iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000178809.11	ENST00000430211.5	ENSP00000410121.1
ENSG00000178809.11	ENST00000447409.6	ENSP00000407135.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Information
OMIM
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18398435

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	0.00013	23.6	12	77
E3 activity/RING/RING	1.60e-06	30.2	16	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIek...wlasggktcPvtrqplteedlvPnltlrrliqa 67
           + + CpI le++++  +l++G++y + ++     +l+++ + cP++ q ++ ++  Pn +l  +i+a
   Q: 12   DRLQCPICLEVFKESLMLQCGHSYCKGCLVSlsyHLDTKVR-CPMCWQVVDGSSSLPNVSLAWVIEA 77
           6689**********************987652227777777.*****************99887765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iCle fk+  l l+CgH +++ Cl   + l++   ++ rCP C
   Q: 16   CPICLEVFKE-SLMLQCGHSYCKGCL---VSLSYHLDTKVRCPMC 56
           ********99.899************...5668889********* PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAWQVSLLEL EDRLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK VRCPMCWQVV 60
DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATGACGTC CTTCAGCACG CCCCGGTCCC CCGAGATGTC CAGCATCCTC TGACTTAACC 60
GCTCGTACAG GGACTGATGG AGAATGAAAG CCAGGCCTCA GAGCCGCAGA CCCACCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0008270--F:zinc ion binding

KEGG

hsa:375593

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ggo-044729	Gorilla gorilla	95.60	5.00e-138	483.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence