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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046767
UUCD1 version UUC-HoS-01074
Ensembl Protein ID ENSP00000401053.1
UniProt Accession Q96LR5; UB2E2_HUMAN
Genbank Protein ID BAB71605.1; AAH22332.1
Protein Name Ubiquitin-conjugating enzyme E2 E2; E2 ubiquitin-conjugating enzyme E2; UbcH8; Ubiquitin carrier protein E2; Ubiquitin-protein ligase E2
Genbank Nucleotide ID AK057886; BC022332
Gene Name UBE2E2; UBCH8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000182247.9 ENST00000425792.5 ENSP00000401053.1
ENSG00000182247.9 ENST00000452894.5 ENSP00000392800.1
ENSG00000182247.9 ENST00000335798.8 ENSP00000338340.4
ENSG00000182247.9 ENST00000628311.1 ENSP00000486775.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 20704751; 18597043
Classification
Family E-value Score Start End
E2/UBC 8.60e-50 169.8 59 194
Active Site
Position(s) Description Evidence
139 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
    R++kel+e++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f++dYPfkPPkv+f t+i+h+n++++G +Cl+ilk ++W
   Q: 59 RIQKELAEITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPKVTFRTRIYHCNINSQGVICLDILK--DNW 147
    9***********************.9************************************************************9..*** PP
   S: 93 spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
    spal++++vllsi+sll+++np++pl ++a+++ +nr+e+++++r+
   Q: 148 SPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQ 194
    ******************************************99985 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
Protein Sequence
(Fasta)
MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PEREQVQPKK KEGKISSKTA AKLSTSAKRI 60
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046767|E2,E2/UBC|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGAGGGAG GCGCGCGGCG CCGCATGGCC GACGTGGGGC TCGCGCTCTC GCGGTCTCTC 60
CCGGGCGGGC GCGCAGGCAC GCGCACTCGC GGGTGCGCGC GCGGACGGCC GGGCGGCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046767|E2,E2/UBC|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0032020--P:ISG15-protein conjugation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

KEGG hsa:7325
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-005044 Anolis carolinensis 98.01 1.00e-97 348.00
IUUC-Ame-011419 Astyanax mexicanus 95.80 2.00e-82 298.00
IUUC-Cre-022791 Chlamydomonas reinhardtii 80.13 1.00e-71 261.00
IUUC-Cho-024986 Choloepus hoffmanni 89.55 9.00e-87 312.00
IUUC-Dno-029130 Dasypus novemcinctus 100.00 1.00e-74 271.00
IUUC-Dme-032042 Drosophila melanogaster 87.65 2.00e-84 305.00
IUUC-Fca-035425 Felis catus 99.50 3.00e-85 307.00
IUUC-Fal-037043 Ficedula albicollis 98.51 2.00e-85 308.00
IUUC-Gmo-039645 Gadus morhua 91.13 8.00e-92 329.00
IUUC-Gga-040236 Gallus gallus 100.00 4.00e-85 306.00
IUUC-Gac-041661 Gasterosteus aculeatus 91.54 3.00e-91 327.00
IUUC-Loc-052673 Lepisosteus oculatus 94.53 2.00e-94 337.00
IUUC-Mcc-055072 Macaca mulatta 100.00 6.00e-86 309.00
IUUC-Mmr-060629 Microcebus murinus 100.00 6.00e-86 309.00
IUUC-Mmu-063733 Mus musculus 99.50 2.00e-99 354.00
IUUC-Mlu-067897 Myotis lucifugus 99.50 6.00e-86 309.00
IUUC-Nle-069421 Nomascus leucogenys 100.00 6.00e-86 309.00
IUUC-Ont-071325 Oreochromis niloticus 92.04 4.00e-92 330.00
IUUC-Oan-073704 Ornithorhynchus anatinus 100.00 1.00e-74 270.00
IUUC-Pab-098017 Pongo abelii 100.00 6.00e-86 309.00
IUUC-Pva-102561 Pteropus vampyrus 99.50 6.00e-86 309.00
IUUC-Tru-118527 Takifugu rubripes 95.77 1.00e-81 295.00
IUUC-Ttr-128358 Tursiops truncatus 100.00 6.00e-86 309.00
IUUC-Vpa-130232 Vicugna pacos 98.58 5.00e-81 293.00
Created Date 25-Jun-2017

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