114420	Sorghum bicolor	63.19	3.00e-142	498.00
IUUC-Sre-115175	Sporisorium reilianum	37.92	1.00e-57	218.00
IUUC-Ssc-115695	Sus scrofa	97.67	0.00e+00	936.00
IUUC-Tgu-117009	Taeniopygia guttata	96.06	0.00e+00	938.00
IUUC-Tru-118581	Takifugu rubripes	95.34	0.00e+00	955.00
IUUC-Tsy-119424	Tarsius syrichta	82.05	0.00e+00	724.00
IUUC-Tni-119986	Tetraodon nigroviridis	95.53	0.00e+00	955.00
IUUC-Tca-121739	Theobroma cacao	54.08	5.00e-125	441.00
IUUC-Tme-127126	Tuber melanosporum	38.42	3.00e-58	219.00
IUUC-Tbe-127665	Tupaia belangeri	82.46	0.00e+00	819.00
IUUC-Vpa-130768	Vicugna pacos	99.61	0.00e+00	944.00
IUUC-Vvi-131193	Vitis vinifera	60.16	2.00e-128	452.00
IUUC-Xtr-132842	Xenopus tropicalis	89.96	0.00e+00	902.00
IUUC-Xma-134020	Xiphophorus maculatus	92.44	0.00e+00	956.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence