iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/RAWUL	1.30e-32	113.3	139	230

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk...lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk....kegpLv 82
           i+++L++l++n++++d++   l+kk++rcs+r+tV+++kkfl++klkl+ssye+d+lc++e++++++t+e+i y+++w+    +++p+v
   Q: 139  IAICLDCLRNNGQSGDNVvkgLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFI-YMTRWRlrgeNSYPMV 226
           79**********************************************************************.*********9****** PP
   S: 83   LqYr 86
           LqYr
   Q: 227  LQYR 230
           ***9 PP

Organism

Mus musculus

Functional Description
(View)

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).

Protein Sequence
(Fasta)

MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS NDCPRCGNQV 60
HETNPLEMLR LDNTLEEIIF KLVPGLREQE LQRELEFWKK NKPQENGQDD ISKVDKSKAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGGGGCTT CTGGACATGG GGACCAGGAT GCCCCAGACT ATGTCCCATC CCATCGTGCA 60
TCTCACTAGT ACTGTGACCT TGAACAAAAA AACGTGAGTT CAGTTTCTTC TGCAAACTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005813--C:centrosome
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0008270--F:zinc ion binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:76073

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002093	Ailuropoda melanoleuca	89.19	2.00e-123	434.00
IUUC-Apl-003757	Anas platyrhynchos	87.89	3.00e-115	407.00
IUUC-Aca-005032	Anolis carolinensis	82.03	8.00e-106	376.00
IUUC-Ame-011418	Astyanax mexicanus	74.90	2.00e-99	354.00
IUUC-Bta-013081	Bos taurus	89.84	2.00e-123	434.00
IUUC-Cja-019296	Callithrix jacchus	88.67	7.00e-121	426.00
IUUC-Cfa-020437	Canis familiaris	89.45	1.00e-123	435.00
IUUC-Cpo-022107	Cavia porcellus	89.92	3.00e-124	437.00
IUUC-Csa-023103	Chlorocebus sabaeus	89.45	2.00e-116	411.00
IUUC-Cho-025053	Choloepus hoffmanni	54.69	2.00e-58	219.00
IUUC-Dre-028409	Danio rerio	77.97	2.00e-103	368.00
IUUC-Dno-030077	Dasypus novemcinctus	90.23	6.00e-125	439.00
IUUC-Dor-030893	Dipodomys ordii	88.53	5.00e-101	360.00
IUUC-Ete-033131	Echinops telfairi	71.88	1.00e-90	325.00
IUUC-Eca-034226	Equus caballus	86.72	2.00e-119	421.00
IUUC-Eeu-034466	Erinaceus europaeus	73.44	3.00e-93	334.00
IUUC-Fca-035545	Felis catus	90.23	4.00e-125	440.00
IUUC-Fal-037615	Ficedula albicollis	87.89	3.00e-115	407.00
IUUC-Gmo-038871	Gadus morhua	68.65	3.00e-81	294.00
IUUC-Gga-040926	Gallus gallus	87.11	2.00e-114	405.00
IUUC-Gac-042006	Gasterosteus aculeatus	75.00	3.00e-96	344.00
IUUC-Ggo-045087	Gorilla gorilla	89.45	2.00e-116	411.00
IUUC-Hsa-046738	Homo sapiens	89.45	2.00e-116	411.00
IUUC-Itr-048443	Ictidomys tridecemlineatus	87.30	1.00e-82	298.00
IUUC-Lch-050434	Latimeria chalumnae	81.64	7.00e-109	386.00
IUUC-Loc-052649	Lepisosteus oculatus	77.82	3.00e-108	384.00
IUUC-Laf-053509	Loxodonta africana	90.23	5.00e-125	439.00
IUUC-Mcc-055709	Macaca mulatta	89.45	2.00e-116	411.00
IUUC-Meu-056663	Macropus eugenii	72.66	9.00e-93	332.00
IUUC-Mga-059573	Meleagris gallopavo	87.01	4.00e-113	400.00
IUUC-Mmr-060776	Microcebus murinus	89.45	1.00e-122	432.00
IUUC-Mdo-061959	Monodelphis domestica	88.67	7.00e-122	429.00
IUUC-Mpu-066861	Mustela putorius furo	90.23	4.00e-125	440.00
IUUC-Mlu-067880	Myotis lucifugus	90.23	5.00e-125	439.00
IUUC-Nle-069264	Nomascus leucogenys	89.45	2.00e-116	411.00
IUUC-Opr-070746	Ochotona princeps	64.45	7.00e-75	273.00
IUUC-Ont-071361	Oreochromis niloticus	74.13	4.00e-101	360.00
IUUC-Oan-073482	Ornithorhynchus anatinus	81.17	7.00e-95	339.00
IUUC-Ocu-073885	Oryctolagus cuniculus	90.23	6.00e-125	439.00
IUUC-Ola-086999	Oryzias latipes	73.33	2.00e-99	354.00
IUUC-Oga-088504	Otolemur garnettii	89.45	2.00e-124	438.00
IUUC-Oar-089963	Ovis aries	90.23	2.00e-125	441.00
IUUC-Ptr-090820	Pan troglodytes	88.67	1.00e-115	408.00
IUUC-Pan-092600	Papio anubis	89.45	2.00e-116	411.00
IUUC-Psi-093699	Pelodiscus sinensis	87.89	1.00e-122	432.00
IUUC-Pma-094238	Petromyzon marinus	62.60	1.00e-85	309.00
IUUC-Pfo-096402	Poecilia formosa	78.57	3.00e-100	357.00
IUUC-Pab-097621	Pongo abelii	89.45	2.00e-116	411.00
IUUC-Pca-100342	Procavia capensis	89.06	5.00e-116	410.00
IUUC-Pva-103118	Pteropus vampyrus	90.23	5.00e-119	420.00
IUUC-Rno-105427	Rattus norvegicus	98.64	1.00e-113	402.00
IUUC-Sha-107627	Sarcophilus harrisii	84.13	2.00e-78	284.00
IUUC-Sar-113005	Sorex araneus	76.95	2.00e-110	391.00
IUUC-Ssc-116448	Sus scrofa	79.25	2.00e-81	295.00
IUUC-Tgu-117081	Taeniopygia guttata	87.89	3.00e-115	407.00
IUUC-Tru-117696	Takifugu rubripes	68.80	1.00e-92	332.00
IUUC-Tsy-119052	Tarsius syrichta	73.39	2.00e-86	311.00
IUUC-Tni-120530	Tetraodon nigroviridis	73.23	1.00e-92	332.00
IUUC-Tbe-127914	Tupaia belangeri	71.88	6.00e-91	327.00
IUUC-Ttr-128739	Tursiops truncatus	75.39	7.00e-96	343.00
IUUC-Vpa-130189	Vicugna pacos	89.45	3.00e-122	430.00
IUUC-Xtr-131995	Xenopus tropicalis	85.07	2.00e-99	354.00
IUUC-Xma-133038	Xiphophorus maculatus	74.48	9.00e-91	326.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence