iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRecords	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.70e-07	32.1	104	165

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv++ + g+  +ah++vLaa S++F++ +l + ++       ei   v+ ++++ l++F+Y+g l+ 
   Q: 104  CDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDI------EIPSvVSVQSVQKLIDFMYSGVLRV 165
           8*****************************9888875......577557788************9976 PP

Organism

Homo sapiens

Functional Description
(View)

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.

Protein Sequence
(Fasta)

MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH STHSLTNSHA 60
HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGGGGG GAAGTTTAGG AGTTGAGGAA AGAAGATTAA AGAGCGCGAG GAGGTAATGC 60
CACAAACTCT AATTTGTTGT GGGACGGGCG GGAGAGAGGG AGGAGTGTGT GCGTGCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0032728--P:positive regulation of interferon-beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:26137

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002366	Ailuropoda melanoleuca	98.52	0.00e+00	1398.00
IUUC-Apl-003862	Anas platyrhynchos	89.44	0.00e+00	1310.00
IUUC-Aca-005090	Anolis carolinensis	86.04	0.00e+00	1265.00
IUUC-Ame-010940	Astyanax mexicanus	67.57	0.00e+00	726.00
IUUC-Bta-012346	Bos taurus	98.37	0.00e+00	1435.00
IUUC-Cja-019161	Callithrix jacchus	99.46	0.00e+00	1439.00
IUUC-Cfa-020769	Canis familiaris	99.19	0.00e+00	1409.00
IUUC-Cpo-021745	Cavia porcellus	96.90	0.00e+00	1369.00
IUUC-Csa-024179	Chlorocebus sabaeus	99.40	0.00e+00	1290.00
IUUC-Cho-024960	Choloepus hoffmanni	97.45	0.00e+00	924.00
IUUC-Dre-028517	Danio rerio	67.85	0.00e+00	717.00
IUUC-Dno-029085	Dasypus novemcinctus	98.25	0.00e+00	1407.00
IUUC-Dor-030803	Dipodomys ordii	98.25	0.00e+00	1421.00
IUUC-Ete-032886	Echinops telfairi	97.74	1.00e-153	537.00
IUUC-Eca-034022	Equus caballus	98.50	0.00e+00	1254.00
IUUC-Eeu-035184	Erinaceus europaeus	97.75	0.00e+00	1255.00
IUUC-Fca-035822	Felis catus	96.49	0.00e+00	1380.00
IUUC-Fal-036868	Ficedula albicollis	90.31	0.00e+00	1198.00
IUUC-Gmo-038534	Gadus morhua	87.01	2.00e-75	275.00
IUUC-Gga-040560	Gallus gallus	89.08	0.00e+00	1304.00
IUUC-Gac-042540	Gasterosteus aculeatus	63.62	0.00e+00	752.00
IUUC-Ggo-045443	Gorilla gorilla	99.87	0.00e+00	1442.00
IUUC-Itr-048471	Ictidomys tridecemlineatus	98.38	0.00e+00	1434.00
IUUC-Lch-050620	Latimeria chalumnae	77.81	0.00e+00	973.00
IUUC-Loc-051793	Lepisosteus oculatus	74.84	0.00e+00	881.00
IUUC-Laf-053382	Loxodonta africana	96.77	0.00e+00	1422.00
IUUC-Mcc-055395	Macaca mulatta	99.46	0.00e+00	1435.00
IUUC-Meu-056456	Macropus eugenii	93.71	0.00e+00	1292.00
IUUC-Mga-059977	Meleagris gallopavo	88.72	0.00e+00	1314.00
IUUC-Mmr-061361	Microcebus murinus	99.06	0.00e+00	1444.00
IUUC-Mdo-062760	Monodelphis domestica	92.44	0.00e+00	1216.00
IUUC-Mmu-063230	Mus musculus	97.71	0.00e+00	1417.00
IUUC-Mpu-066367	Mustela putorius furo	98.65	0.00e+00	1404.00
IUUC-Mlu-067638	Myotis lucifugus	97.17	0.00e+00	1394.00
IUUC-Nle-069275	Nomascus leucogenys	99.67	0.00e+00	1188.00
IUUC-Opr-070230	Ochotona princeps	94.76	0.00e+00	875.00
IUUC-Ont-071373	Oreochromis niloticus	63.04	0.00e+00	760.00
IUUC-Ocu-073942	Oryctolagus cuniculus	97.85	0.00e+00	1421.00
IUUC-Oga-088490	Otolemur garnettii	98.91	0.00e+00	1432.00
IUUC-Oar-090130	Ovis aries	76.64	0.00e+00	1028.00
IUUC-Ptr-090567	Pan troglodytes	100.00	0.00e+00	1293.00
IUUC-Pan-092221	Papio anubis	99.46	0.00e+00	1441.00
IUUC-Psi-093694	Pelodiscus sinensis	89.35	5.00e-86	311.00
IUUC-Pfo-096692	Poecilia formosa	62.38	0.00e+00	757.00
IUUC-Pab-098500	Pongo abelii	99.33	0.00e+00	1436.00
IUUC-Pca-100185	Procavia capensis	97.84	0.00e+00	736.00
IUUC-Pva-102151	Pteropus vampyrus	98.63	0.00e+00	866.00
IUUC-Rno-105171	Rattus norvegicus	97.46	0.00e+00	1276.00
IUUC-Sha-106646	Sarcophilus harrisii	92.25	0.00e+00	1342.00
IUUC-Sar-113486	Sorex araneus	96.86	0.00e+00	1216.00
IUUC-Ssc-116214	Sus scrofa	98.66	0.00e+00	1269.00
IUUC-Tgu-117045	Taeniopygia guttata	90.28	0.00e+00	1345.00
IUUC-Tru-118699	Takifugu rubripes	61.20	0.00e+00	746.00
IUUC-Tsy-119393	Tarsius syrichta	96.36	0.00e+00	1385.00
IUUC-Tni-119917	Tetraodon nigroviridis	61.86	0.00e+00	730.00
IUUC-Vpa-130539	Vicugna pacos	98.34	0.00e+00	1149.00
IUUC-Xtr-132883	Xenopus tropicalis	81.29	0.00e+00	1167.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence