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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046001
Ensembl Protein ID ENSP00000422907.1
UniProt Accession Q6P1K8; A6NED9; A8K8J6; B2RCU4; B7ZW39; T2H2L_HUMAN
Genbank Protein ID BAF85050.1; BAG37691.1; AAH64557.1; AAH65021.1; AAI05981.1; AAI71860.1
Protein Name General transcription factor IIH subunit 2-like protein; General transcription factor IIH polypeptide 2-like protein
Genbank Nucleotide ID AK292361; AK315282; AC147575; BC065021; BC105980; BC171860
Gene Name GTF2H2C; GTF2H2C_2; GTF2H2D
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000183474.15 ENST00000512736.5 ENSP00000427224.1
ENSG00000183474.15 ENST00000506129.5 ENSP00000427393.1
ENSG00000183474.15 ENST00000510979.5 ENSP00000422907.1
ENSG00000183474.15 ENST00000507595.1 ENSP00000427456.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 39.09 3.00e-71 263.00 IUUC-Sce-106434
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
 Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
Protein Sequence
(Fasta)
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH 60
LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046001|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGAGTTTCCG GCTGAGAGTC CTTCTAGCGG CGCCGGTGAG TCCGCGTGTG GAAGTCTGTG 60
AGGCGCAGAG GTGGGGCAGG CCGTCTGACT AGCTAGGCGG CTGGGAGCGT TTTCGTGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046001|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007198--Ssl1-like
IPR004595--TFIIH_C1-like_dom
IPR012170--TFIIH_SSL1/p44
IPR002035--VWF_A
IPR013087--Znf_C2H2_type
PROSITE

PS50234--VWFA
Pfam

PF07975--C1_4
PF04056--Ssl1
SMART

SM01047--C1_4
SM00327--VWA
Gene Ontology

GO:0000439--C:core TFIIH complex
GO:0005675--C:holo TFIIH complex
GO:0016607--C:nuclear speck
GO:0003676--F:nucleic acid binding
GO:0008270--F:zinc ion binding
GO:0006289--P:nucleotide-excision repair
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG hsa:728340; hsa:730394
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000536 Aegilops tauschii 35.46 6.00e-47 181.00
IUUC-Aml-002041 Ailuropoda melanoleuca 97.22 0.00e+00 755.00
IUUC-Atr-003056 Amborella trichopoda 44.31 5.00e-72 264.00
IUUC-Apl-003464 Anas platyrhynchos 88.06 0.00e+00 641.00
IUUC-Aca-004745 Anolis carolinensis 88.52 0.00e+00 654.00
IUUC-Aly-005559 Arabidopsis lyrata 41.73 8.00e-82 297.00
IUUC-Ath-007556 Arabidopsis thaliana 41.73 1.00e-81 297.00
IUUC-Ago-007851 Ashbya gossypii 38.58 1.00e-77 284.00
IUUC-Acl-008100 Aspergillus clavatus 39.37 2.00e-77 283.00
IUUC-Afl-008649 Aspergillus flavus 40.91 8.00e-12 61.20
IUUC-Afu-009066 Aspergillus fumigatus 38.65 1.00e-78 286.00
IUUC-Ani-009372 Aspergillus nidulans 38.94 1.00e-75 276.00
IUUC-Ang-009726 Aspergillus niger 38.65 2.00e-80 293.00
IUUC-Aor-010135 Aspergillus oryzae 38.33 1.00e-75 277.00
IUUC-Ate-010399 Aspergillus terreus 37.66 2.00e-24 105.00
IUUC-Ame-011618 Astyanax mexicanus 81.70 0.00e+00 665.00
IUUC-Bgr-012154 Blumeria graminis 36.08 4.00e-75 275.00
IUUC-Bta-012353 Bos taurus 96.71 0.00e+00 755.00
IUUC-Bci-013932 Botrytis cinerea 38.35 1.00e-79 290.00
IUUC-Bdi-014391 Brachypodium distachyon 40.51 2.00e-77 282.00
IUUC-Bol-015128 Brassica oleracea 41.92 2.00e-82 299.00
IUUC-Bra-017932 Brassica rapa 41.90 2.00e-82 299.00
IUUC-Cel-018649 Caenorhabditis elegans 43.19 1.00e-83 303.00
IUUC-Cja-018776 Callithrix jacchus 98.48 0.00e+00 763.00
IUUC-Cfa-020584 Canis familiaris 97.97 0.00e+00 759.00
IUUC-Cpo-021300 Cavia porcellus 96.46 0.00e+00 754.00
IUUC-Cre-022657 Chlamydomonas reinhardtii 41.95 6.00e-74 271.00
IUUC-Csa-024092 Chlorocebus sabaeus 99.24 0.00e+00 769.00
IUUC-Cho-024919 Choloepus hoffmanni 90.00 4.00e-105 373.00
IUUC-Cin-025386 Ciona intestinalis 54.29 8.00e-109 387.00
IUUC-Csv-026295 Ciona savignyi 50.12 7.00e-107 380.00
IUUC-Cgl-026612 Colletotrichum gloeosporioides 35.15 1.00e-68 253.00
IUUC-Cne-026956 Cryptococcus neoformans 35.12 2.00e-79 289.00
IUUC-Cme-027150 Cyanidioschyzon merolae 32.15 6.00e-46 178.00
IUUC-Dre-027962 Danio rerio 82.17 0.00e+00 674.00
IUUC-Dno-029979 Dasypus novemcinctus 95.80 0.00e+00 643.00
IUUC-Dse-031405 Dothistroma septosporum 35.68 2.00e-65 243.00
IUUC-Dme-031710 Drosophila melanogaster 50.49 4.00e-109 388.00
IUUC-Ete-032631 Echinops telfairi 89.37 0.00e+00 692.00
IUUC-Eca-034054 Equus caballus 94.68 0.00e+00 731.00
IUUC-Fca-035724 Felis catus 92.41 0.00e+00 709.00
IUUC-Fal-036987 Ficedula albicollis 89.03 0.00e+00 728.00
IUUC-Fox-037692 Fusarium oxysporum 36.17 1.00e-69 257.00
IUUC-Fso-038442 Fusarium solani 37.80 2.00e-70 259.00
IUUC-Gmo-039273 Gadus morhua 77.18 0.00e+00 642.00
IUUC-Ggr-040009 Gaeumannomyces graminis 33.96 8.00e-55 208.00
IUUC-Gga-041089 Gallus gallus 87.85 0.00e+00 724.00
IUUC-Gac-041978 Gasterosteus aculeatus 77.30 5.00e-176 610.00
IUUC-Gma-043371 Glycine max 41.73 2.00e-85 309.00
IUUC-Itr-048355 Ictidomys tridecemlineatus 97.22 0.00e+00 783.00
IUUC-Kpa-049235 Komagataella pastoris 40.35 4.00e-73 268.00
IUUC-Lch-049926 Latimeria chalumnae 84.56 0.00e+00 686.00
IUUC-Lpe-051352 Leersia perrieri 40.25 3.00e-74 272.00
IUUC-Loc-051987 Lepisosteus oculatus 84.24 0.00e+00 683.00
IUUC-Lma-053171 Leptosphaeria maculans 33.70 1.00e-58 221.00
IUUC-Laf-054372 Loxodonta africana 97.71 0.00e+00 760.00
IUUC-Mcc-055108 Macaca mulatta 99.49 0.00e+00 771.00
IUUC-Mor-056990 Magnaporthe oryzae 34.54 3.00e-69 256.00
IUUC-Mtr-058401 Medicago truncatula 41.21 4.00e-84 305.00
IUUC-Mla-059186 Melampsora laricipopulina 39.56 2.00e-82 299.00
IUUC-Mvi-060262 Microbotryum violaceum 37.87 7.00e-81 294.00
IUUC-Mmr-061688 Microcebus murinus 88.89 0.00e+00 691.00
IUUC-Mdo-062154 Monodelphis domestica 93.92 0.00e+00 761.00
IUUC-Mmu-064232 Mus musculus 96.96 0.00e+00 748.00
IUUC-Mac-065091 Musa acuminata 42.33 3.00e-81 295.00
IUUC-Mpu-066747 Mustela putorius furo 90.63 0.00e+00 686.00
IUUC-Mlu-067799 Myotis lucifugus 88.38 0.00e+00 669.00
IUUC-Nfi-068371 Neosartorya fischeri 32.69 6.00e-18 83.20
IUUC-Ncr-068704 Neurospora crassa 37.21 6.00e-69 254.00
IUUC-Nle-069054 Nomascus leucogenys 98.48 0.00e+00 759.00
IUUC-Ont-071624 Oreochromis niloticus 78.06 0.00e+00 627.00
IUUC-Oan-072898 Ornithorhynchus anatinus 92.15 0.00e+00 742.00
IUUC-Ocu-074289 Oryctolagus cuniculus 98.39 6.00e-177 613.00
IUUC-Oba-075985 Oryza barthii 39.75 3.00e-73 269.00
IUUC-Obr-076887 Oryza brachyantha 40.61 6.00e-77 281.00
IUUC-Ogl-077823 Oryza glaberrima 39.75 3.00e-73 269.00
IUUC-Ogu-078412 Oryza glumaepatula 41.44 5.00e-67 248.00
IUUC-Oin-079569 Oryza indica 36.94 2.00e-49 190.00
IUUC-Olo-080249 Oryza longistaminata 37.09 2.00e-48 187.00
IUUC-Ome-081240 Oryza meridionalis 41.44 8.00e-67 248.00
IUUC-Oni-082152 Oryza nivara 41.44 7.00e-67 248.00
IUUC-Opu-084011 Oryza punctata 39.49 5.00e-73 268.00
IUUC-Oru-084719 Oryza rufipogon 41.08 2.00e-68 253.00
IUUC-Osa-085286 Oryza sativa 40.00 1.00e-74 273.00
IUUC-Ola-086525 Oryzias latipes 68.19 8.00e-149 520.00
IUUC-Olu-087876 Ostreococcus lucimarinus 41.49 2.00e-65 243.00
IUUC-Oga-088125 Otolemur garnettii 95.19 0.00e+00 747.00
IUUC-Oar-089701 Ovis aries 97.22 0.00e+00 759.00
IUUC-Ptr-091218 Pan troglodytes 99.24 0.00e+00 770.00
IUUC-Pan-091755 Papio anubis 99.49 0.00e+00 771.00
IUUC-Psi-094061 Pelodiscus sinensis 92.91 0.00e+00 753.00
IUUC-Pma-094430 Petromyzon marinus 75.89 5.00e-114 403.00
IUUC-Pno-094900 Phaeosphaeria nodorum 31.11 2.00e-22 100.00
IUUC-Ppa-095895 Physcomitrella patens 42.30 2.00e-82 299.00
IUUC-Pfo-096297 Poecilia formosa 81.03 5.00e-120 423.00
IUUC-Pab-097717 Pongo abelii 99.49 0.00e+00 771.00
IUUC-Pop-098938 Populus trichocarpa 42.38 2.00e-84 305.00
IUUC-Pca-100389 Procavia capensis 86.29 6.00e-167 580.00
IUUC-Ppe-102045 Prunus persica 41.79 1.00e-81 296.00
IUUC-Pva-102357 Pteropus vampyrus 94.71 2.00e-103 368.00
IUUC-Pgr-103399 Puccinia graminis 41.91 8.00e-89 320.00
IUUC-Ptt-103872 Puccinia triticina 42.16 6.00e-89 321.00
IUUC-Pte-104092 Pyrenophora teres 33.51 6.00e-51 195.00
IUUC-Pyt-104669 Pyrenophora triticirepentis 33.78 2.00e-51 196.00
IUUC-Rno-105515 Rattus norvegicus 96.21 0.00e+00 746.00
IUUC-Sce-106434 Saccharomyces cerevisiae 39.09 1.00e-78 287.00
IUUC-Sha-106808 Sarcophilus harrisii 94.68 0.00e+00 763.00
IUUC-Sja-107995 Schizosaccharomyces japonicus 40.82 1.00e-76 280.00
IUUC-Spo-108044 Schizosaccharomyces pombe 39.29 5.00e-79 288.00
IUUC-Smo-109581 Selaginella moellendorffii 42.32 5.00e-84 304.00
IUUC-Sit-110704 Setaria italica 40.46 1.00e-77 283.00
IUUC-Sly-110990 Solanum lycopersicum 45.13 3.00e-67 248.00
IUUC-Stu-112542 Solanum tuberosum 42.47 9.00e-46 176.00
IUUC-Sar-113766 Sorex araneus 95.67 4.00e-177 613.00
IUUC-Sbi-114016 Sorghum bicolor 40.71 1.00e-75 276.00
IUUC-Sre-115099 Sporisorium reilianum 38.41 4.00e-78 285.00
IUUC-Ssc-115277 Sus scrofa 97.47 0.00e+00 744.00
IUUC-Tgu-117343 Taeniopygia guttata 88.07 0.00e+00 723.00
IUUC-Tru-118397 Takifugu rubripes 76.28 4.00e-174 603.00
IUUC-Tni-120272 Tetraodon nigroviridis 75.38 1.00e-171 595.00
IUUC-Tca-121514 Theobroma cacao 42.89 2.00e-87 315.00
IUUC-Tre-121990 Trichoderma reesei 37.47 2.00e-68 253.00
IUUC-Tvi-122504 Trichoderma virens 38.63 5.00e-68 251.00
IUUC-Tae-123153 Triticum aestivum 40.10 1.00e-76 280.00
IUUC-Tur-126693 Triticum urartu 42.91 1.00e-58 219.00
IUUC-Tme-127011 Tuber melanosporum 38.44 2.00e-75 276.00
IUUC-Tbe-127939 Tupaia belangeri 97.97 0.00e+00 762.00
IUUC-Ttr-128889 Tursiops truncatus 88.61 0.00e+00 698.00
IUUC-Uma-129450 Ustilago maydis 37.65 1.00e-78 287.00
IUUC-Vda-129919 Verticillium dahliae 37.14 2.00e-65 243.00
IUUC-Vpa-130419 Vicugna pacos 32.14 9.20e-02 31.60
IUUC-Vvi-130928 Vitis vinifera 43.91 8.00e-87 314.00
IUUC-Xtr-131891 Xenopus tropicalis 73.37 3.00e-176 610.00
IUUC-Xma-133260 Xiphophorus maculatus 80.24 1.00e-118 419.00
IUUC-Yli-134578 Yarrowia lipolytica 37.78 2.00e-74 273.00
IUUC-Zma-135427 Zea mays 40.82 1.00e-76 280.00
Created Date 25-Jun-2017

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