iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	8.30e-18	66.2	49	112
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.00e-12	46.1	148	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +D+il vg+++++ahk+vLa+ S++F+a+f+++l+e++ +++ve++ ++ ++++a++++ Ytg++
   Q: 49   CDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKE-NSEVEFQCIDETALQAIVEYAYTGTV 112
           8***********************************97.************************87 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + Nc+gi rfA++y+c+dL++aa ++i+++F+
   Q: 148  PGNCIGISRFAETYGCRDLYLAATKYICQNFE 179
           56*****************************5 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MHFKCKYSYP ALYQMDHTSP TYMLANLTHL HSEQLLQGLN LLRQHHELCD IILRVGDVKI 60
HAHKVVLASV SPYFKAMFTG NLSEKENSEV EFQCIDETAL QAIVEYAYTG TVFISQDTVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAATTTTTT CCCTAGTGTT CCAGAGAGCT ACCAAAGTGC TTTCTGTGAG GAAGTCCCAT 60
GGTCTGGTTT ATATCTTAAC AGCATCAATG GCTGTTATAT GAGATGGAGT AATAATGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030569--KLHL28
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001581	Ailuropoda melanoleuca	98.95	0.00e+00	1190.00
IUUC-Apl-003577	Anas platyrhynchos	92.61	0.00e+00	1088.00
IUUC-Aca-004320	Anolis carolinensis	86.56	0.00e+00	924.00
IUUC-Ame-011433	Astyanax mexicanus	84.41	0.00e+00	986.00
IUUC-Bta-012650	Bos taurus	99.12	0.00e+00	1190.00
IUUC-Cja-019878	Callithrix jacchus	99.13	0.00e+00	1192.00
IUUC-Cfa-020936	Canis familiaris	99.12	0.00e+00	1190.00
IUUC-Cpo-022212	Cavia porcellus	97.55	0.00e+00	1176.00
IUUC-Csa-023372	Chlorocebus sabaeus	99.47	0.00e+00	1192.00
IUUC-Cho-024885	Choloepus hoffmanni	97.99	2.00e-173	602.00
IUUC-Dno-029895	Dasypus novemcinctus	97.55	0.00e+00	1174.00
IUUC-Ete-032703	Echinops telfairi	97.99	0.00e+00	917.00
IUUC-Eca-034150	Equus caballus	98.95	0.00e+00	1188.00
IUUC-Eeu-035233	Erinaceus europaeus	96.50	0.00e+00	1164.00
IUUC-Fca-036445	Felis catus	98.77	0.00e+00	1185.00
IUUC-Fal-037156	Ficedula albicollis	82.14	0.00e+00	997.00
IUUC-Gmo-039158	Gadus morhua	84.41	0.00e+00	1016.00
IUUC-Gga-040855	Gallus gallus	91.42	0.00e+00	1121.00
IUUC-Gac-041294	Gasterosteus aculeatus	83.71	0.00e+00	1007.00
IUUC-Ggo-045399	Gorilla gorilla	100.00	0.00e+00	1228.00
IUUC-Itr-048859	Ictidomys tridecemlineatus	98.77	0.00e+00	1182.00
IUUC-Lch-049445	Latimeria chalumnae	88.14	0.00e+00	814.00
IUUC-Loc-052737	Lepisosteus oculatus	85.99	0.00e+00	1012.00
IUUC-Laf-054173	Loxodonta africana	98.25	0.00e+00	1177.00
IUUC-Mcc-055000	Macaca mulatta	99.32	0.00e+00	1221.00
IUUC-Meu-056028	Macropus eugenii	86.05	8.00e-145	507.00
IUUC-Mga-059609	Meleagris gallopavo	92.35	0.00e+00	1119.00
IUUC-Mmr-060842	Microcebus murinus	98.46	0.00e+00	1203.00
IUUC-Mdo-062776	Monodelphis domestica	92.66	0.00e+00	1088.00
IUUC-Mmu-063720	Mus musculus	97.02	0.00e+00	1172.00
IUUC-Mpu-066594	Mustela putorius furo	68.28	0.00e+00	731.00
IUUC-Mlu-067403	Myotis lucifugus	97.02	0.00e+00	1165.00
IUUC-Nle-069242	Nomascus leucogenys	99.30	0.00e+00	1190.00
IUUC-Opr-070942	Ochotona princeps	96.79	9.00e-180	622.00
IUUC-Ont-072586	Oreochromis niloticus	84.62	0.00e+00	1017.00
IUUC-Oan-073070	Ornithorhynchus anatinus	93.24	0.00e+00	1081.00
IUUC-Ocu-074536	Oryctolagus cuniculus	97.60	0.00e+00	1199.00
IUUC-Ola-086669	Oryzias latipes	70.98	0.00e+00	818.00
IUUC-Oga-088974	Otolemur garnettii	98.95	0.00e+00	1187.00
IUUC-Oar-089544	Ovis aries	98.78	0.00e+00	1191.00
IUUC-Ptr-091478	Pan troglodytes	99.66	0.00e+00	1219.00
IUUC-Pan-092653	Papio anubis	99.65	0.00e+00	1192.00
IUUC-Psi-094014	Pelodiscus sinensis	93.35	0.00e+00	1130.00
IUUC-Pfo-097316	Poecilia formosa	83.13	0.00e+00	1013.00
IUUC-Pab-098609	Pongo abelii	99.83	0.00e+00	1226.00
IUUC-Pva-102527	Pteropus vampyrus	96.81	4.00e-180	624.00
IUUC-Rno-105188	Rattus norvegicus	97.55	0.00e+00	1175.00
IUUC-Sha-106543	Sarcophilus harrisii	93.18	0.00e+00	1095.00
IUUC-Sar-113507	Sorex araneus	96.15	0.00e+00	1162.00
IUUC-Ssc-115803	Sus scrofa	98.77	0.00e+00	1185.00
IUUC-Tgu-116661	Taeniopygia guttata	81.75	0.00e+00	912.00
IUUC-Tru-118738	Takifugu rubripes	81.46	0.00e+00	984.00
IUUC-Tsy-119570	Tarsius syrichta	90.26	0.00e+00	1090.00
IUUC-Tni-120041	Tetraodon nigroviridis	83.04	0.00e+00	1004.00
IUUC-Tbe-127655	Tupaia belangeri	91.78	0.00e+00	1064.00
IUUC-Ttr-129249	Tursiops truncatus	98.46	0.00e+00	1211.00
IUUC-Vpa-130034	Vicugna pacos	97.09	0.00e+00	1188.00
IUUC-Xtr-132964	Xenopus tropicalis	87.39	0.00e+00	1060.00
IUUC-Xma-133894	Xiphophorus maculatus	84.06	0.00e+00	1007.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence