iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013524

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-conjugating enzyme UBE2F; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F

Genbank Nucleotide ID

BC114675

Gene Name

UBE2F

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000026114.2	ENSBTAT00000037020.2	ENSBTAP00000036864.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.60e-37	126.7	37	177

Active Site

Position(s)	Description	Evidence
116	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk... 87
           l ke++ele++ p ++++++ d ++l+ ++++++ p++ +Y+gg+F++e e+p+ Y++ PPkvk+lt+i+hPn++e+G++Cls+l+   
   Q: 37   LVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTRIWHPNITETGEICLSLLRehs 124
           679********************99*********.**************************************************7778 PP
   S: 88   .eeekWspalsvesvllsiqsllae.pnpesplneeaaellkknreeykkkvr 138
            + + W p+ ++++v+++++sl+++  n+++pln eaae++ +++e++++kv+
   Q: 125  iDGTGWAPTRTLKDVVWGLNSLFTDlLNFDDPLNIEAAEHHLRDKEDFRNKVE 177
           8899*******************8879***********************996 PP

Organism

Bos taurus

Functional Description
(View)

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

Protein Sequence
(Fasta)

MLTLASKLKR DDGLKGSRAS ATASDSTRRV SVRDRLLVKE VAELEANLPC TCKVHFPDPN 60
KLHCFQLTVT PDEGYYQGGK FQFETEVPDA YNMVPPKVKC LTRIWHPNIT ETGEICLSLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGTCTCGC TGCCGCAGGC CGGCTGGGGC ATGGTGTTGG GCGCCGGGCC CGCCTCGCCT 60
GTCTCGGGGT GCCCAGGTGA GTAGAGCGCG GCCCTGCGGC GGGCTGCAGG GGGCCGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0019788--F:NEDD8 transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0045116--P:protein neddylation

KEGG

bta:617083

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001473	Ailuropoda melanoleuca	98.92	2.00e-94	337.00
IUUC-Apl-003569	Anas platyrhynchos	86.73	1.00e-48	184.00
IUUC-Aca-005152	Anolis carolinensis	90.27	6.00e-98	349.00
IUUC-Ame-011839	Astyanax mexicanus	81.08	4.00e-90	323.00
IUUC-Cel-018579	Caenorhabditis elegans	57.03	2.00e-35	141.00
IUUC-Cja-019211	Callithrix jacchus	96.76	3.00e-96	343.00
IUUC-Cfa-020014	Canis familiaris	98.92	2.00e-94	337.00
IUUC-Cpo-022479	Cavia porcellus	96.76	3.00e-96	343.00
IUUC-Cho-024583	Choloepus hoffmanni	66.49	3.00e-62	230.00
IUUC-Cin-025378	Ciona intestinalis	50.00	4.00e-53	200.00
IUUC-Csv-026195	Ciona savignyi	51.91	5.00e-51	193.00
IUUC-Dre-028671	Danio rerio	82.70	2.00e-91	327.00
IUUC-Dno-029004	Dasypus novemcinctus	98.38	4.00e-108	383.00
IUUC-Dor-030940	Dipodomys ordii	95.14	3.00e-95	340.00
IUUC-Eca-034345	Equus caballus	99.46	8.00e-95	338.00
IUUC-Fca-036125	Felis catus	98.92	2.00e-94	337.00
IUUC-Fal-036808	Ficedula albicollis	94.05	6.00e-103	365.00
IUUC-Gmo-039394	Gadus morhua	91.15	2.00e-61	226.00
IUUC-Gga-041269	Gallus gallus	89.78	6.00e-96	342.00
IUUC-Gac-041480	Gasterosteus aculeatus	84.32	5.00e-91	326.00
IUUC-Ggo-045010	Gorilla gorilla	97.30	2.00e-107	380.00
IUUC-Hsa-046664	Homo sapiens	97.30	2.00e-107	380.00
IUUC-Itr-048522	Ictidomys tridecemlineatus	96.76	1.00e-95	341.00
IUUC-Loc-052137	Lepisosteus oculatus	85.41	2.00e-93	334.00
IUUC-Laf-053694	Loxodonta africana	96.76	9.00e-98	348.00
IUUC-Mcc-055638	Macaca mulatta	97.30	2.00e-107	380.00
IUUC-Meu-056568	Macropus eugenii	78.92	8.00e-82	295.00
IUUC-Mga-059437	Meleagris gallopavo	95.14	2.00e-103	367.00
IUUC-Mmr-060651	Microcebus murinus	94.44	2.00e-90	325.00
IUUC-Mdo-061993	Monodelphis domestica	94.59	2.00e-102	365.00
IUUC-Mmu-064372	Mus musculus	95.14	6.00e-95	339.00
IUUC-Mpu-066423	Mustela putorius furo	98.38	4.00e-94	336.00
IUUC-Mlu-067910	Myotis lucifugus	98.38	4.00e-94	336.00
IUUC-Nle-069032	Nomascus leucogenys	96.76	3.00e-96	343.00
IUUC-Opr-070798	Ochotona princeps	95.68	1.00e-105	374.00
IUUC-Ont-071232	Oreochromis niloticus	84.86	9.00e-92	328.00
IUUC-Oan-072779	Ornithorhynchus anatinus	94.21	8.00e-67	244.00
IUUC-Ocu-074366	Oryctolagus cuniculus	92.43	5.00e-103	366.00
IUUC-Ola-087548	Oryzias latipes	88.98	2.00e-62	229.00
IUUC-Oga-089149	Otolemur garnettii	97.84	2.00e-98	350.00
IUUC-Oar-089662	Ovis aries	100.00	8.00e-95	338.00
IUUC-Ptr-090895	Pan troglodytes	97.30	2.00e-107	380.00
IUUC-Pan-092771	Papio anubis	96.77	6.00e-106	375.00
IUUC-Psi-093582	Pelodiscus sinensis	94.05	1.00e-102	365.00
IUUC-Pma-094321	Petromyzon marinus	85.71	9.00e-68	248.00
IUUC-Pfo-096040	Poecilia formosa	85.95	5.00e-93	332.00
IUUC-Pab-097931	Pongo abelii	97.30	2.00e-107	380.00
IUUC-Pca-100697	Procavia capensis	97.93	5.00e-85	305.00
IUUC-Pva-102609	Pteropus vampyrus	97.30	7.00e-95	338.00
IUUC-Rno-105622	Rattus norvegicus	95.68	6.00e-95	339.00
IUUC-Sha-107614	Sarcophilus harrisii	93.55	2.00e-101	360.00
IUUC-Ssc-115597	Sus scrofa	97.84	4.00e-97	346.00
IUUC-Tgu-117397	Taeniopygia guttata	94.59	1.00e-103	367.00
IUUC-Tru-118496	Takifugu rubripes	82.70	3.00e-89	320.00
IUUC-Tsy-119592	Tarsius syrichta	98.38	1.00e-98	351.00
IUUC-Tni-119759	Tetraodon nigroviridis	83.24	6.00e-90	322.00
IUUC-Tbe-128085	Tupaia belangeri	80.74	3.00e-61	226.00
IUUC-Ttr-129228	Tursiops truncatus	98.92	7.00e-94	335.00
IUUC-Xtr-131773	Xenopus tropicalis	91.97	2.00e-62	230.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence