iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Cel-018579

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-conjugating enzyme ubc-12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 12

Genbank Nucleotide ID

Z81108

Gene Name

ubc-12; R09B3.4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00006707	R09B3.4	R09B3.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.10e-32	111.5	31	174

Active Site

Position(s)	Description	Evidence
112	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 4    kelkel....ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk....eeekWspals 97
           +el++l    ++++++  ++++ + s l+e+e++++ p++ +Y+gg+F+++i++p++Y+  PP vk+ltk++hPn++e+G++Clsil+    ++  W+p+ +
   Q: 31   QELQQLetalRDQKQKLWHLEVPSTSCLHELELTVT-PQEGIYRGGKFRFKITVPPEYNNVPPVVKCLTKVWHPNINEDGSICLSILRqnslDQYGWRPTRN 131
           555555111144455666777777777*********.**************************************************87888999******* PP
   S: 98   vesvllsiqsllae.pnpesplneeaaellkknreeykkkvre 139
           +++v+ +++sl+++   ++++ln +aa+++++nre+++++vre
   Q: 132  LTDVVHGLVSLFNDlMDFNDALNIQAAQMWSQNRESFNHRVRE 174
           ************99789***********************985 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MFNLQKRING NNEDGRYLET RIAVRDKLLA QELQQLETAL RDQKQKLWHL EVPSTSCLHE 60
LELTVTPQEG IYRGGKFRFK ITVPPEYNNV PPVVKCLTKV WHPNINEDGS ICLSILRQNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAATGTTCA ATCTTCAAAA ACGAATCAAC GGCAACAACG AGGACGGTCG GTATCTTGAA 60
ACCCGCATCG CCGTCCGTGA CAAGCTCCTA GCTCAGGGTA TGTGGCTGCT TTATAAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0016874--F:ligase activity
GO:0019788--F:NEDD8 transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0007275--P:multicellular organism development
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045116--P:protein neddylation

KEGG

cel:CELE_R09B3.4

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001473	Ailuropoda melanoleuca	56.15	1.00e-41	161.00
IUUC-Apl-003569	Anas platyrhynchos	58.24	3.00e-28	115.00
IUUC-Aca-005152	Anolis carolinensis	51.88	3.00e-44	169.00
IUUC-Ath-006846	Arabidopsis thaliana	39.66	2.00e-20	90.50
IUUC-Ago-007910	Ashbya gossypii	37.68	4.00e-20	89.70
IUUC-Ang-009728	Aspergillus niger	39.52	3.00e-22	95.90
IUUC-Ame-011839	Astyanax mexicanus	45.98	1.00e-42	164.00
IUUC-Bta-013524	Bos taurus	56.15	1.00e-41	161.00
IUUC-Bdi-014079	Brachypodium distachyon	33.91	3.00e-23	99.80
IUUC-Bol-015929	Brassica oleracea	40.52	2.00e-20	90.90
IUUC-Bra-016702	Brassica rapa	38.28	6.00e-21	92.40
IUUC-Cja-019211	Callithrix jacchus	52.94	4.00e-43	166.00
IUUC-Cfa-020014	Canis familiaris	56.15	1.00e-41	161.00
IUUC-Cpo-022479	Cavia porcellus	52.94	4.00e-43	166.00
IUUC-Cre-022865	Chlamydomonas reinhardtii	39.72	3.00e-24	103.00
IUUC-Cho-024583	Choloepus hoffmanni	41.28	1.00e-20	90.90
IUUC-Cin-025378	Ciona intestinalis	38.17	1.00e-36	144.00
IUUC-Csv-026195	Ciona savignyi	44.24	2.00e-37	146.00
IUUC-Cme-027287	Cyanidioschyzon merolae	45.57	3.00e-16	77.00
IUUC-Dre-028671	Danio rerio	48.12	2.00e-42	164.00
IUUC-Dno-029004	Dasypus novemcinctus	52.83	6.00e-46	175.00
IUUC-Dor-030940	Dipodomys ordii	52.94	6.00e-43	165.00
IUUC-Eca-034345	Equus caballus	56.15	1.00e-41	161.00
IUUC-Fca-036125	Felis catus	56.15	1.00e-41	161.00
IUUC-Fal-036808	Ficedula albicollis	51.88	2.00e-45	173.00
IUUC-Fox-037877	Fusarium oxysporum	38.21	1.00e-20	91.30
IUUC-Fso-038428	Fusarium solani	39.02	3.00e-21	93.20
IUUC-Gmo-039394	Gadus morhua	56.25	7.00e-36	140.00
IUUC-Gga-041269	Gallus gallus	51.25	2.00e-43	167.00
IUUC-Gac-041480	Gasterosteus aculeatus	48.12	9.00e-44	167.00
IUUC-Gma-043805	Glycine max	38.33	8.00e-21	92.00
IUUC-Ggo-045010	Gorilla gorilla	53.46	4.00e-46	176.00
IUUC-Hsa-046664	Homo sapiens	53.46	4.00e-46	176.00
IUUC-Itr-048522	Ictidomys tridecemlineatus	51.63	6.00e-42	162.00
IUUC-Lpe-050743	Leersia perrieri	40.83	3.00e-21	93.20
IUUC-Loc-052137	Lepisosteus oculatus	51.25	5.00e-44	168.00
IUUC-Laf-053694	Loxodonta africana	53.85	6.00e-45	172.00
IUUC-Mcc-055638	Macaca mulatta	53.46	4.00e-46	176.00
IUUC-Meu-056568	Macropus eugenii	46.88	1.00e-37	147.00
IUUC-Mga-059437	Meleagris gallopavo	52.50	7.00e-46	175.00
IUUC-Mmr-060651	Microcebus murinus	51.95	1.00e-40	158.00
IUUC-Mdo-061993	Monodelphis domestica	53.46	7.00e-46	175.00
IUUC-Mmu-064372	Mus musculus	52.94	5.00e-43	165.00
IUUC-Mac-064435	Musa acuminata	40.83	7.00e-23	98.60
IUUC-Mpu-066423	Mustela putorius furo	55.38	2.00e-41	160.00
IUUC-Mlu-067910	Myotis lucifugus	54.62	6.00e-41	158.00
IUUC-Ncr-068944	Neurospora crassa	38.58	4.00e-22	96.30
IUUC-Nle-069032	Nomascus leucogenys	52.94	4.00e-43	166.00
IUUC-Opr-070798	Ochotona princeps	53.46	4.00e-46	175.00
IUUC-Ont-071232	Oreochromis niloticus	48.12	6.00e-44	168.00
IUUC-Oan-072779	Ornithorhynchus anatinus	56.41	2.00e-37	146.00
IUUC-Ocu-074366	Oryctolagus cuniculus	51.57	2.00e-44	169.00
IUUC-Oba-075203	Oryza barthii	42.50	1.00e-22	97.40
IUUC-Obr-076431	Oryza brachyantha	43.33	1.00e-23	101.00
IUUC-Ogl-077404	Oryza glaberrima	43.33	2.00e-23	100.00
IUUC-Ogu-078347	Oryza glumaepatula	42.50	1.00e-22	97.40
IUUC-Oin-080060	Oryza indica	43.33	2.00e-23	101.00
IUUC-Olo-080602	Oryza longistaminata	43.33	3.00e-23	101.00
IUUC-Ome-081870	Oryza meridionalis	43.33	2.00e-23	101.00
IUUC-Oni-082192	Oryza nivara	43.33	2.00e-23	100.00
IUUC-Opu-083937	Oryza punctata	42.50	9.00e-23	98.20
IUUC-Oru-084750	Oryza rufipogon	43.33	2.00e-23	100.00
IUUC-Osa-085857	Oryza sativa	43.33	2.00e-23	100.00
IUUC-Ola-087548	Oryzias latipes	54.70	9.00e-37	143.00
IUUC-Oga-089149	Otolemur garnettii	53.85	8.00e-45	171.00
IUUC-Oar-089662	Ovis aries	56.15	1.00e-41	161.00
IUUC-Ptr-090895	Pan troglodytes	53.46	4.00e-46	176.00
IUUC-Pan-092771	Papio anubis	53.12	9.00e-45	171.00
IUUC-Psi-093582	Pelodiscus sinensis	51.25	2.00e-45	173.00
IUUC-Pma-094321	Petromyzon marinus	61.68	4.00e-37	145.00
IUUC-Pno-094972	Phaeosphaeria nodorum	37.12	9.00e-22	95.10
IUUC-Pfo-096040	Poecilia formosa	48.12	6.00e-44	168.00
IUUC-Pab-097931	Pongo abelii	53.46	4.00e-46	176.00
IUUC-Pca-100697	Procavia capensis	56.15	2.00e-41	160.00
IUUC-Pva-102609	Pteropus vampyrus	51.32	2.00e-41	160.00
IUUC-Pyt-104616	Pyrenophora triticirepentis	39.20	2.00e-22	96.70
IUUC-Rno-105622	Rattus norvegicus	52.94	5.00e-43	165.00
IUUC-Sha-107614	Sarcophilus harrisii	52.80	1.00e-44	171.00
IUUC-Spo-108143	Schizosaccharomyces pombe	40.91	3.00e-22	96.30
IUUC-Sbi-114410	Sorghum bicolor	43.33	1.00e-23	100.00
IUUC-Ssc-115597	Sus scrofa	55.38	3.00e-41	159.00
IUUC-Tgu-117397	Taeniopygia guttata	51.88	1.00e-45	174.00
IUUC-Tru-118496	Takifugu rubripes	49.38	4.00e-44	169.00
IUUC-Tsy-119592	Tarsius syrichta	53.21	2.00e-44	170.00
IUUC-Tni-119759	Tetraodon nigroviridis	48.75	7.00e-44	168.00
IUUC-Tca-121640	Theobroma cacao	38.52	4.00e-21	92.80
IUUC-Tre-122115	Trichoderma reesei	37.01	3.00e-20	90.10
IUUC-Tbe-128085	Tupaia belangeri	41.98	9.00e-26	107.00
IUUC-Ttr-129228	Tursiops truncatus	56.69	3.00e-41	159.00
IUUC-Vvi-131182	Vitis vinifera	35.95	1.00e-21	95.10
IUUC-Xtr-131773	Xenopus tropicalis	50.48	1.00e-26	110.00
IUUC-Xma-133013	Xiphophorus maculatus	48.12	7.00e-44	168.00
IUUC-Yli-134467	Yarrowia lipolytica	41.78	3.00e-24	103.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence