iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/RAWUL	RAWUL	18588675; 21282530; 22325352

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0035	19.5	18	56
ULD/UDP/UFD/RAWUL	7.00e-32	111.4	139	250

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C iC+  + +++ v+ C H+f+++C+ q++      +  ++ CP C
   Q: 18   CYICKGYLIKPTTVTECLHTFCKTCIvQHF------EDSND-CPRC 56
           99********999*************7777......55555.9988 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk...lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk............. 76
           i+++L++l++n++++d++   l+kk++rcs+r+tV+++kkfl++klkl+ssye+d+lc++e++++++t+e+i y+++w+             
   Q: 139  IAICLDCLRNNGQSGDNVvkgLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFI-YMTRWRlrgenfrclncsa 229
           79**********************************************************************.******************* PP
   S: 77   ...........kegpLvLqYr 86
                      +++p+vLqYr
   Q: 230  sqvcsqdgplyQSYPMVLQYR 250
           ********************9 PP

Organism

Homo sapiens

Functional Description
(View)

Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.

Protein Sequence
(Fasta)

MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS NDCPRCGNQV 60
HETNPLEMLR LDNTLEEIIF KLVPGLREQE LERESEFWKK NKPQENGQDD TSKADKPKVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCACGCGCG CGCGCTCGCG CACCACGCGC CCCGCGCGGC CCGCCCGGAT CGTGGCCTCT 60
CGAGAGCAAG GTAAGGGCGA TGCGCGGGGA CCCAGGCGGC TTCCCCGCCC GACGCGGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005813--C:centrosome
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0008270--F:zinc ion binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:84333

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002093	Ailuropoda melanoleuca	98.07	6.00e-134	469.00
IUUC-Apl-003757	Anas platyrhynchos	95.31	1.00e-122	432.00
IUUC-Aca-005032	Anolis carolinensis	88.28	3.00e-112	397.00
IUUC-Ame-011418	Astyanax mexicanus	69.11	1.00e-93	335.00
IUUC-Bta-013081	Bos taurus	98.44	6.00e-133	466.00
IUUC-Cja-019296	Callithrix jacchus	95.31	3.00e-133	467.00
IUUC-Cfa-020437	Canis familiaris	98.44	5.00e-134	469.00
IUUC-Cpo-022107	Cavia porcellus	98.06	9.00e-134	469.00
IUUC-Csa-023103	Chlorocebus sabaeus	100.00	6.00e-136	476.00
IUUC-Cho-025053	Choloepus hoffmanni	54.69	1.00e-58	219.00
IUUC-Dre-028409	Danio rerio	71.88	2.00e-97	348.00
IUUC-Dno-030077	Dasypus novemcinctus	98.44	3.00e-134	470.00
IUUC-Dor-030893	Dipodomys ordii	98.62	3.00e-111	394.00
IUUC-Ete-033131	Echinops telfairi	80.47	2.00e-107	381.00
IUUC-Eca-034226	Equus caballus	95.70	8.00e-130	456.00
IUUC-Eeu-034466	Erinaceus europaeus	80.47	2.00e-104	371.00
IUUC-Fca-035545	Felis catus	99.22	2.00e-135	474.00
IUUC-Fal-037615	Ficedula albicollis	95.31	1.00e-122	432.00
IUUC-Gmo-038871	Gadus morhua	68.24	3.00e-80	291.00
IUUC-Gga-040926	Gallus gallus	93.75	6.00e-128	449.00
IUUC-Gac-042006	Gasterosteus aculeatus	76.08	2.00e-99	355.00
IUUC-Ggo-045087	Gorilla gorilla	100.00	6.00e-136	476.00
IUUC-Itr-048443	Ictidomys tridecemlineatus	98.41	6.00e-93	332.00
IUUC-Lch-050434	Latimeria chalumnae	82.42	4.00e-114	404.00
IUUC-Loc-052649	Lepisosteus oculatus	78.21	1.00e-105	375.00
IUUC-Laf-053509	Loxodonta africana	98.83	1.00e-134	472.00
IUUC-Mcc-055709	Macaca mulatta	99.61	2.00e-135	474.00
IUUC-Meu-056663	Macropus eugenii	78.12	5.00e-103	367.00
IUUC-Mga-059573	Meleagris gallopavo	93.70	2.00e-126	444.00
IUUC-Mmr-060776	Microcebus murinus	98.44	4.00e-133	467.00
IUUC-Mdo-061959	Monodelphis domestica	97.66	5.00e-133	466.00
IUUC-Mmu-063483	Mus musculus	89.45	3.00e-110	390.00
IUUC-Mpu-066861	Mustela putorius furo	99.22	2.00e-135	474.00
IUUC-Mlu-067880	Myotis lucifugus	98.83	1.00e-134	472.00
IUUC-Nle-069264	Nomascus leucogenys	100.00	6.00e-136	476.00
IUUC-Opr-070746	Ochotona princeps	70.70	3.00e-82	297.00
IUUC-Ont-071361	Oreochromis niloticus	75.19	3.00e-99	354.00
IUUC-Oan-073482	Ornithorhynchus anatinus	80.23	2.00e-105	374.00
IUUC-Ocu-073885	Oryctolagus cuniculus	98.44	3.00e-134	470.00
IUUC-Ola-086999	Oryzias latipes	76.47	9.00e-105	372.00
IUUC-Oga-088504	Otolemur garnettii	98.44	2.00e-134	471.00
IUUC-Oar-089963	Ovis aries	98.44	2.00e-134	471.00
IUUC-Ptr-090820	Pan troglodytes	99.22	3.00e-135	473.00
IUUC-Pan-092600	Papio anubis	99.61	2.00e-135	474.00
IUUC-Psi-093699	Pelodiscus sinensis	94.53	7.00e-122	429.00
IUUC-Pma-094238	Petromyzon marinus	64.59	2.00e-87	315.00
IUUC-Pfo-096402	Poecilia formosa	71.71	1.00e-94	338.00
IUUC-Pab-097621	Pongo abelii	100.00	6.00e-136	476.00
IUUC-Pca-100342	Procavia capensis	97.66	4.00e-134	470.00
IUUC-Pva-103118	Pteropus vampyrus	98.83	3.00e-128	451.00
IUUC-Rno-105427	Rattus norvegicus	95.56	8.00e-105	372.00
IUUC-Sha-107627	Sarcophilus harrisii	92.06	3.00e-90	323.00
IUUC-Sar-113005	Sorex araneus	86.33	3.00e-121	427.00
IUUC-Ssc-116448	Sus scrofa	82.76	7.00e-76	276.00
IUUC-Tgu-117081	Taeniopygia guttata	95.31	1.00e-122	432.00
IUUC-Tru-117696	Takifugu rubripes	70.68	3.00e-95	341.00
IUUC-Tsy-119052	Tarsius syrichta	83.49	5.00e-97	346.00
IUUC-Tni-120530	Tetraodon nigroviridis	72.69	4.00e-92	330.00
IUUC-Tbe-127914	Tupaia belangeri	79.69	2.00e-106	378.00
IUUC-Ttr-128739	Tursiops truncatus	83.98	7.00e-106	376.00
IUUC-Vpa-130189	Vicugna pacos	97.66	1.00e-131	461.00
IUUC-Xtr-131995	Xenopus tropicalis	77.82	1.00e-101	362.00
IUUC-Xma-133038	Xiphophorus maculatus	76.68	2.00e-88	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence