iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000179262.9	ENST00000591499.5	ENSP00000466243.1
ENSG00000179262.9	ENST00000316856.7	ENSP00000321365.3
ENSG00000179262.9	ENST00000586534.5	ENSP00000467024.1
ENSG00000179262.9	ENST00000592268.5	ENSP00000468674.1
ENSG00000179262.9	ENST00000586375.1	ENSP00000466226.1
ENSG00000179262.9	ENST00000590881.1	ENSP00000467628.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15321727; 15949443; 16405905; 17098253; 17242378
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	10708769; 10915768; 11827521; 12970176; 14557549

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	2.10e-20	73.8	162	201
ULD/UDP/UBQ/UBQ_PIM	1.10e-25	91.0	3	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+e +l ++++MG++re+++ aLra++nn+ +AveyLl+g
   Q: 162  EYETMLTEIMSMGYERERVVAALRASYNNPHRAVEYLLTG 201
           7899**********************************97 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           +++t+ktl++++f++++++d+tv+ lKeki++e+g   +p++ qkLIyaGkiL+Dd +++++ i+++++v+++v+k+k
   Q: 3    VTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGrdaFPVAGQKLIYAGKILSDDVPIRDYRIDEKNFVVVMVTKTK 80
           68*************************************************************************987 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3. Interacts with HIV-1 vpr. Interacts with UBQLN2.

Protein Sequence
(Fasta)

MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP 60
IRDYRIDEKN FVVVMVTKTK AGQGTSAPPE ASPTAAPESS TSFPPAPTSG MSHPPPAARE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGGCGCG GCGCGCCTGG GCGCTAAGAT GGCGGCGGCG TGAGTTGCAT GTTGTGTGAG 60
GATCCCGGGG CCGCCGCGTC GCTCGGGCCC CGCCATGGCC GTCACCATCA CGCTCAAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding

PRINTS

PR01839--RAD23PROTEIN

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0005654--C:nucleoplasm
GO:0000502--C:proteasome complex
GO:0003684--F:damaged DNA binding
GO:0031593--F:polyubiquitin binding
GO:0003697--F:single-stranded DNA binding
GO:1990381--F:ubiquitin-specific protease binding
GO:0006289--P:nucleotide-excision repair
GO:0045070--P:positive regulation of viral genome replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process

KEGG

hsa:5886

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000770	Aegilops tauschii	38.11	2.00e-32	133.00
IUUC-Aml-001515	Ailuropoda melanoleuca	93.04	1.00e-144	506.00
IUUC-Atr-002756	Amborella trichopoda	35.31	1.00e-49	190.00
IUUC-Aca-004704	Anolis carolinensis	78.77	9.00e-113	400.00
IUUC-Ani-009460	Aspergillus nidulans	38.80	3.00e-29	122.00
IUUC-Bgr-012056	Blumeria graminis	33.66	2.00e-21	96.70
IUUC-Bta-012377	Bos taurus	96.14	1.00e-148	518.00
IUUC-Bci-013933	Botrytis cinerea	37.31	9.00e-21	94.40
IUUC-Bdi-014718	Brachypodium distachyon	30.60	1.00e-40	160.00
IUUC-Cel-018364	Caenorhabditis elegans	31.98	1.00e-28	120.00
IUUC-Cja-018946	Callithrix jacchus	98.62	2.00e-149	521.00
IUUC-Cfa-020577	Canis familiaris	97.25	4.00e-155	540.00
IUUC-Cpo-021850	Cavia porcellus	93.11	6.00e-167	580.00
IUUC-Csa-023183	Chlorocebus sabaeus	99.72	9.00e-157	546.00
IUUC-Cgl-026495	Colletotrichum gloeosporioides	33.00	1.00e-21	97.10
IUUC-Dno-030017	Dasypus novemcinctus	92.37	1.00e-129	456.00
IUUC-Dor-030358	Dipodomys ordii	84.62	2.00e-126	445.00
IUUC-Eca-033599	Equus caballus	93.51	2.00e-138	484.00
IUUC-Fca-036051	Felis catus	96.42	7.00e-153	533.00
IUUC-Gmo-038528	Gadus morhua	57.46	2.00e-85	308.00
IUUC-Gga-040133	Gallus gallus	86.98	6.00e-75	274.00
IUUC-Gma-044077	Glycine max	34.95	8.00e-46	177.00
IUUC-Ggo-045084	Gorilla gorilla	100.00	1.00e-156	546.00
IUUC-Itr-047875	Ictidomys tridecemlineatus	97.52	2.00e-175	608.00
IUUC-Lch-050563	Latimeria chalumnae	62.56	1.00e-104	372.00
IUUC-Laf-054589	Loxodonta africana	96.97	6.00e-147	513.00
IUUC-Mcc-055860	Macaca mulatta	99.72	9.00e-157	546.00
IUUC-Meu-056459	Macropus eugenii	93.95	7.00e-105	374.00
IUUC-Mmr-060819	Microcebus murinus	97.25	1.00e-167	582.00
IUUC-Mdo-062742	Monodelphis domestica	85.55	1.00e-144	505.00
IUUC-Mmu-063929	Mus musculus	94.77	4.00e-164	570.00
IUUC-Mac-065180	Musa acuminata	34.53	1.00e-43	171.00
IUUC-Mpu-066684	Mustela putorius furo	97.25	1.00e-157	548.00
IUUC-Mlu-067787	Myotis lucifugus	95.04	6.00e-152	530.00
IUUC-Nle-069846	Nomascus leucogenys	88.28	3.00e-136	478.00
IUUC-Ont-072271	Oreochromis niloticus	56.46	6.00e-89	320.00
IUUC-Oan-073572	Ornithorhynchus anatinus	80.17	2.00e-131	462.00
IUUC-Ocu-074968	Oryctolagus cuniculus	96.02	8.00e-106	378.00
IUUC-Oba-075392	Oryza barthii	38.71	4.00e-32	132.00
IUUC-Obr-076660	Oryza brachyantha	34.78	3.00e-45	176.00
IUUC-Ogu-078883	Oryza glumaepatula	38.71	4.00e-32	132.00
IUUC-Oin-079817	Oryza indica	38.71	4.00e-32	132.00
IUUC-Olo-080929	Oryza longistaminata	38.71	3.00e-32	132.00
IUUC-Ome-081866	Oryza meridionalis	38.71	3.00e-32	132.00
IUUC-Oni-083092	Oryza nivara	38.71	4.00e-32	132.00
IUUC-Opu-083756	Oryza punctata	39.44	7.00e-34	138.00
IUUC-Oru-084816	Oryza rufipogon	38.71	4.00e-32	132.00
IUUC-Osa-086112	Oryza sativa	38.71	4.00e-32	132.00
IUUC-Oga-089075	Otolemur garnettii	96.97	8.00e-150	523.00
IUUC-Oar-090387	Ovis aries	95.87	9.00e-146	509.00
IUUC-Ptr-090912	Pan troglodytes	96.42	9.00e-147	513.00
IUUC-Pan-092140	Papio anubis	99.72	5.00e-156	543.00
IUUC-Psi-093347	Pelodiscus sinensis	66.87	1.00e-67	249.00
IUUC-Pno-095064	Phaeosphaeria nodorum	36.82	7.00e-18	85.10
IUUC-Ppa-095654	Physcomitrella patens	40.00	3.00e-35	142.00
IUUC-Pfo-096607	Poecilia formosa	64.29	2.00e-95	342.00
IUUC-Pab-097738	Pongo abelii	96.14	6.00e-151	526.00
IUUC-Pca-100348	Procavia capensis	93.96	4.00e-145	507.00
IUUC-Ppe-101522	Prunus persica	33.50	6.00e-50	191.00
IUUC-Pva-102412	Pteropus vampyrus	96.97	3.00e-156	544.00
IUUC-Pgr-103618	Puccinia graminis	37.31	6.00e-25	108.00
IUUC-Rno-105569	Rattus norvegicus	95.04	2.00e-150	525.00
IUUC-Sha-106918	Sarcophilus harrisii	86.30	8.00e-131	460.00
IUUC-Sja-107851	Schizosaccharomyces japonicus	35.29	2.00e-43	169.00
IUUC-Smo-109129	Selaginella moellendorffii	38.65	4.00e-32	132.00
IUUC-Sit-109813	Setaria italica	35.94	1.00e-46	180.00
IUUC-Sbi-114459	Sorghum bicolor	32.03	8.00e-45	174.00
IUUC-Ssc-115460	Sus scrofa	96.69	2.00e-154	538.00
IUUC-Tsy-119385	Tarsius syrichta	81.62	3.00e-72	264.00
IUUC-Tni-120493	Tetraodon nigroviridis	60.17	3.00e-94	338.00
IUUC-Tre-121911	Trichoderma reesei	33.58	8.00e-28	117.00
IUUC-Tur-126610	Triticum urartu	38.11	1.00e-32	135.00
IUUC-Tbe-127603	Tupaia belangeri	84.67	4.00e-55	208.00
IUUC-Ttr-129232	Tursiops truncatus	86.78	1.00e-144	506.00
IUUC-Vda-129946	Verticillium dahliae	33.33	7.00e-21	94.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence