iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
miRecords	RepTar	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	9.60e-16	59.0	34	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv++ v+g+ef++h++vLaa+S++F++lf+++    + ++ +ei+ v++e++ al++F Yt +l+ 
   Q: 34   CDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQ-QNVYEIDFVSAEALTALMDFAYTATLTV 99
           8**********************************666.9**********************99975 PP

Organism

Mus musculus

Functional Description
(View)

Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.

Protein Sequence
(Fasta)

MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS VLAACSQYFK 60
KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS TANVGDILSA ARLLEIPAVS 120

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Nucleotide Sequence
(Fasta)

GGGGGTGAAA AAAAAAGAAA GAAAGAAAGA AAGAAAACAG AAAACGCAGG GTTGGATTCG 60
CACTTTCCTA CTTCCCACCT CTGTCCTGCG GAGCTGTGCG GCGCCCCTGC GAGGGTCCGG 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0035035--F:histone acetyltransferase binding
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0051216--P:cartilage development
GO:0030154--P:cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:16969

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001947	Ailuropoda melanoleuca	92.68	1.00e-83	301.00
IUUC-Apl-003455	Anas platyrhynchos	65.24	0.00e+00	651.00
IUUC-Ame-011315	Astyanax mexicanus	65.60	1.00e-79	290.00
IUUC-Bta-012885	Bos taurus	84.95	0.00e+00	770.00
IUUC-Cja-019289	Callithrix jacchus	82.88	0.00e+00	778.00
IUUC-Cfa-020143	Canis familiaris	87.04	0.00e+00	747.00
IUUC-Cpo-021474	Cavia porcellus	80.07	0.00e+00	764.00
IUUC-Csa-024242	Chlorocebus sabaeus	81.26	0.00e+00	731.00
IUUC-Cin-025467	Ciona intestinalis	44.64	1.00e-25	108.00
IUUC-Dre-027425	Danio rerio	49.81	4.00e-124	438.00
IUUC-Dno-029452	Dasypus novemcinctus	81.04	6.00e-176	610.00
IUUC-Dor-031002	Dipodomys ordii	89.04	0.00e+00	652.00
IUUC-Eeu-034736	Erinaceus europaeus	89.47	2.00e-83	303.00
IUUC-Fal-037513	Ficedula albicollis	68.16	0.00e+00	677.00
IUUC-Gga-040265	Gallus gallus	69.84	0.00e+00	637.00
IUUC-Gac-041962	Gasterosteus aculeatus	70.56	5.00e-85	308.00
IUUC-Ggo-045371	Gorilla gorilla	66.07	2.00e-171	595.00
IUUC-Hsa-046303	Homo sapiens	85.05	0.00e+00	803.00
IUUC-Itr-047921	Ictidomys tridecemlineatus	87.95	3.00e-87	315.00
IUUC-Lch-049776	Latimeria chalumnae	55.96	2.00e-153	536.00
IUUC-Loc-052112	Lepisosteus oculatus	67.87	3.00e-82	299.00
IUUC-Meu-056706	Macropus eugenii	74.55	0.00e+00	697.00
IUUC-Mga-060164	Meleagris gallopavo	69.23	0.00e+00	632.00
IUUC-Mmr-061124	Microcebus murinus	82.65	0.00e+00	700.00
IUUC-Mdo-061864	Monodelphis domestica	88.10	6.00e-104	370.00
IUUC-Mpu-065739	Mustela putorius furo	86.25	0.00e+00	779.00
IUUC-Mlu-067158	Myotis lucifugus	82.03	0.00e+00	733.00
IUUC-Opr-070700	Ochotona princeps	74.35	0.00e+00	660.00
IUUC-Ont-071557	Oreochromis niloticus	60.00	4.00e-79	289.00
IUUC-Oan-073589	Ornithorhynchus anatinus	76.72	5.00e-101	361.00
IUUC-Oga-089163	Otolemur garnettii	84.29	0.00e+00	806.00
IUUC-Oar-089886	Ovis aries	84.91	0.00e+00	728.00
IUUC-Ptr-091558	Pan troglodytes	85.05	0.00e+00	803.00
IUUC-Pan-092337	Papio anubis	81.26	0.00e+00	731.00
IUUC-Psi-093220	Pelodiscus sinensis	70.76	0.00e+00	653.00
IUUC-Pma-094176	Petromyzon marinus	41.72	7.00e-28	118.00
IUUC-Pfo-096769	Poecilia formosa	63.60	3.00e-78	286.00
IUUC-Pab-097551	Pongo abelii	86.59	2.00e-175	608.00
IUUC-Pva-102777	Pteropus vampyrus	77.74	0.00e+00	662.00
IUUC-Rno-106040	Rattus norvegicus	97.19	0.00e+00	882.00
IUUC-Sha-107596	Sarcophilus harrisii	71.75	0.00e+00	659.00
IUUC-Ssc-116026	Sus scrofa	83.83	0.00e+00	810.00
IUUC-Tru-118073	Takifugu rubripes	65.52	7.00e-71	261.00
IUUC-Tni-120736	Tetraodon nigroviridis	71.90	8.00e-83	300.00
IUUC-Ttr-128563	Tursiops truncatus	82.01	0.00e+00	731.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence